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213 Possible Causes for Bone Marrow Biopsy Abnormal, Pallor, Splenomegaly

  • Primary Myelofibrosis

    We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] The bone marrow trephine biopsy typically shows abnormal fibrosis of the marrow cavity.[leukaemia.org.au]

  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] […] stupor from leukostasis Left upper quadrant and left shoulder pain as a consequence of splenic infarction and perisplenitis Clinical symptoms can include the following: Pallor[emedicine.com] marrow biopsy and aspiration to look for abnormalities.[mountsinai.org]

  • Childhood Acute Lymphoblastic Leukemia

    The child redeveloped splenomegaly and fever, and then suffered an acute decompensation with hypoxemia, tachypnea, splenomegaly, and cardiac gallop.[ncbi.nlm.nih.gov] Anemia may manifest as pallor, headache, fatigue, dizziness, decreased energy or exercise tolerance, and sometimes syncope.[clinicaladvisor.com] Blood tests may include: Complete blood count (CBC), including white blood cell (WBC) count Platelet count Bone marrow biopsy Lumbar puncture ( spinal tap ) to check for leukemia[medlineplus.gov]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] Symptoms are referable to the specific cell line most affected and may include fatigue, weakness, pallor (secondary to anemia), increased infections and fever (secondary to[msdmanuals.com] Fluorescence in situ hybridization performed on the gingival biopsy specimen demonstrated the same del(20q) cytogenetic abnormality present in the bone marrow, confirming[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov] We describe a case of a 77-year-old man who presented with fatigue, pallor and lower limb pain and weakness.[ncbi.nlm.nih.gov] The diagnosis of leukemia requires confirmation of leukemic cells in the bone marrow by bone marrow biopsy and aspiration.[medical-dictionary.thefreedictionary.com]

  • Acute Myelocytic Leukemia

    Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections.[medical-dictionary.thefreedictionary.com] The main clinical picture consists of a short time period with pallor, fatigue, fever, infections and hemorrhages. Presence of all these features is not compulsory.[orpha.net] A bone marrow biopsy or a bone marrow aspiration may be done if the results of the blood tests are abnormal.[medicinenet.com]

  • Chronic Myeloid Leukemia

    Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] […] insidious, with a nonspecific “benign” stage (malaise, anorexia, weight loss) eventually giving way to accelerated or blast phases with more ominous signs, such as splenomegaly, pallor[msdmanuals.com] […] counts Tests of previous bone marrow studies to look for specific chromosome abnormalities Needle aspiration or biopsy (if necessary) for a new sample of bone marrow Molecular[rush.edu]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] The symptoms are burning pain in the feet, hands, toes and fingers, sometimes associated with pallor, erythema, or cyanosis. Occasionally, it progresses to gangrene.[symptoma.com] A bone marrow biopsy showed the presence of hyperplasia of myeloid and erythroid lineages, increased number of scattered megakarocytes without overt morphologic abnormalities[ncbi.nlm.nih.gov]

  • Thalassemia

    Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. .[mayoclinic.org] Clinical description Onset is during infancy with severe anemia, failure to thrive and progressive pallor.[orpha.net] Some infants become progressively pale (pallor).[rarediseases.org]

  • Chronic Phase of Chronic Myeloid Leukemia

    Those complaints are generally associated with anemia and splenomegaly.[symptoma.com] With disease progression, splenomegaly may increase, and pallor and bleeding occur.[merckmanuals.com] A bone marrow biopsy helps determine whether the CML is in the chronic or advanced stage.[ucsfhealth.org]

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