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12 Possible Causes for Bone Marrow with Decreased Iron Stores, Plummer-Vinson Syndrome

  • Plummer-Vinson Syndrome

    The authors report the case of a 6 year old with Plummer-Vinson syndrome.[] Plummer-Vinson syndrome can be treated effectively with iron supplementation and mechanical dilation.[] OBJECTIVE: Very few cases of Plummer-Vinson syndrome affecting males have been reported.[]

  • Iron Deficiency Anemia

    The most used name is Plummer-Vinson syndrome, named after Henry Stanley Plummer (1874–1936) and Porter Paisley Vinson (1890–1959) who were physicians on the staff of the[] Iron depletion: The first thing that occurs is decreased bone marrow iron (seen as hemosiderin on Prussian-blue stained bone marrow smears) as iron stores are used to maintain[] iron stores in the bone marrow.[]

  • Iron Deficiency

    Symptoms of iron deficiency include: fatigue dizziness/lightheadedness pallor hair loss twitches irritability weakness pica brittle or grooved nails hair thinning PlummerVinson[] In the first stage, iron requirement exceeds intake, causing progressive depletion of bone marrow iron stores.[] This is the Paterson-Brown-Kelly syndrome (or Plummer-Vinson syndrome) and there is an association with oesophageal carcinoma.[]

  • Microcytic Anemia

    Koilonychia- "spoon nails" [koi-loh-nik-ee-uh] What does Plummer-Vinson Syndrome look like in severe iron deficiency anemia?[] In the first stage, iron requirement exceeds intake, causing progressive depletion of bone marrow iron stores.[] Erythrocyte Protoporhyrin Because less haem to bind to protoporhyrin to make Hb Bone marrow biopsy Little or no iron on marrow when deficient Rx Underlying cause Ferrous sulfate Plummer-Vinson[]

  • Posthemorrhagic Anaemia of the Newborn

    Plummer-Vinson syndrome Sideropenic dysphagia 280.9 Iron deficiency anemia, unspecified Anemia: achlorhydric chlorotic idiopathic hypochromic iron [Fe] deficiency NOS 281[] […] most common type of normocytic anemia Anemia of Chronic Disease/Inflammation Pathophysiology - Increased accumulation of iron stores in macrophages - Decreased delivery of[] Plummer-Vinson syndrome D50.8 Other iron deficiency anemias Iron deficiency anemia due to inadequate dietary iron intake D50.9 Iron deficiency anemia, unspecified D51 Vitamin[]

  • Constitutional Megaloblastic Anemia due to Folate Metabolism Disorder

    […] of neuroepithelial tissue Pineoblastoma Pineocytoma Plaque-form urticaria pigmentosa Plasma cell tumor Plasmacytoma Pleomorphic liposarcoma Pleomorphic rhabdomyosarcoma Plummer-Vinson[] […] from the stores, decrease the responsiveness of the bone marrow to erythropoetin.[] […] brittle nails, cheliosis, smooth tongue, formation of esophageal webs (Plummer-Vinson syndrome) Laboratory findings in iron deficiency anemia?[]

  • Gaisbock's Syndrome

    Plummer vinson syndrome/Paterson brown kelly syndrome -Combination of symptomatic hypo pharyngeal webs and iron deficiency anemia in mddle aged female.Radiological finding-web[] stores are decreased, often absent Post PV / spent phase: (Figures D - G) Leukoerythroblastosis Overt bone marrow reticulin and collagen fibrosis Osteosclerosis usually prominent[] marrow Panhyperplasia Erythroid hyperplasia N Iron stores N N Chromosome studies Abnormal (50%) N N LABORATORY DIFFERENTIAL OF POLYCYTHEMIA # Hb, # Hct, # RBC ABSOLUTE Red[]

  • Red Blood Cell Disorder

    . • First described by Plummer and VinsonPlummer-Vinson syndrome is potentially serious because pharyngeal and intraoral carcinoma are more common in these patients. •[] Its synthesized by the bone marrow macrophages and hepatocytes. Serum iron levels correlate with ferritin stores in the macrophages.[] Decreased serum ferritin in diagnostic of iron deficiency anemia. Hemosiderin is a breakdown product of ferritin. 11 Iron studies.[]

  • Anemia of Chronic Disease

    Rare symptoms & signs: -Glossitis or angular cheilitis -Dysphagia due to esophageal web (Plummer-Vinson syndrome) -Koilonychia; "Spoon" fingernails -Pica -soreness of mouth[] Hepcidin is a key that locks up iron in the bone marrow and prevents it’s release to transferrin. That’s why, ferritin is increased. (Stores are there, but unavailable!)[] Bone marrow iron stores are usually increased. Ferritin (an acute phase reactant) may be elevated in inflammation.[]

  • Inadequate Dietary Intake of Iron

    Although it is a rare condition, Plummer-Vinson syndrome (IDA associated with difficulty swallowing, enlarged spleen, and spooning of the nails) may occur in severe cases[] marrow decrease.[] Iron depletion and deficiency progresses through several stages [ 8 ]: Mild deficiency or storage iron depletion: Serum ferritin concentrations and levels of iron in bone[]

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