Bone Marrow Gaucher Cells: Causes & Reasons

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Possible Causes for Bone Marrow Gaucher Cells

Gaucher Disease

[…] the liver, the spleen and the bone marrow (Gaucher cells). [orpha.net]

[…] the liver, of the spleen and the bone marrow (Gaucher cells). [orpha.net]

The deficiency in glucocerebrosidase leads to the accumulation of glucosylceramidase (or beta-glucocerebrosidase) deposits in the cells of the reticuloendothelial system of [orpha.net]

Gaucher Disease Type 2

[…] are most severely affected reduced T1 and T2 signal from involved bone marrow (due to infiltration of Gaucher cells ) bone marrow burden (BMB) score may be obtained from [radiopaedia.org]

marrow cells. [mountsinai.org]

Bone marrow transplant A bone marrow transplant, also known as a stem cell transplant, replaces bone marrow that has been damaged by Gaucher's with healthy bone marrow stem [medicalnewstoday.com]

Gaucher Disease Type 1

[…] the liver, of the spleen and the bone marrow (Gaucher cells). [orpha.net]

The median number of Gaucher cells identified during cytological assessment of bone marrow smears was 4 (range, 1-18), and the median percentage of Gaucher cells was 0.4% [ncbi.nlm.nih.gov]

The deficiency in glucocerebrosidase leads to the accumulation of glucosylceramidase (or beta-glucocerebrosidase) deposits in the cells of the reticuloendothelial system of [orpha.net]

Gaucher Disease Type 3

The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly [hon.ch]

Progressive infiltration of Gaucher cells in the bone marrow may lead to thinning of the cortex, pathologic fractures, bone pain, bony infarcts, and osteopenia. [emedicine.medscape.com]

Gaucher cells are present throughout the body, but the largest numbers are found in the spleen, liver, bone marrow, and lymph nodes causing enlargement and dysfunction of [cochranelibrary.com]

Perinatal Lethal Gaucher Disease

[…] of the liver, spleen and bone marrow (Gaucher cells). [rarediseases.info.nih.gov]

(see Bone Marrow Biopsy, [[Bone Marrow Biopsy]]) Gaucher Cell: foamy cytoplasm Occasional Fibrosis Clinical Anemia (see Anemia, [[Anemia]]) Leukopenia (see Leukopenia, [[ [mdnxs.com]

Additionally, detection of Gaucher cells in the bone marrow or genetic analysis of GBA is frequently used as an adjunct to diagnosis.Gaucher disease has been classified into [deepdyve.com]

Sea-blue histiocytosis

The distended phagocytic cells, known as Gaucher cells, are found in the spleen, liver, bone marrow, lymph nodes, tonsils, thymus, and Peyer patches. [medicalgeek.com]

Sea-blue histiocytes and Gaucher cells in bone marrow of patients with chronic myeloid leukaemia. J Clin Pathol. 1988; 41: 960-962. [meducator3.net]

Diagnosis Diagnosis was classically based on identification of Gaucher cells in a bone marrow aspirate. [path.upmc.edu]

Acute Infantile Liver Failure-Multisystemic Involvement Syndrome

[…] hepatomegaly : less marked than the degree of splenomegaly T2 : hyperintense stellate areas representing inflammation and fibrosis 3 areas of hepatic ischemia skeletal system long bones [radiopaedia.org]

Alglucerase

[…] to produce Gaucher cells which are characteristic of this disorder. [link.springer.com]

Gaucher cells are typically found in liver, spleen and bone marrow. This can lead to an enlarged spleen and liver (hepatosplenomegaly). [druglib.com]

Injections of alglucerase into Gaucher disease patients leads to elevated serum levels of the enzyme and reduction in the accumulation of glucocerebroside drugbank: pharmgkbId [wifo5-03.informatik.uni-mannheim.de]

Monoclonal Gammopathy

Bone marrow infiltration by Gaucher's cells and spleen infiltration by Gaucher cells and plasma cells was observed on cytohistologic examination. [ncbi.nlm.nih.gov]

Abstract A case of chronic non-neuronopathic Gaucher's disease is presented. The diagnosis was based on the finging of typical Gaucher cells in the bone marrow spleen. [ncbi.nlm.nih.gov]

Abstract We report a case of adult-type Gaucher's disease associated with monoclonal gammapathy of undetermined significance. [ncbi.nlm.nih.gov]

Myelophthisis

Gaucher cells clog or infiltrate the bone marrow, spleen, and liver. This disorder is inherited. [emedicine.medscape.com]

This bone marrow film at 400X magnification demonstrates carcinoma metastasis. Bone marrow cells are completely replaced by large carcinoma cells with clear nucleoli. [emedicine.medscape.com]

[…] disease, infiltration by cells with "onion-peel" cytoplasm, called Gaucher cells, is caused by a lipid storage disorder (ie, glucosylceramide lipidosis). [emedicine.medscape.com]

Gangliosidosis

Bone marrow examination may show Gaucher‐like foam cells (39%). [onlinelibrary.wiley.com]

Gaucher-like foam cells have been reported on bone marrow examination. [orpha.net]

Bone marrow frequently shows Gaucher‐like foam cells. MRI shows typical lesions in the putamen. [onlinelibrary.wiley.com]

Atypical Krabbe Disease due to Saposin A Deficiency

In some patients, the correct diagnosis can be suspected initially from a bone marrow aspirate who showing Gaucher cells. [flipper.diff.org]

In the bone marrow, infiltrating Gaucher cells lead to osteopenia, sclerosis, necrosis, and pathologic fractures ( 35 ). [basicmedicalkey.com]

marrow, and brain. [checkrare.com]

Spleen Disease

Gaucher patients may experience severe bone pain, called “bone crisis,” because Gaucher cells in the bone marrow may prevent blood from circulating properly. [cerezyme.com]

Gaucher cells accumulate primarily in the spleen, liver and bone marrow, causing organ inflammation and dysfunction. [gaucherdisease.org]

Gaucher cells accumulate primarily in the spleen, liver and bone marrow, causing organ inflammation and dysfunction. What are the Symptoms of Gaucher Disease? [gaucherdisease.org]

Infantile Sialic Acid Storage Disease

Niemann-Pick Disease Type B

Although pseudo-Gaucher cells and sea blue histiocytes can be found in bone marrow that is rapidly turning over, the combination of both numerous foam cells and sea blue histiocytes [imagebank.hematology.org]

On examination: At the age of 4 yrs, she had • neurological regression • hypotonia • facial dyskinesia • Bone-marrow examination revealed presence of storage cells Expected [slideshare.net]

Without GBA, the fat builds up in the spleen, liver, and bone marrow. Gaucher disease comes in three types, each with different symptoms. [webmd.com]

Bone Marrow Disease

cells Microscopic (histologic) images Images hosted on other servers : Various images Bone marrow Gaucher or pseudo gaucher cells Nuclear debris and erythrophagocytosis Gaucher [pathologyoutlines.com]

Because of the selective involvement of bone marrow derived cells, type 1 Gaucher disease remains the prototype of the bone marrow therapy since successful engraftment cures [scielo.br]

A bone marrow examination can help diagnose: 1 leukemia multiple myeloma Gaucher disease unusual cases of anemia other hematological diseases. [medicalnewstoday.com]

Autosomal Recessive Osteopetrosis Type 8

The initial bone marrow evaluation resulted in a dry tap. On marrow blood, no blasts, Gaucher cells, or Niemann-Pick cells were identified. [scielo.org.mx]

Cerebral Lipidosis

The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly [expertscape.com]

[…] autosomal recessive disorder caused by a deficiency of acid beta-glucosidase ( GLUCOSYLCERAMIDASE ) leading to intralysosomal accumulation of glycosylceramide mainly in cells [expertscape.com]

Juvenile Neuronal Ceroid Lipofuscinosis

Chronic Phase of Chronic Myeloid Leukemia

[…] to vascular structure Chronic phase - bone marrow smear: Pseudo-Gaucher cells Accelerated phase - peripheral blood: Pseudo-Pelger-Huët nucleus 47% basophils, 10% blasts, [pathologyoutlines.com]

[…] t(9;22) present Mature neutrophils show prominent hyposegmentation Accelerated phase - bone marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes [pathologyoutlines.com]

[…] with increased megakaryocytes; myeloid cells are primarily neutrophils PAS stain - left: perivascular accentuation of promyelocytes; right: promyelocytes and myelocytes adjacent [pathologyoutlines.com]

Necrosis of the Jaw

[…] sickle cell disease, leukemia, Gaucher's disease, thalassemia), and underwater diver's disease (from bone effects of Caisson disease, also known as dysbarism or "the bends [emedicinehealth.com]

Other risk factors for developing avascular necrosis include cigarette smoking, pregnancy, radiation and chemotherapy treatments, bone marrow and blood diseases (including [emedicinehealth.com]

Deafness-Epiphyseal Dysplasia-Short Stature Syndrome

The liver and spleen are usually quite enlarged, as are the RE cells in the bone marrow (sometimes called Gaucher cells). [rad.washington.edu]

If you then consider where the RE cells hang out, you know where to look for abnormalities in the patient with Gaucher’s disease: the liver, the spleen, and the bone marrow [rad.washington.edu]

The next concept to consider is that the marrow space in the bone is a closed space. [rad.washington.edu]

Neurological Disorder

[…] the liver, spleen and the bone marrow (Gaucher cells). [orpha.net]

The deficiency in glucocerebrosidase leads to the accumulation of glucosylceramidase (or beta-glucocerebrosidase) deposits in the cells of the reticuloendothelial system of [orpha.net]

[…] methods Diagnostic methods involve ultrasound and magnetic resonance imaging (MRI) for initial evaluation and subsequent monitoring of hepatosplenomegaly, radiography and bone [orpha.net]

Blast Phase of Chronic Myeloid Leukemia

Imiglucerase

Gaucher cells are typically found in liver, spleen and bone marrow. This can lead to an enlarged spleen and liver (hepatosplenomegaly). [drugbank.ca]

The group receiving a higher dose of enzyme therapy had a more robust clearance of bone marrow infiltration of Gaucher cells and reductions in the biomarker chitotriosidase [nature.com]

cells. [drugbank.ca]

Bone Necrosis

marrow where large polyhedral Gaucher cells accumulate Their pressure on bone sinusoids may ® bone necrosis Tendency for lesions to become infected ® septicaemia Associated [flinders.edu.au]

[…] disease sickle cell disease caisson disease ("the bends") Pathogenesis impaired blood supply leads to infarction of the associated bone and bone marrow vascular insufficiency [medbullets.com]

Leukoerythroblastic Anemia

Gaucher cells clog or infiltrate the bone marrow, spleen, and liver. This disorder is inherited. [emedicine.medscape.com]

This bone marrow film at 400X magnification demonstrates carcinoma metastasis. Bone marrow cells are completely replaced by large carcinoma cells with clear nucleoli. [emedicine.medscape.com]

[…] disease, infiltration by cells with "onion-peel" cytoplasm, called Gaucher cells, is caused by a lipid storage disorder (ie, glucosylceramide lipidosis). [emedicine.medscape.com]

Lethal Neonatal Spasticity - Epileptic Encephalopathy

Bone marrow smear showing Gaucher cell. [slideshare.net]

[…] enzyme activity in peripheral blood leukocytes or hepatocytes – Gaucher cells in bone marrow - pathognomic • Management - Symptomatic treatment includes partial or total [slideshare.net]

• Vertical oculomotor apraxia, as described in Niemann-Pick disease, may occur in late-onset Gaucher disease as well. 51. • Diagnosis – – Assay of acid b –glucosylceramidase [slideshare.net]

Avascular Necrosis

[…] disease, and systemic lupus erythematosus. - biblioghraphy : Avascular necrosis of bone: a common serious complication of allogeneic bone marrow transplantation. [pitt.edu]

Other risk factors for developing avascular necrosis include cigarette smoking, pregnancy, radiation and chemotherapy treatments, bone marrow and blood diseases (including [emedicinehealth.com]

Lichtenstein Syndrome

The liver and spleen are usually quite enlarged, as are the RE cells in the bone marrow (sometimes called Gaucher cells). [rad.washington.edu]

[…] macrophages, the Gaucher cells, is associated with cellular necrosis, fibrous proliferation, resorption of the tra-becular bone, and bone marrow dysfunction with anemia and [rrnursingschool.biz]