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27 Possible Causes for Bone Marrow with Giant Metamyelocytes

  • Pernicious Anemia

    Bone marrow biopsy: The abnormalities seen in bone marrow include large cell size, giant metamyelocytes and marked erythroid hyperplasia.[symptoma.com] In B12 and folate deficiency, megaloblasts and giant metamyelocytes (early granulocyte precursors) are seen. [ 9 ] Gastric secretions Total gastric secretions are reduced[patient.info] However, bone marrow aspiration may be necessary to narrow the differential diagnosis, especially if myelodysplasia, aplastic anaemia, myeloma, or other marrow disorders are[patient.info]

  • Megaloblastic Anemia

    White blood cells show giant metamyelocytes in the bone marrow are a characteristic feature. Megakaryocytes are also abnormal.[labpedia.net] Bone marrow examination showed megaloblastic change in the erythroblasts and myeloid hyperplasia.[ncbi.nlm.nih.gov] Figure 2: Bone marrow aspiration smear showing megaloblasts with open sieve like chromatin and royal blue cytoplasm (Leishman, 100) Click here to view Figure 3: (a) Bone marrow[mjdrdypu.org]

  • Megaloblastic Anaemia in Pregnancy

    Article First Online: 20 October 2008 Summary Of seventeen cases of megaloblastic anaemia treated with large doses of vitamin B12, thirteen had a reticulocyte response and haematological improvement and 4 responded to folic acid when vitamin B12 had failed. In four cases responding to vitamin B12 folic acid failed to[…][link.springer.com]

  • Inadequate Dietary Intake of Folic Acid

    Megaloblastic anemia due to folic acid deficiency is commonly due to: (AI 2006) A Inadequate dietary intake B Defective intestinal absorption C Absence of folic acid binding protein in serum D Absence of glutamic acid in the intestine Ans. A Inadequate dietary intake Folic acid deficiency 1. Dietary cause 2.[…][gradestack.com]

  • Malabsorption of Vitamin B12

    A Syrian family is described with three children who had inherited selective vitamin B12 malabsorption associated with proteinuria. (Imerslund-Grasbeck syndrome). Although inherited the defect was apparently not present at birth. A third child had less severe vitamin B12 malabsorption, was not vitamin B12 deficient and[…][ncbi.nlm.nih.gov]

  • Glossitis

    bone marrow with megaloblasts with giant and abnormal metamyelocytes are seen. [3] [4] Serum unconjugated bilirubin [5] These levels are high because marrow cell breakdown[explainmedicine.com] In iron deficiency anemia, microcytic anemia is seen. [2] [3] [4] Bone marrow aspiration [3] [4] This is carried out in anemia, and in vitamin B12 deficiency anemia, hypercellular[explainmedicine.com]

  • Vitamin B12 Deficiency

    Homocysteine (Hcy) is an independent risk factor for predisposing to atherosclerosis and endothelial dysfunction. Hcy levels increase with Vitamin B12 deficiency. The aim of this study was to investigate the association between carotid intima-media thickness (CIMT) and the autonomic modulation of heart rate[…][ncbi.nlm.nih.gov]

  • Methotrexate

    The increased use of biologic agents over the past two decades has led to a reappraisal of the role of the immunomodulators (thiopurines and methotrexate) in the treatment of inflammatory bowel disease. The purpose of this review is to summarize recent data on the use of thiopurines and methotrexate either as[…][ncbi.nlm.nih.gov]

  • Folate-Deficiency Anemia

    The United States implemented mandatory folic acid fortification of enriched cereal grains in 1998. Although several studies have documented the resulting decrease in anemia and folate deficiency, to our knowledge, no one has determined the prevalence of folate-deficiency anemia after fortification. We determined[…][ncbi.nlm.nih.gov]

  • Folic Acid Deficiency

    giant metamyelocytes in bone marrow smears than the remaining 23 patients (P less than 0.05).[ncbi.nlm.nih.gov] The 18 patients with folic acid deficiency had a significantly higher rate of megaloblasts, binucleate erythropoietic precursors, Howell-Jolly bodies, giant myelocytes, and[ncbi.nlm.nih.gov]

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