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17 Possible Causes for Bone Marrow with Increased Iron Stores, Congenital Nonspherocytic Hemolytic Anemia, Hematocrit Decreased

  • Hereditary Spherocytosis

    A complete blood count (CBC) may show increased reticulocytes, a sign of increased red blood cell production, and decreased hemoglobin and hematocrit.[en.wikipedia.org] Reticulocytes decreased to 0%. Spherocytosis was present on the peripheral blood smear.[bmcresnotes.biomedcentral.com] […] l (granulocytes, 35%; lymphocytes, 44%; atypical lymphocytes, 9%; and monocytes, 12%), red blood cell count was 1.68   10 12 /l; hemoglobin concentration was 5.4 g/dl; hematocrit[bmcresnotes.biomedcentral.com]

  • Autoimmune Hemolytic Anemia

    The differential white blood count shows a decrease in most types of cells but not lymphocytes .[labtestsonline.org] The differential white blood count shows a decrease in most types of cells but not lymphocytes.[labtestsonline.org] Hemoglobin and/or hematocrit may be low. RBC and WBC counts are low. Platelet count is low. Red blood cell indices are usually normal.[labtestsonline.org]

  • Congenital Hemolytic Anemia

    This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org] After partial splenectomy, children overall had decreased transfusion requirements, increased hematocrits, decreased bilirubin levels, decreased reticulocyte counts, and elimination[ncbi.nlm.nih.gov] Hemolytic Congenital, Nonspherocytic Anemia: Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there[medconditions.net]

  • Pyruvate Kinase Deficiency

    In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org] […] density of mature erythrocytes, increased hematocrit, as well as decreased iron overload in kidney and liver and decreased serum iron.[ncbi.nlm.nih.gov] congenital nonspherocytic hemolytic anemia that has material basis in homozygous or compound heterozygous mutation in the PKLR gene on chromosome 1q22 pyruvate kinase deficiency[wikidata.org]

  • Congenital Dyserythropoietic Anemia

    Iron stores were increased although ring sideroblasts were absent.[ncbi.nlm.nih.gov] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[icd9data.com] Following delivery the infant had serial blood counts performed over a 6-week period, which noted a steady decrease in her hematocrit to 16%.[bloodjournal.org]

  • Acquired Toxic Hemolytic Anemia

    Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] Hematocrit Decreased Confirm compensatory RBC production Reticulocyte count Increased Confirm hemolysis Peripheral smear Schistocytes—intravascular hemolysis, RBCs fragmented[accessmedicine.mhmedical.com] Anemia is an abnormal condition of the blood showed by low levels of hemoglobin, red blood cells, or hematocrit.[vapingdaily.com]

  • Waters-West Syndrome

    Increased metabolic requirements, neoplasia. PATHOLOGY: Microcytic, hypochromic anemia. Low serum iron. Bone-Marrow will show absence of iron.[kumc.edu] MalaCards based summary : Hemolytic Anemia, Lethal Congenital Nonspherocytic, with Genital and Other Abnormalities, is also known as hemolytic anemia lethal congenital nonspherocytic[malacards.org] If a sudden drop in hematocrit (Hct) occurs, therapeutic transfusion may be advisable.[emedicine.medscape.com]

  • Hexokinase Deficiency

    Ferritin, iron, and transferrin saturation are increased. Bone marrow shows hypercellularity with increased iron stores, increased sideroblasts, and ring sideroblasts.[web.archive.org] The findings were entirely different from those of subsequently reported cases with congenital, nonspherocytic hemolytic anemia associated only with a specific deficiency[jamanetwork.com] […] recessive inheritance ; Cholecystitis ; Cholelithiasis ; Congenital onset ; Hyperbilirubinemia ; Jaundice ; Nonspherocytic hemolytic anemia ; Normochromic anemia ; Normocytic[mousephenotype.org]

  • Acquired Hemolytic Anemia

    Assuming the bone marrow is normal and there are sufficient erythropoeitin and iron stores, acute anemia (ie. hemolysis or blood loss) should increase the retic % to 4-6%[errolozdalga.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] Patients usually have decreased hemoglobin concentration, hematocrit, and red blood cell count, but some can have compensated disorders, and symptoms such as reticulocytosis[mayomedicallaboratories.com]

  • Red Blood Cell Disorder

    Ferritin: soluble iron binding storage protein also helps to keep iron in its non toxic form. Its synthesized by the bone marrow macrophages and hepatocytes.[slideplayer.com] Summary Epidemiology PK deficiency is the most frequent cause of congenital nonspherocytic hemolytic anemia with a prevalence estimated at 1/20,000 in the general white population[orpha.net] The hematocrit of clients with sickle cell disease is usually low (between 20% and 30%).[intranet.tdmu.edu.ua]