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21 Possible Causes for Bone Marrow with Increased Iron Stores, Congenital Nonspherocytic Hemolytic Anemia, Erythrocytes Decreased

  • Hereditary Spherocytosis

    Defects in these proteins lead to a loss in RBC membrane cohesion and membrane surface area, resulting in erythrocyte sphering, decreased deformability and premature destruction[orpha.net] Stability studies with blood from HS patients showed a significant decrease in hyperchromic erythrocytes after 6 h storage.[ncbi.nlm.nih.gov] […] encode the red blood cell (RBC) membrane proteins erythrocytic 1 spectrin alpha chain, erythrocytic 1 spectrin beta chain, ankyrin-1, band 3 anion transport protein, and erythrocyte[orpha.net]

  • Autoimmune Hemolytic Anemia

    Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[doi.org] In patients with Evans syndrome, the mechanism of destruction of erythrocytes is thought to be similar to AIHA.[cancertherapyadvisor.com] Premature destruction of erythrocytes occurs intravascularly or extravascularly. The etiologies of hemolysis often are categorized as acquired or hereditary.[aafp.org]

  • Congenital Hemolytic Anemia

    Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[ncbi.nlm.nih.gov] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org] Hemolytic Congenital, Nonspherocytic Anemia: Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there[medconditions.net]

  • Pyruvate Kinase Deficiency

    decreased erythrocyte pyruvate kinase (PK) activity.[ncbi.nlm.nih.gov] In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org] congenital nonspherocytic hemolytic anemia that has material basis in homozygous or compound heterozygous mutation in the PKLR gene on chromosome 1q22 pyruvate kinase deficiency[wikidata.org]

  • Acquired Toxic Hemolytic Anemia

    Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[oxfordmedicine.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] Szeinberg titration shortly a defect that the reduced be below normal. a decreased been disputed tile prior primaquine-sensitive is not ever, Beutler et al.’4 sensitive erythrocytes[studyres.com]

  • Congenital Heinz Body Hemolytic Anemia

    erythrocyte life span Double heterozygous sickling disorder Heinz bodies Hematopoietic maturation arrest Hemoglobin A1c above reference range Hemoglobin C disease Hemoglobin[icd9data.com] nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed, Scholar, Google, WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed, Scholar[lsd-project.jp] This suggests that the mutant protein in these variants is rendered unusually sensitive to proteolysis in the environment of the erythrocyte.[g6pd.org]

  • Congenital Dyserythropoietic Anemia

    Iron stores were increased although ring sideroblasts were absent.[ncbi.nlm.nih.gov] We also found that erythrocyte anion exchanger 1 protein is decreased in CDA-II homozygotes and obligate carriers alike.[ncbi.nlm.nih.gov] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[icd9data.com]

  • Hereditary Sideroblastic Anemia

    ; increase in iron store will need less transferrin, low TIBC).[forums.studentdoctor.net] […] and gama-interferon inhibit red cell production Shortened erythrocyte survival Autoimmune diseases may also cause antibody-mediated destruction CBC: Mild anemia (Hgb 9-11[quizlet.com] nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed, Scholar, Google, WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed, Scholar[lsd-project.jp]

  • Hexokinase Deficiency

    Ferritin, iron, and transferrin saturation are increased. Bone marrow shows hypercellularity with increased iron stores, increased sideroblasts, and ring sideroblasts.[web.archive.org] Glucose consumption of the hexokinase-deficient cells was not appreciably decreased, probably because less of the potent inhibitor glucose-6-phosphate was present in the erythrocytes[ncbi.nlm.nih.gov] The findings were entirely different from those of subsequently reported cases with congenital, nonspherocytic hemolytic anemia associated only with a specific deficiency[jamanetwork.com]

  • Acquired Hemolytic Anemia

    Assuming the bone marrow is normal and there are sufficient erythropoeitin and iron stores, acute anemia (ie. hemolysis or blood loss) should increase the retic % to 4-6%[errolozdalga.com] Premature destruction of red cells occurs through two primary mechanisms: (1) decreased erythrocyte deformability that leads to red-cell sequestration and extravascular haemolysis[oxfordmedicine.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com]

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