Bone Fragility Causes & Reasons

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Bone Fragility Symptom Checker: Possible causes include Osteoporosis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Osteoporosis

Fractures associated with bone fragility are frequent, particularly in elderly women. [english.prescrire.org]

In conclusion, hemizygous mutations in PLS3 are associated with osteoporosis and bone fragility in childhood, but in contrast to bone fragility caused by mutations in collagen [ncbi.nlm.nih.gov]

The prevention of fractures associated with bone fragility is based on fall prevention and regular physical activity, and drug therapy only in some cases. [english.prescrire.org]

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Duchenne Muscular Dystrophy

Although cortisone therapy in Duchenne muscular dystrophy does not seem to increase bone fragility or the general risk of fractures, it does increase the risk of vertebral [socialstyrelsen.se]

However, these medicines have side effects such as weight gain, facial changes, loss of linear (height) growth, and bone fragility that can be especially troubling in children [web.archive.org]

Long‐bone fractures were documented in 25% of boys in both groups, with no difference between groups. [doi.org]

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Cleidocranial Dysplasia

[…] mineral density Increased bone density 0011001 Increased susceptibility to fractures Abnormal susceptibility to fractures Bone fragility Frequent broken bones Increased bone [rarediseases.info.nih.gov]

fragility, nanism and partial agenesis of hand and foot phalanges ( 5, 6 ). [scielo.br]

fragility, nanism and partial agenesis of hand and foot phalanges (5,6). [rb.org.br]

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Osteogenesis Imperfecta

Until recently, only one report of a boy with an Sp7/Osx pathogenic variant presenting with bone fragility, limb deformities and normal hearing has been described in the literature [ncbi.nlm.nih.gov]

These findings provide proof-of-concept that NBAS mutations have mechanistic effects in bone, and that NBAS variants are a novel cause of bone fragility, which is distinguishable [ncbi.nlm.nih.gov]

KEYWORDS: Atypical fracture; Blue sclerae; Bone fragility; Collagen; Zebra sign [ncbi.nlm.nih.gov]

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Bruck Syndrome

Bruck syndrome is an autosomal recessive syndrome consisting of bone fragility and congenital joint contractures. [ncbi.nlm.nih.gov]

Case report 124 Downloads 6 Citations Keywords Osteogenesis Imperfecta Bone Fragility Joint Contracture Normal Vaginal Delivery Osteogenesis Imperfecta Type These keywords [link.springer.com]

fragility. [jim.bmj.com]

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McCune-Albright Syndrome

Because these patients have increased bone fragility, particular attention must be paid to careful positioning and padding [22]. [journals.lww.com]

Cole DE et al. (1983) Panostotic fibrous dysplasia: a congenital disorder of bone with unusual facial appearance, bone fragility, hyperphosphatasemia, and hypophosphatemia [moldiag.com]

Vascular fragility may make venous access difficult [22]. [journals.lww.com]

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X-Linked Osteoporosis with Fractures

Osteoporosis is a prevalent disorder characterized by low bone mass and microarchitectural deterioration of bone tissue, which results in bone fragility and fractures. 1 It [nejm.org]

The hallmark feature of osteogenesis imperfecta is osteoporosis and fragile bones that fracture easily, as well as, blue sclera, dental fragility, and hearing loss. [radiopaedia.org]

Put simply, it’s a condition that weakens your bones, making them fragile and more likely to break. [dailymail.co.uk]

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Cole-Carpenter Syndrome

Definition A form of Cole-Carpenter syndrome, a disorder characterized by features of osteogenesis imperfecta such as bone deformities and severe bone fragility with frequent [uniprot.org]

Cole-Carpenter syndrome-1 (CLCRP1) is an independent osteogenesis imperfect (OI)-like disorder that manifests as bone fragility, craniosynostosis, ocular proptosis, hydrocephalus [ncbi.nlm.nih.gov]

Orpha Number: 2050 Definition An extremely rare form of bone dysplasia characterized by the features of osteogenesis imperfecta such as bone fragility associated with multiple [malacards.org]

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Osteogenesis Imperfecta Type 2

Osteogenesis imperfecta type 2: An inherited connective tissue disorder with extremely severe bone fragility. This is the lethal form of "brittle bone disease." [medicinenet.com]

Disease definition Osteogenesis imperfecta type II is a lethal type of osteogenesis imperfecta (OI; see this term), a genetic disorder characterized by increased bone fragility [orpha.net]

low bone mass and susceptibility to bone fractures. [orpha.net]

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Osteogenesis Imperfecta Type 3

Abstract BackgroundOsteogenesis imperfecta (OI) is a heritable bone fragility disorder usually caused by dominant variants in COL1A1 or COL1A2 genes. [ncbi.nlm.nih.gov]

Disease definition Osteogenesis imperfecta type III is a severe type of osteogenesis imperfecta (OI; see this term), a genetic disorder characterized by increased bone fragility [orpha.net]

low bone mass and susceptibility to bone fractures. [orpha.net]

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Osteogenesis Imperfecta Type 13

OMIM : 57 Osteogenesis imperfecta (OI) is a connective tissue disorder characterized by bone fragility and low bone mass. [malacards.org]

Bone fragility with multiple fractures in the absence of an apparent trauma is the hallmark of OI. [kenkyugroup.org]

Osteogenesis imperfecta type 7 Osteogenesis imperfecta is a connective tissue disorder characterized by bone fragility and low bone mass. [ncbi.nlm.nih.gov]

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Osteogenesis Imperfecta Type 5

OMIM : 58 Osteogenesis imperfecta is a connective tissue disorder characterized by bone fragility and low bone mass. [malacards.org]

[…] type 5 Disease definition Osteogenesis imperfecta type V is a moderate type of osteogenesis imperfecta (OI; see this term), a genetic disorder characterized by increased bone [orpha.net]

Background: Osteogenesis imperfecta (OI) is a heterogeneous group of disorders characterized by bone fragility. [bone-abstracts.org]

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Osteogenesis Imperfecta Type 15

OMIM : 57 Osteogenesis imperfecta (OI) is a connective tissue disorder characterized by bone fragility and low bone mass. [malacards.org]

[…] forms of OI, hypophosphatasia, and other bone fragility phenotypes that overlap with OI. [uwcpdx.org]

It is a lethal form with collagen abnormalities resulting in dwarfism, bone fragility, low bone mass, high risk of fractures (rib and long bone), and deformity with in utero [iofbonehealth.org]

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Osteogenesis Imperfecta Type 16

[…] forms of OI, hypophosphatasia, and other bone fragility phenotypes that overlap with OI. [uwcpdx.org]

bone fragility and susceptibility to fractures after minimal trauma. [malacards.org]

Brittle Bone disease, also known as Osteogenesis Imperfecta (OI), is characterised by fragile bones that break easily. [specialeducationalneeds.co.uk]

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Calvarial Doughnut Lesions - Bone Fragility Syndrome

To report examples of disorders characterized by bone fragility, calvarial and/or gnathic fibro-osseous lesions, and metadiaphyseal undermodeling of the tubular bones. [link.springer.com]

CONCLUSION: These patients may represent a group of fragile bone syndromes which differ from osteogenesis imperfecta. [ncbi.nlm.nih.gov]

bone fragility and long bone bowing. [docslide.net]

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Pyle's Disease

Cortical-bone fragility is a common feature in osteoporosis that is linked to nonvertebral fractures. Regulation of cortical-bone homeostasis has proved elusive. [ncbi.nlm.nih.gov]

Summary of "Cortical- Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease." [bioportfolio.com]

Although trabecular bone is expanded, the dense outermost layer of bone (cortical bone) is thinner than normal. As a result, the bones are fragile and fracture easily. [ghr.nlm.nih.gov]

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Pyknodysostosis

Bone fragility and a history of frequent fractures may suggest the possibility of diagnosing osteogenesis imperfecta, although the fractures are much more severe with other [dx.doi.org]

Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised [ncbi.nlm.nih.gov]

View Article PubMed Google Scholar Chavassieux P, Seeman E, Delmas PD: Insights into material and structural basis of bone fragility from diseases associated with fractures [dx.doi.org]

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Osteoporosis-Pseudoglioma Syndrome

Abstract The osteoporosis-pseudoglioma syndrome (MIM 259770) is a rare autosomal recessive disorder in which bone fragility and frequent fractures are associated with serious [ncbi.nlm.nih.gov]

Ops OSTEOPOROSIS-PSEUDOGLIOMA SYNDROME OSTEOPOROSIS-PSEUDOGLIOMA SYNDROME; OPPG Osteogenesis imperfecta ocular form Osteoporosis pseudoglioma syndrome Pseudoglioma with bone [wikidata.org]

These data demonstrate substantial bone fragility despite improvements in aBMD. [ncbi.nlm.nih.gov]

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Vitamin D Deficiency

[…] by proximal muscle weakness and bone fragility. [en.wikipedia.org]

[…] disorder that occurs exclusively in adults and is characterized by proximal muscle weakness and bone fragility. [en.wikipedia.org]

bone fragility ( 10 – 12 ). [doi.org]

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Osteopenia and Osteoporosis

Osteopenia and osteoporosis (porous bone) are both terms which help to define the continuum of loss of bone density which leads to bone fragility and an increased risk of [globenewswire.com]

Osteopenia found in those whose parent(s) have fractured a hip fracture could be an early red flag of future bone fragility. [betterbones.com]

Osteoporosis leaves bones fragile, which can mean that even minor falls may cause bone fractures. [medicalnewstoday.com]

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Senile Osteoporosis

[…] ned as “a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase [books.google.de]

الصفحة 225 - a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of the skeleton, leading to enhanced bone fragility and a consequent [books.google.com]

Katharina Kerschan-Schindl, Ursula Föger-Samwald and Peter Pietschmann, Pathophysiology of Bone Fragility, Principles of Bone and Joint Research, 10.1007/978-3-319-58955-8 [doi.org]

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Spondylo-Ocular Syndrome

@article{Munns2015HomozygosityFF, title {Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects [semanticscholar.org]

Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects. [disorders.eyes.arizona.edu]

fragility, cataracts, and hearing defects. [genome.jp]

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Fracture

Osteogenesis imperfecta (OI) is a generalised connective tissue disorder associated with low bone mass, bone fragility and increased susceptibility to fractures. [ncbi.nlm.nih.gov]

The fall itself The force and direction of a fall Bone fragility Prevention of falls and fractures Reducing the force of a fall Decreasing bone fragility Resources For your [bones.nih.gov]

It makes bones fragile and more prone to fractures, especially the bones of the hip, spine, and wrist. [bones.nih.gov]

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Cystitis

Abstract In osteogenesis imperfecta (OI) because of bone fragility, deformities in load bearing regions of the body such as femoral neck and proximal femur are expected. [online.boneandjoint.org.uk]

fragility and low bone mass. [ncbi.nlm.nih.gov]

Syndrome Osteogenesis imperfecta type 7 MedGen UID: 343981 •Concept ID: C1853162 • Disease or Syndrome Osteogenesis imperfecta is a connective tissue disorder characterized by bone [ncbi.nlm.nih.gov]

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Erythropoietic Porphyria

Deficiency of this enzyme results in an accumulation of high amounts of uroporphyrin I in all tissues, leading to hemolytic anemia, splenomegaly, erythrodontia, bone fragility [ncbi.nlm.nih.gov]

The consequences of chronic haemolysis are splenomegaly, reactive erythroid hyperplasia, erythrodontia, bone fragility, extreme photosensitivity and photomutilation. [ncbi.nlm.nih.gov]

Deficiency of this enzyme results in an accumulation of high amounts of uroporphyrin I in all tissues leading to hemolytic anemia, splenomegaly, erythrodontia, bone fragility [ncbi.nlm.nih.gov]

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Kuskokwim Disease

The first case was in 1897 of a male who was described by Bruck as having bone fragility and bone contractures. [en.wikipedia.org]

Clinical description Features include osteoporosis and bone fragility, progressive joint contractures sometimes associated with pterygia, wormian bones, scoliosis due to vertebral [orpha.net]

fragility, progressive joint contractures sometimes associated with pterygia, wormian bones, scoliosis due to vertebral deformities and short stature. [malacards.org]

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Bonnemann-Meinecke-Reich Syndrome

[…] development disorder Bone dysplasia Azouz type Bone dysplasia corpus callosum agenesis Bone dysplasia lethal Holmgren type Bone dysplasia Moore type Bone fragility craniosynostosis [bioreference.net]

Bone fragility craniosynostosis proptosis hydrocephalus[?] Bone marrow failure neurologic abnormalities[?] Bone marrow failure[?] Bone neoplasms[?] [encyclopedia.kids.net.au]

Bloom syndrome Blount's disease Blue cone monochromatism Blue diaper syndrome Blue rubber bleb nevus Bo Bod-Boo BOD syndrome Boder syndrome Body dysmorphic disorder Boil Bone [bionity.com]

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Vitamin B12 Deficiency

This causes a type of anemia called megaloblastic anemia, in which the red blood cells produced in your bone marrow are large and fragile. [healthline.com]

Bones with decreased mineral density can become delicate and fragile over time, leading to an increased risk of osteoporosis. [healthline.com]

These red blood cells are too large to pass out of your bone marrow and into your circulation. [healthline.com]

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Orthostatic Syncope

This makes their bones fragile, but they don't have bone deformities. The first break usually happens when a child starts walking. [kidshealth.org]

The parents and a healthy older sister did not have similar findings of bone fragility but were described with blue sclerae. [emedicine.medscape.com]

fragility of bone. [patient.info]

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Menopause

Symptoms of menopause include: Hot flashes Night sweats Fatigue Vaginal dryness Painful sexual intercourse Decreased sex drive Osteoporosis, which makes bones weak and fragile [cancer.net]

When menopause hits, the demineralization process speeds up, leading some women to develop osteoporosis (brittle, fragile bones). (13) Cause One of estrogen’s jobs is to protect [everydayhealth.com]

After age 35, loss outpaces creation, causing overall bone loss. [everydayhealth.com]

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