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24 Possible Causes for Bone Marrow with Giant Metamyelocytes, Megaloblastic Anemia

  • Megaloblastic Anemia

    Megaloblastic anemia (or megaloblastic anaemia ) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis during red blood cell production[] White blood cells show giant metamyelocytes in the bone marrow are a characteristic feature. Megakaryocytes are also abnormal.[] Bone marrow examination showed megaloblastic change in the erythroblasts and myeloid hyperplasia.[]

  • Vitamin B12 Deficiency

    Megaloblastic anemias are a subgroup of macrocytic anemias, in which distinctive morphologic abnormalities occur in red cell precursors in bone marrow, namely megaloblastic[] Deficiency of vitamin B12 causes megaloblastic anemia and nervous system demyelination.[] Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia.[]

  • Megaloblastic Anaemia in Pregnancy

    The rate of clearance of folic acid from plasma was more rapid in patients with megaloblastic anemia of pregnancy.[] How can Megaloblastic Anemia be Prevented?[] Megaloblastic Anemia Symptoms Most cases of megaloblastic anemia gradually develop.[]

  • Inadequate Dietary Intake of Folic Acid

    Megaloblastic anemia due to folic acid deficiency is commonly due to: (AI 2006) A Inadequate dietary intake B Defective intestinal absorption C Absence of folic acid binding[] Lack of folic acid leads to a type of blood disorder called megaloblastic anemia . There are many types of anemia ]] .[] Stimulates production of RBCs, WBCs, and platelets in patients with megaloblastic anemias.[]

  • Malabsorption of Vitamin B12

    An 8-year-old boy with megaloblastic anemia due to selective vitamin B12 malabsorption is presented.[] Clinically the patient presented the characteristic intrinsic factor independent vitamin B12 malabsorption with severe megaloblastic anemia and a benign nephropathy with non-selective[] […] syndrome Megaloblastic anemia due to vegetarianism Megaloblastic anemia due to vitamin B 12 deficiency Megaloblastic anemia due to vitamin B 12 malabsorption with proteinuria[]

  • Folate-Deficiency Anemia

    These data suggest that folate deficiency was the cause of the megaloblastic anemia observed in these patients.[] You get Macrocytic/Megaloblastic Anemia with Hypersegmented Neutrophils and increased Homocysteine levels.[] […] deficiency Anemia, megaloblastic, folate deficiency Dietary folate deficiency anemia Drug induced folate deficiency anemia Folate deficiency anemia, drug-induced Megaloblastic[]

  • Folic Acid Deficiency

    giant metamyelocytes in bone marrow smears than the remaining 23 patients (P less than 0.05).[] Cell-mediated immunity has been studied in patients with 1) megaloblastic anemia of folic acid deficiency, 2)megaloblastic anemia of pregnancy, or 3) iron-deficiency anemia[] anemia, but in most infants megaloblastic anemia developed after a series of infections, even though the intake of ascorbic acid was unquestionably adequate.[]

  • Pernicious Anemia

    In rare cases, megaloblastic anemia is the result of inherited problems: Thiamine-responsive megaloblastic anemia syndrome (TRMA) is a rare inherited megaloblastic anemia[] Bone marrow biopsy: The abnormalities seen in bone marrow include large cell size, giant metamyelocytes and marked erythroid hyperplasia.[] In B12 and folate deficiency, megaloblasts and giant metamyelocytes (early granulocyte precursors) are seen. [ 9 ] Gastric secretions Total gastric secretions are reduced[]

  • Glossitis

    bone marrow with megaloblasts with giant and abnormal metamyelocytes are seen. [3] [4] Serum unconjugated bilirubin [5] These levels are high because marrow cell breakdown[] Vitamin B12 deficiency results in megaloblastic anemia and may present as glossitis.[] In iron deficiency anemia, microcytic anemia is seen. [2] [3] [4] Bone marrow aspiration [3] [4] This is carried out in anemia, and in vitamin B12 deficiency anemia, hypercellular[]

  • Pancytopenia

    Highest MCV noted was 135fL seen in megaloblastic anemia.[] […] in bone marrow of all patients of megaloblastic anemia.[] Patients with HFM frequently present with neurodevelopmental delay and megaloblastic anemia.[]

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