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26 Possible Causes for Bone Marrow with Granulocytes Maturation Arrest, Neutrophil Count Decreased, Pancytopenia

  • Radiation Exposure

    […] doses cause initial anorexia, lethargy and vomiting then normality for several weeks followed by vomiting, nasal discharge, dysentery, recumbency, septicemia and a profound pancytopenia[medical-dictionary.thefreedictionary.com]

  • Pernicious Anemia

    The outcome was rapidly marked by febrile pancytopenia and ataxia leading to the diagnosis of pernicious anemia.[ncbi.nlm.nih.gov] Although her anemia was categorized as "normocytic, normochromic" by an electronic particle counter, evaluation of the pancytopenia confirmed unsuspected pernicious anemia[ncbi.nlm.nih.gov] The cobalamin deficiency was revealed by macrocytic pancytopenia.[ncbi.nlm.nih.gov]

  • Chemotherapy

    Our study showed that the change trend of monocyte count was the same as that of neutrophil count and that the number of days when monocytes initial decrease/are in nadir[ncbi.nlm.nih.gov] 2.36 days earlier than that in neutrophil count.[ncbi.nlm.nih.gov] The time of initial decrease in monocyte count was 1.39 days earlier; the nadir in monocyte count occurred 3.81 days earlier, and the final increase in monocyte count was[ncbi.nlm.nih.gov]

  • Acute Radiation Sickness

    The patient is asymptomatic but full blood examination will show characteristic changes, with lymphocyte depression and gradual decrease in neutrophil and platelet counts.[health.gov.au] During the latent period for this type, the lymph nodes, spleen and bone marrow begin to atrophy, leading to underproduction of all types of blood cells (pancytopenia).[rarediseases.org] […] doses cause initial anorexia, lethargy and vomiting then normality for several weeks followed by vomiting, nasal discharge, dysentery, recumbency, septicemia and a profound pancytopenia[medical-dictionary.thefreedictionary.com]

  • Azathioprine

    […] in WBC.3,4,8 Despite this, some patients still experienced significant drops in neutrophil counts to References: Azathioprine tablets (Azasan) product package insert.[ebmconsult.com] However, pancytopenia and severe combined immune deficiency-like disease have been reported in infants whose mothers received azathioprine throughout pregnancy.[ncbi.nlm.nih.gov] The resulting blood dyscrasias, leucopenia, thrombocytopenia or pancytopenia, can be life threatening.[medsafe.govt.nz]

  • Vitamin B12 Deficiency

    Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia.[ncbi.nlm.nih.gov] Subacute combined spinal cord degeneration and pancytopenia are two serious and rarely displayed consequences that appear in severe deficits.[ncbi.nlm.nih.gov] We describe this patient to remind readers that B12 deficiency may cause severe pancytopenia and regression of motor functions.[ncbi.nlm.nih.gov]

  • Methotrexate

    At 24 months, decreases in mean absolute neutrophil counts and increases in mean serum creatinine levels were seen in all groups.[nejm.org] […] fatigue, dizziness Hepatotoxicity: elevated transaminases (up to 15%), cirrhosis (generally only after prolonged use) Hematologic (1-3%): anemia, leukopenia, thrombocytopenia, pancytopenia[rheumtutor.com] Pancytopenia after a single intradermal infiltration of methotrexate. J Drugs Dermatol 2005;4:648-51.[aad.org]

  • Infectious Mononucleosis

    We report a patient with rheumatoid arthritis (RA) who developed cytomegalovirus (CMV)-induced infectious mononucleosis-like syndrome (IMLS) while being treated with methotrexate and infliximab. She suddenly developed intermittent high fever and general fatigue with liver dysfunction, remarkable lymphocytosis and[…][ncbi.nlm.nih.gov]

  • Kostmann Syndrome

    Examination of the bone marrow revealed normal cellularity of the granulocyte precursors with arrested maturation. These findings are consistent with Kostmann syndrome.[ncbi.nlm.nih.gov] Autosomal recessive KS, as described by Kostmann, has a neutrophil count less than 200 cells per microliter.[symptoma.com] Classification of the Inherited Bone Marrow Failure Syndromes Pancytopenia Fanconi's anemia, Shwachman-Diamond syndrome, dyskeratosis congenita, cartilage-hair hypoplasia,[sickkids.ca]

  • Agranulocytosis

    Bone marrow aspiration, which is rarely performed, typically shows a normocellular marrow with late granulocytic maturation arrest.[clinchem.org] Background: Nonchemotherapy drug–induced agranulocytosis is a rare adverse reaction that is characterized by a decrease in peripheral neutrophil count to less than 0.5 10[annals.org] JAMA 188:817–824 Google Scholar Kelton JG, Huang AT, Mold N, Logue G, Rosse WF (1979) The use of in vitro technics to study drug-induced pancytopenia.[link.springer.com]

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