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20 Possible Causes for Bone Fragility, Osteoporosis, Variable Malocclusions

  • Osteogenesis Imperfecta

    Until recently, only one report of a boy with an Sp7/Osx pathogenic variant presenting with bone fragility, limb deformities and normal hearing has been described in the literature[ncbi.nlm.nih.gov] […] recent years, denosumab, a human monoclonal antibody against receptor activator of nuclear factor κB ligand (RANKL), has become widely used as an anti-osteoclastic agent for osteoporosis[ncbi.nlm.nih.gov] The sclera have variable hues. In utero fractures are common. Limb shortening and progressive deformities can occur.[web.archive.org]

  • Osteogenesis Imperfecta Type 3

    Current research activities include: heart disease in adult osteogenesis imperfecta, the effect of nutrition on bone growth in osteogenesis imperfecta, osteoporosis in Rett[books.google.ro] The affected persons’ posture, weight and size of the head are often abnormal and these variables may contribute to the development of the Skeletal Class III malocclusion.[nature.com] Abstract BackgroundOsteogenesis imperfecta (OI) is a heritable bone fragility disorder usually caused by dominant variants in COL1A1 or COL1A2 genes.[ncbi.nlm.nih.gov]

  • Osteogenesis Imperfecta Type 5

    OMIM : 58 Osteogenesis imperfecta is a connective tissue disorder characterized by bone fragility and low bone mass.[malacards.org] What Is Osteoporosis? Osteoporosis is a condition in which the bones become less dense and more likely to break.[onlymyhealth.com] The affected persons’ posture, weight and size of the head are often abnormal and these variables may contribute to the development of the Skeletal Class III malocclusion.[nature.com]

  • Osteogenesis Imperfecta Type 16

    […] forms of OI, hypophosphatasia, and other bone fragility phenotypes that overlap with OI.[uwcpdx.org] Current research activities include: heart disease in adult osteogenesis imperfecta, the effect of nutrition on bone growth in osteogenesis imperfecta, osteoporosis in Rett[books.google.ro] The affected persons’ posture, weight and size of the head are often abnormal and these variables may contribute to the development of the Skeletal Class III malocclusion.[nature.com]

  • Osteogenesis Imperfecta Type 15

    It shows severe osteoporosis of skeleton with fractures of upper extremities, crumpled femora, flared rib cage with narrow apex and multiple beads of callus on each rib.[iofbonehealth.org] The affected persons’ posture, weight and size of the head are often abnormal and these variables may contribute to the development of the Skeletal Class III malocclusion.[nature.com] OMIM : 57 Osteogenesis imperfecta (OI) is a connective tissue disorder characterized by bone fragility and low bone mass.[malacards.org]

  • Osteogenesis Imperfecta Type 13

    OI13 is characterized by normal teeth, faint blue sclerae, severe growth deficiency, borderline osteoporosis, severe bone deformity, and recurrent fractures affecting both[malacards.org] The affected persons’ posture, weight and size of the head are often abnormal and these variables may contribute to the development of the Skeletal Class III malocclusion.[nature.com] He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years.[books.google.com]

  • Osteogenesis Imperfecta Type 2

    Osteogenesis imperfecta type 2: An inherited connective tissue disorder with extremely severe bone fragility. This is the lethal form of "brittle bone disease."[medicinenet.com] […] and radiographic findings (skeletal survey) Confirmed with DNA (blood or saliva) or protein testing (skin biopsy) Differential Non-accidental injury Idiopathic juvenile osteoporosis[medbullets.com] The affected persons’ posture, weight and size of the head are often abnormal and these variables may contribute to the development of the Skeletal Class III malocclusion.[nature.com]

  • Cleidocranial Dysplasia

    […] mineral density Increased bone density 0011001 Increased susceptibility to fractures Abnormal susceptibility to fractures Bone fragility Frequent broken bones Increased bone[rarediseases.info.nih.gov] KEYWORDS: Cleidocranial dysplasia; Dental abnormalities; Osteoporosis; RUNX2; Underdeveloped clavicles[ncbi.nlm.nih.gov] […] numbers of supernumerary teeth along with dental crowding, and malocclusion Hand abnormalities including brachydactyly, tapering fingers, and short, broad thumbs Short stature[ncbi.nlm.nih.gov]

  • Pyknodysostosis

    Cathepsin K inhibitors will be useful in pathological processes involving excess osteoclast activation and bone resorption such as osteoporosis, bone metastasis and multiple[doi.org] The patient presented the mouth deformity described by most of the reports, however, as the three cases reported by Hunt et al, presented different types of malocclusion ([jisppd.com] Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised[ncbi.nlm.nih.gov]

  • Pyle's Disease

    Cortical-bone fragility is a common feature in osteoporosis that is linked to nonvertebral fractures. Regulation of cortical-bone homeostasis has proved elusive.[ncbi.nlm.nih.gov] […] two main causes: (1) a defect in the modelling process of the vertebrae (comparable to that observed in the metaphyses) and (2) chronic pathological fractures secondary to osteoporosis[ncbi.nlm.nih.gov] […] weakness; - scoliosis, genu valgum deformity, dental / malocclusion and bone fragility; - marked expansion of the metaphyseal segments of tubular leads to an "Erlenmeyer[wheelessonline.com]

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