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72 Possible Causes for Bone Marrow with Foam Cells

  • Niemann-Pick Disease Type B

    Bone marrow biopsy showed plenty of foam cells and sphingomyelinase level was low, thus conforming our diagnosis.[ncbi.nlm.nih.gov] Although pseudo-Gaucher cells and sea blue histiocytes can be found in bone marrow that is rapidly turning over, the combination of both numerous foam cells and sea blue histiocytes[imagebank.hematology.org] cells in the bone marrow aspirate.[ncbi.nlm.nih.gov]

  • Niemann-Pick Disease

    Bone marrow biopsy showed plenty of foam cells and sphingomyelinase level was low, thus conforming our diagnosis.[ncbi.nlm.nih.gov] Foam cells were present in the bone marrow aspirate too, that contained also sea-blue histiocytes.[ncbi.nlm.nih.gov] marrow will show abnormal foam cells) Type C: biochemical test - skin biopsy taken and the fibroblasts are tested for their ability to handle cholesterol (esterification[en.wikibooks.org]

  • Propionic Acidemia

    marrow vacuolization , foam cells or granules.[vdocuments.site] […] vacuolization, foam cells or granules.[vdocuments.mx] . • DNA studies • Neuro-radiology • • Blood glucose, ammonia, bicarbonate and pH Peripheral Blood smear – WBC or bone marrow vacuolization , foam cells or granules.[nanopdf.com]

  • Bone Marrow Aspiration

    Typically in patients with NPC, macrophages with abnormal cholesterol storage, so called foam cells, can be detected in the bone marrow.[ncbi.nlm.nih.gov] In cholestatic patients with splenomegaly, a bone marrow aspirate has been advocated as a relatively accessible tissue to demonstrate storage phenomena.[ncbi.nlm.nih.gov]

  • Tangier Disease

    marrow foam cells), was misdiagnosed as Niemann-Pick C (NPC) and treated with miglustat (300 mg/day), normalizing neurological symptoms and improving skin lesions and legs[ncbi.nlm.nih.gov] Subsequently, the diagnosis of homozygous Tangier disease was also established by biopsy of the patient’s bone marrow, showing the presence of foam cells (Figure 1 ).[circ.ahajournals.org] Haematological parameters showed the presence of pancytopenia (haemoglobin 10.2 g/dl, leukocytes 3700/ul, platelet 109000/ul), a bone marrow biopsy evidenced foam cells, interpreted[ojrd.biomedcentral.com]

  • Wolman Disease

    […] acid cholesteryl ester hydrolase deficiency disseminated organ foam cell infiltration bone marrow foam cells vacuolated blood lymphocytes liver, adrenal, spleen , lymph nodes[humpath.com] Differential diagnosis In Wolman disease foam cells are found in bone marrow and vacuolated lymphocytes in peripheral blood, as in Niemann-Pick disease type A and B (acid[bredagenetics.com] Hypercholesterolemia, bone marrow foam cells, and vacuolated blood lymphocytes may also be observed.[emedicine.medscape.com]

  • Sea-blue histiocytosis

    The bone marrow shows “foam cells,” which are large histiocytes with abundant finely vacuolated or “soap bubble” cytoplasm (see Fig. 7.9B ).[obgynkey.com]

  • Fish-Eye Disease

    Red blood cells may have increased cholesterol content and foam cells are found in bone marrow and in the glomerular tufts of the kidney.[disorders.eyes.arizona.edu]

  • Cholesterol Ester Storage Disease

    cells in bone marrow and other tissues, and vacuolated lymphocytes in peripheral blood; autosomal recessive inheritance, caused by mutation in the lysosomal acid lipase gene[medical-dictionary.thefreedictionary.com] Peripheral blood lymphocytes are vacuolated and foam cells are present in the bone marrow. Approximately 50% of infants have adrenal calcifications.[mayomedicallaboratories.com] Differential diagnosis In Wolman disease foam cells are found in bone marrow and vacuolated lymphocytes in peripheral blood, as in Niemann-Pick disease type A and B (acid[bredagenetics.com]

  • Gangliosidosis GM1

    Gaucher-like foam cells have been reported on bone marrow examination.[orpha.net]

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