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26 Possible Causes for Bone Marrow Biopsy Abnormal, Polychromasia in Peripheral Blood Smear

  • Secondary Myelofibrosis

    The peripheral smear of patients with primary myelofibrosis includes red blood cells of variable shape (including tear drop cells) and size and variable degrees of polychromasia[mpncanada.com] The bone marrow trephine biopsy typically shows abnormal fibrosis of the marrow cavity.[leukaemia.org.au] Bone marrow biopsy revealed myelofibrosis. Right parathyroidectomy was performed and a parathyroid adenoma was totally excised.[ncbi.nlm.nih.gov]

  • Pancytopenia

    blood smear examination for which Leishman stain was used.[mjdrdypu.org] Bone Marrow Examination Almost always indicated in case pancytopenia unless cause is apparent. Both aspiration and biopsy are indicated.[slideshare.net] White cell abnormalities Peripheral blasts are an indication for a bone marrow biopsy and usually signify the presence of leukemia, MDS, or other infiltrative marrow disease[cancertherapyadvisor.com]

  • Sideroblastic Anemia

    Blood Smear Peripheral blood smear images .[imagebank.hematology.org] Showing marked anisopoikilocytosis, basophilic stippling, polychromasia and nRBCs.[imagebank.hematology.org] […] ineffective erythropoiesis Hereditary and Acquired Sideroblastic Anemias Published Date: 02/25/2016 Download reference case 8 year old female with congenital sideroblastic anemia Peripheral[imagebank.hematology.org]

  • Myeloma-associated Amyloidosis

    A peripheral blood smear showed normocytic normochromic anemia with anisopoikilocytosis and mild polychromasia, as well as mild neutrophilia with slight toxic granulation.[ekjm.org] Subsequent bone marrow aspirate and biopsy results found sheets of cytologically atypical plasma cells with prominent nucleoli and occasional multinucleated forms.[mdedge.com] You can also have a biopsy taken from your bone marrow which looks for abnormal plasma cells producing amyloid proteins Blood tests: Blood tests will look at the number of[myeloma.org.uk]

  • Congenital Dyserythropoietic Anemia Type 1

    Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[unboundmedicine.com] Bone marrow biopsy can reveal dyserythropoiesis, dysmorphic erythroblasts, and dysplastic platelets and megakaryocytes.[bloodgenetics.com] Peripheral blood smear shows abnormal erythrocyte size and shape as well as paucity of platelets.[bloodgenetics.com]

  • Cold Agglutinin Disease

    Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[web.archive.org] blood smear : spherocytes , polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[amboss.com] Flow cytometry studies of bone marrow are helpful in defining the presence of an abnormal monoclonal population of lymphocytes.[web.archive.org]

  • Myelofibrosis

    The peripheral smear of patients with primary myelofibrosis includes red blood cells of variable shape (including tear drop cells) and size and variable degrees of polychromasia[mpncanada.com] The bone marrow trephine biopsy typically shows abnormal fibrosis of the marrow cavity.[leukaemia.org.au] marrow examination, including aspiration and biopsy to see how your bone marrow looks (required for diagnosis) Gene testing to look at abnormalities in your cell DNA Treatment[aamds.org]

  • Normocytic Normochromic Anemia

    Peripheral blood smear shows: Microcytosis and hypochromasia. There is anisocytosis, poikilocytosis. There are pencil cells (elliptical RBCs).[labpedia.net] Bone marrow aspiration and biopsy provide direct observation and assessment of RBC precursors.[merckmanuals.com] The diagnosis of this syndrome is usually made by bone marrow biopsy ( Table 6 4 , 22 ). Myelodysplasia is treated supportively with transfusions.[aafp.org]

  • Acquired Hemolytic Anemia

    blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[amboss.com] This involves taking a small sample of bone marrow fluid (aspiration) or solid bone marrow tissue (called a core biopsy). The sample is usually taken from the hip bones.[hopkinsmedicine.org] blood smear : spherocytes, polychromasia Coombs test : positive Therapy Initial treatment of choice: glucocorticoids If glucocorticoids are unsuccessful Microangiopathic[amboss.com]

  • Acquired Sideroblastic Anemia

    Blood Smear Peripheral blood smear images .[imagebank.hematology.org] […] cells Ringed sideroblasts Cellular fragments Genetic studies of the relevant genes to detect abnormalities Bone marrow biopsy Flow cytometry analysis on bone marrow Many[dovemed.com] Miscellaneous disorders of bone marrow, including stromal and bone abnormalities. In: Foucar K (ed.)[nature.com]

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