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12 Possible Causes for Bone Marrow with Giant Metamyelocytes, Hematocrit Decreased, Pernicious Anemia not due to Intrinsic Factor Deficiency

  • Pernicious Anemia

    Technically, the term "pernicious anemia" refers to vitamin B12 deficiency due to a lack of intrinsic factor.[web.archive.org] […] in serum vitamin B 12 and the decline in hematocrit.[aafp.org] Bone marrow biopsy: The abnormalities seen in bone marrow include large cell size, giant metamyelocytes and marked erythroid hyperplasia.[symptoma.com]

  • Megaloblastic Anemia

    Megaloblastic anemia that arises due to lack of intrinsic factor is called pernicious anemia .[medindia.net] Hematocrit – decreased3. RBC count – decreased/normal4. MCV - 100fl ( normal 82-98fl)5. MCH –increased6. MCHC – NORMAL7. Reticulocytopenia.8.[slideshare.net] White blood cells show giant metamyelocytes in the bone marrow are a characteristic feature. Megakaryocytes are also abnormal.[labpedia.net]

  • Vitamin B12 Deficiency

    In pernicious anemia, the intrinsic factor necessary for vitamin B12 absorption is lacking, often due to an autoimmune factor.[livestrong.com] […] in serum vitamin B 12 and the decline in hematocrit.[aafp.org] In B12 and folate deficiency, megaloblasts and giant metamyelocytes (early granulocyte precursors) are seen. [ 9 ] Gastric secretions Total gastric secretions are reduced[patient.info]

  • Subacute Combined Degeneration of Spinal Cord

    anemia 2016 2017 2018 2019 Billable/Specific Code Applicable To Vegan anemia D51.3 ) pernicious ( ICD-10-CM Diagnosis Code D51.0 Vitamin B12 deficiency anemia due to intrinsic[icd10data.com] The bone marrow is hypercellular with megaloblastic erythroid hyperplasia and giant metamyelocytes.[scielo.br] , [3] and copper deficiency. [4] It is usually associated with pernicious anemia.[ipfs.io]

  • Megaloblastic Anaemia in Pregnancy

    It results in a malignant condition named pernicious anemia due to major vitamin B12 deficiency as the intrinsic factor is responsible for absorbing the vitamin in the intestine[pregmed.org] This accelerates erythropoiesis, but hemoglobin concentration and hematocrit decrease. 3. Iron metabolism In adult men, there is usually little iron loss from the body.[intechopen.com] However, a disproportionate increase in plasma volume results in hemodilution (hydremia of pregnancy): hematocrit (Hct) decreases from between 38% and 45% in healthy women[merckmanuals.com]

  • Congenital Vitamin B12 Deficiency

    anemia Biermer anemia Pernicious (congenital) anemia Congenital intrinsic factor deficiency D51.1 Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption[icd10coded.com] […] in serum vitamin B 12 and the decline in hematocrit.[aafp.org] The additional finding of hypersegmented polymorphonuclear neutrophils should point to the likelihood of megaloblastic anemia, and a bone marrow aspirate could clinch the[cancertherapyadvisor.com]

  • Congenital Intrinsic Factor Deficiency

    anemia - Gastric intrinsic factor deficiency - Hereditary juvenile meganoblastic anemia due to intrinsic factor deficiency - IFD - Intrinsic factor deficiency Classification[csbg.cnb.csic.es] […] in serum vitamin B 12 and the decline in hematocrit.[aafp.org] Bone Marrow  Hypercellular marrow  Megaloblastic erythroid hyperplasia  Giant metamyelocytes Due to slowing of DNA synthesis and delayed nuclear maturation Methionine deficiency[slideshare.net]

  • Autoimmune Pangastritis

    […] to loss of negative feedback) G cell hyperplasia hypergastrinem ia Autoantibodies against intrinsic factor vitamin B 12 deficiency pernicious anemia EMAG Helicobacter-associated[amboss.com] marrow Hypercellular bone marrow Increased erythroid precursors Open, immature nuclear chromatin Dyssynchrony between maturation of cytoplasm and nuclei Giant bands, metamyelocytes[wjgnet.com] anemia , a megaloblastic anemia arising from vitamin B 12 malabsorption as a consequence of intrinsic factor deficiency, [7,8] or the iron deficiency anemia due to iron malabsorption[journals.lww.com]

  • Congenital Malabsorption of Folic Acid

    […] thyroid disease -Congenital deficiency of intrinsic factor or congenital selective Vit B12 malabsorption due to defects of the receptor sites in the distal ileum Why can B12[quizlet.com] […] in serum vitamin B 12 and the decline in hematocrit.[aafp.org] The additional finding of hypersegmented polymorphonuclear neutrophils should point to the likelihood of megaloblastic anemia, and a bone marrow aspirate could clinch the[thecardiologyadvisor.com]

  • Macrocytic Anemia

    Causes Pernicious anemia- inability of GI tract to absorb B12 due to a missing transport protein called intrinsic factor #1 cause of B12 deficiency Most often caused by an[physicianassistantexamreview.com] The differential white blood count shows a decrease in most types of cells but not lymphocytes .[labtestsonline.org] The additional finding of hypersegmented polymorphonuclear neutrophils should point to the likelihood of megaloblastic anemia, and a bone marrow aspirate could clinch the[cancertherapyadvisor.com]