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19 Possible Causes for Bone Marrow with Increased Iron Stores, Congenital Nonspherocytic Hemolytic Anemia, Haptoglobin Decreased

  • Hereditary Spherocytosis

    Routine chemistry testing  Bilirubin: Increased  Indirect bilirubin  Urine urobilinogen: increased  Methaemalbumin: Increased  LDH: Increased  Haptoglobin: Decreased[slideshare.net] Other biochemical changes of hemolysis also are also present, including: increased lactate dehydrogenase (LDH) increased unconjugated bilirubin decreased serum haptoglobin[steadyhealth.com] Peripheral smear  ANISOCYTOSIS  Spherocyte  POIKILOCYTOSIS  Polychromatic cells  Target cells  Nucleated RBC can be present severe cases  Plt decreased if splenomegaly[slideshare.net]

  • Autoimmune Hemolytic Anemia

    , and haptoglobin decreased to less than 8 mg/dL.[ncbi.nlm.nih.gov] Haptoglobin: -Decreased with intravascular hemolysis. Urine analysis: -When hemolysis has been acute and brisk the patient may have hemoglobinuria.[oncologynurseadvisor.com] The ileus decreased with conservative treatment, however, autoimmune hemolytic anemia (AIHA) was diagnosed due to worsening anemia, a positive direct Coombs test, low haptoglobin[ncbi.nlm.nih.gov]

  • Pyruvate Kinase Deficiency

    In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org] PAGE BREAK Patients who achieved at least 1 g/dL increase in hemoglobin also demonstrated an increase in haptoglobin and decrease in lactate dehydrogenase in the first weeks[healio.com] congenital nonspherocytic hemolytic anemia that has material basis in homozygous or compound heterozygous mutation in the PKLR gene on chromosome 1q22 pyruvate kinase deficiency[wikidata.org]

  • Congenital Hemolytic Anemia

    This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org] Diagnosis is based on several laboratory parameters 1 : reticulocytosis increased unconjugated bilirubin increased lactate dehydrogenase decreased haptoglobin Pathology With[radiopaedia.org] Intravascular hemolysis is suggested by RBC fragments (schistocytes) on the peripheral smear and by decreased serum haptoglobin levels; however, haptoglobin levels can decrease[merckmanuals.com]

  • Acquired Toxic Hemolytic Anemia

    Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] The hemoglobin-haptoglobin complex travels to the liver for processing, thus decreasing the amount of free haptoglobin in the serum—an important laboratory finding when corroborating[accessmedicine.mhmedical.com] Intravascular hemolysis is suggested by RBC fragments (schistocytes) on the peripheral smear and by decreased serum haptoglobin levels; however, haptoglobin levels can decrease[msdmanuals.com]

  • Acquired Hemolytic Anemia

    Assuming the bone marrow is normal and there are sufficient erythropoeitin and iron stores, acute anemia (ie. hemolysis or blood loss) should increase the retic % to 4-6%[errolozdalga.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] -haptoglobin decreased - sign of intravascular hemolysis -bilirubin increased Immune-mediated acquired hemolytic anemia AUTOIMMUNE -will have positive DAT -AIHA ore common[brainscape.com]

  • Waters-West Syndrome

    Increased metabolic requirements, neoplasia. PATHOLOGY: Microcytic, hypochromic anemia. Low serum iron. Bone-Marrow will show absence of iron.[kumc.edu] MalaCards based summary : Hemolytic Anemia, Lethal Congenital Nonspherocytic, with Genital and Other Abnormalities, is also known as hemolytic anemia lethal congenital nonspherocytic[malacards.org] […] from baseline of at least 25%) [15] and evidence of microangiopathic hemolysis, which is characterized by elevated LDH levels, decreased haptoglobin, decreased hemoglobin[en.wikipedia.org]

  • Congenital Heinz Body Hemolytic Anemia

    nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed, Scholar, Google, WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed, Scholar[lsd-project.jp] Intravascular hemolysis is suggested by RBC fragments (schistocytes) on the peripheral smear and by decreased serum haptoglobin levels; however, haptoglobin levels can decrease[merckmanuals.com] Haptoglobin (intravascular haemolysis) Urine Haemoglobin Haemosiderin (useful in the diagnosis of intravascular haemolysis) Identify cause (history peripheral blood film[lifeinthefastlane.com]

  • Hexokinase Deficiency

    Ferritin, iron, and transferrin saturation are increased. Bone marrow shows hypercellularity with increased iron stores, increased sideroblasts, and ring sideroblasts.[web.archive.org] The findings were entirely different from those of subsequently reported cases with congenital, nonspherocytic hemolytic anemia associated only with a specific deficiency[jamanetwork.com] […] recessive inheritance ; Cholecystitis ; Cholelithiasis ; Congenital onset ; Hyperbilirubinemia ; Jaundice ; Nonspherocytic hemolytic anemia ; Normochromic anemia ; Normocytic[mousephenotype.org]

  • Red Blood Cell Disorder

    Ferritin: soluble iron binding storage protein also helps to keep iron in its non toxic form. Its synthesized by the bone marrow macrophages and hepatocytes.[slideplayer.com] Summary Epidemiology PK deficiency is the most frequent cause of congenital nonspherocytic hemolytic anemia with a prevalence estimated at 1/20,000 in the general white population[orpha.net] , as in patients with congenital nonspherocytic hemolytic anemia due to glucose-6-phosphate dehydrogenase or pyruvate kinase deficiency.[mayomedicallaboratories.com]