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22 Possible Causes for Bone Marrow with Giant Metamyelocytes

  • Megaloblastic Anemia

    White blood cells show giant metamyelocytes in the bone marrow are a characteristic feature. Megakaryocytes are also abnormal.[labpedia.net] Bone marrow examination showed megaloblastic change in the erythroblasts and myeloid hyperplasia.[ncbi.nlm.nih.gov] There are megaloblasts which are large and abnormal RBCs precursors in the bone marrow and macrocytes in the peripheral blood smear.[labpedia.net]

  • Pernicious Anemia

    Bone marrow biopsy: The abnormalities seen in bone marrow include large cell size, giant metamyelocytes and marked erythroid hyperplasia.[symptoma.com] In B12 and folate deficiency, megaloblasts and giant metamyelocytes (early granulocyte precursors) are seen. [ 9 ] Gastric secretions Total gastric secretions are reduced[patient.info] However, bone marrow aspiration may be necessary to narrow the differential diagnosis, especially if myelodysplasia, aplastic anaemia, myeloma, or other marrow disorders are[patient.info]

  • Vitamin B12 Deficiency

    In B12 and folate deficiency, megaloblasts and giant metamyelocytes (early granulocyte precursors) are seen. [ 9 ] Gastric secretions Total gastric secretions are reduced[patient.info] However, bone marrow aspiration may be necessary to narrow the differential diagnosis, especially if myelodysplasia, aplastic anaemia, myeloma, or other marrow disorders are[patient.info]

  • Megaloblastic Anaemia in Pregnancy

    Article First Online: 20 October 2008 Summary Of seventeen cases of megaloblastic anaemia treated with large doses of vitamin B12, thirteen had a reticulocyte response and haematological improvement and 4 responded to folic acid when vitamin B12 had failed. In four cases responding to vitamin B12 folic acid failed to[…][link.springer.com]

  • Inadequate Dietary Intake of Folic Acid

    Although scientists are not sure why the neural tubes fail to develop or close correctly in some infants, they think that the explanation behind spina bifida may be genetic, nutritional or environmental – or a combination of these causes. There does appear to be some definite risk factors that increase the chance[…][mychildwithoutlimits.org]

  • Methotrexate

    A woman aged 77 years with a history of rheumatoid arthritis (RA) presented with inflammatory colitis confined to her rectum, which was incidentally found by a screening colonoscopy. Histopathological examination of colonic biopsies showed non-specific inflammatory infiltrates of lymphocytes, the cause of which was[…][ncbi.nlm.nih.gov]

  • Malabsorption of Vitamin B12

    Abstract A 3 year old girl with Down's syndrome became lethargic and withdrawn, and investigations showed a specific malabsorption of vitamin B12 without proteinuria.[ncbi.nlm.nih.gov]

  • Folate-Deficiency Anemia

    BACKGROUND: The United States implemented mandatory folic acid fortification of enriched cereal grains in 1998. Although several studies have documented the resulting decrease in anemia and folate deficiency, to our knowledge, no one has determined the prevalence of folate-deficiency anemia after fortification.[…][ncbi.nlm.nih.gov]

  • Glossitis

    bone marrow with megaloblasts with giant and abnormal metamyelocytes are seen. [3] [4] Serum unconjugated bilirubin [5] These levels are high because marrow cell breakdown[explainmedicine.com] In iron deficiency anemia, microcytic anemia is seen. [2] [3] [4] Bone marrow aspiration [3] [4] This is carried out in anemia, and in vitamin B12 deficiency anemia, hypercellular[explainmedicine.com]

  • Atrophic Glossitis

    bone marrow with megaloblasts with giant and abnormal metamyelocytes are seen. [3] [4] Serum unconjugated bilirubin [5] These levels are high because marrow cell breakdown[explainmedicine.com] In iron deficiency anemia, microcytic anemia is seen. [2] [3] [4] Bone marrow aspiration [3] [4] This is carried out in anemia, and in vitamin B12 deficiency anemia, hypercellular[explainmedicine.com]

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