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15 Possible Causes for Bone Marrow with Increased Iron Stores, Burr Cell, Thrombotic Thrombocytopenic Purpura

  • Congenital Heinz Body Hemolytic Anemia

    Burr Cells: Liver disease Renal disease Severe burns Bleeding gastric ulcers Maybe artifact Echinocyte (Burr Cell) Acanthocyte vs Echinocyte Howell-Jelly: are intracellular[] thrombocytopenic purpura ) Presence of a type of immature red blood cells called normoblasts may be due to: Cancer that has spread to bone marrow Blood disorder called erythroblastosis[] thrombocytopenic purpura disseminated intravascular coagulation renal graft rejection COPD Acanthocytes resemble spurs on cowboy boots, but they have uneven projections ([]

  • Uremic Anemia

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[] Thrombotic thrombocytopenic purpura (similar to hemolytic-uremic syndrome ) involves nonimmunologic platelet destruction.[] Diagnosis Peripheral blood smear establishes the presence of MAHA by schistocytes, burr cells, helmet cells etc.[]

  • Acquired Toxic Hemolytic Anemia

    Membrane Burr Cells (Echinocytes) Spur Cells (Acanthocytes) Stomatocytes: mouth-shaped area of central pallor Target Cells: due to decreased lecithin/cholesterol acyltransferase[] Hemolytic Uremic Syndrome (HUS) and Thrombotic Thrombocytopenic Purpura (TTP) are the prototype MAHAs and likely represent a continuum of disease caused by a variety of etiological[] I can also be associated with hematologic diseases such as disseminated intravascular coagulation; hemolytic-uremic syndrome; and thrombotic thrombocytopenic purpura.[]

  • Anemia of Chronic Disease

    cells Chronic renal failure Spherocytes, fragments Hemolytic diseases Dysplastic changes Myelodysplasia Reticulocyte count 1% Inadequate production in presence of anemia[] Bone marrow iron stores are usually increased. Ferritin (an acute phase reactant) may be elevated in inflammation.[] Severe red cell fragmentation Microangiopathic hemolytic anemias: Malfunctioning mechanical heart valve, disseminated intravascular coagulation, thrombotic thrombocytopenic[]

  • Anemia

    Burr cells accompany renal failure and spur cells accompany severe liver disease.[] Because iron is stored in the bone marrow, this test can provide a good idea of how much iron is in the body. But bone marrow aspirations are not done very often.[] Hemolytic anemia This type of anemia includes sickle cell anemia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome, aortic valve prosthesis, disseminated[]

  • Red Blood Cell Disorder

    Burr Cells: Liver disease Renal disease Severe burns Bleeding gastric ulcers Maybe artifact Echinocyte (Burr Cell) Acanthocyte vs Echinocyte Howell-Jelly: are intracellular[] Ferritin: soluble iron binding storage protein also helps to keep iron in its non toxic form. Its synthesized by the bone marrow macrophages and hepatocytes.[] Thrombotic thrombocytopenic purpura: A rare blood disorder causing small blood clots to form in blood vessels throughout the body.[]

  • Leukoerythroblastic Anemia

    cells (echinocytes) may indicate: Uremia The presence of spur cells (acanthocytes) may indicate: Abetalipoproteinemia Severe liver disease The presence of teardrop-shaped[] Giant metamyelocytes were seen in all the bone marrow. The iron stores were reduced (Grade 0–1 ) in only one case and increased in seven cases.[] Although mimicking features of thrombotic thrombocytopenic purpura (TTP), subsequent bone marrow examination instead revealed an association with occult recurrence of necrotic[]

  • Gaisbock's Syndrome

    They may be artefactual - see Crenated cells - or pathological - see Burr cells above.[] marrow Panhyperplasia Erythroid hyperplasia N Iron stores N N Chromosome studies Abnormal (50%) N N LABORATORY DIFFERENTIAL OF POLYCYTHEMIA # Hb, # Hct, # RBC ABSOLUTE Red[] thrombocytopenic purpura 96 Hyperviscosity and stroke 100 Calcium hypercalcemia magnesium and brain ischemia 110 Cerebral vasoconstriction syndromes 114 Eclampsia and stroke[]

  • Posthemorrhagic Anaemia of the Newborn

    Other findings include burr cells (uremia), spherocytes (hereditary spherocytosis, autoimmune hemolysis, G6PD deficiency), elliptocytes (hereditary elliptocytosis), schistocytes[] […] most common type of normocytic anemia Anemia of Chronic Disease/Inflammation Pathophysiology - Increased accumulation of iron stores in macrophages - Decreased delivery of[] Thrombocytopenic Purpura and Atypical Hemolytic Uremic Syndrome Microangiopathy in Pregnancy.[]

  • Hypochromic Microcytic Anemia with Iron Overload Type 2

    Echinocytes (Burr Cells): resemble burrs Elliptocytes/Ovalocytes: elliptical or oval-shaped cells Keratocytes (Horn Cells): resemble horns Microspherocytes: smaller Macrocytes[] increased iron stores, ringed sideroblasts 15% of marrow erythroblasts, identify with iron stain on marrow smear, has nucleus completely or partially (at least one third[] Thrombocytopenic Purpura Trigger Finger (Digital Stenosing Tenosynovitis) Trochanteric Bursitis NEW ALGORITHMS INCLUDE Amenorrhea, Primary Amenorrhea, Secondary Back Pain[]

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