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13 Possible Causes for Bone Marrow with Increased Iron Stores, Congenital Nonspherocytic Hemolytic Anemia, Osmotic Fragility Increased

  • Hereditary Spherocytosis

    fragility: increased; basis for diagnostic testing Diagrams / tables Images hosted on other servers: Scatter diagram of CBC Treatment Splenectomy (prolongs survival of red[] Blood film showed about 70% spherocytes, reticulocytosis of 6.5%, increased osmotic fragility test and a negative direct antiglobulin test.[] The evaluation of her mother revealed spherocytosis with anemia and increased osmotic fragility of RBCs.[]

  • Congenital Hemolytic Anemia

    This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[] Osmotic fragility of fresh blood was increased, and postsplenectomy blood showed a fraction of extremely fragile cells.[] The Type I cases showed the following features: normocytic or slightly macrocytic anemia with mild hypochromia and some stippling; a decreased or normal osmotic fragility[]

  • Autoimmune Hemolytic Anemia

    Autoimmune hemolytic anemia (AIHA) is a relatively uncommon disorder caused by autoantibodies directed against self red blood cells. It can be idiopathic or secondary, and classified as warm, cold (cold hemagglutinin disease (CAD) and paroxysmal cold hemoglobinuria) or mixed, according to the thermal range of the[…][]

  • Pyruvate Kinase Deficiency

    In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[] Partial PK deficiency was associated with decreased red cell ATP content and markedly increased osmotic fragility.[] congenital nonspherocytic hemolytic anemia that has material basis in homozygous or compound heterozygous mutation in the PKLR gene on chromosome 1q22 pyruvate kinase deficiency[]

  • Acquired Toxic Hemolytic Anemia

    Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[] […] incubated osmotic fragility Negative DAT Increased MCHC 36% due to relative cellular dehydration Increased bilirubin, LDH (may be subtle) 18 (Incubated) Osmotic Fragility[] Congenital Hemolytic Anemia is a general term for hemolytic anemia that is present from birth and in which the lifespan of red blood cells is diminished, such as occurs in[]

  • Waters-West Syndrome

    Increased metabolic requirements, neoplasia. PATHOLOGY: Microcytic, hypochromic anemia. Low serum iron. Bone-Marrow will show absence of iron.[] MalaCards based summary : Hemolytic Anemia, Lethal Congenital Nonspherocytic, with Genital and Other Abnormalities, is also known as hemolytic anemia lethal congenital nonspherocytic[] […] of the jaundice pigment bilirubin due to the breakup of the red cells) and increased osmotic fragility of the red cells.[]

  • Acquired Hemolytic Anemia

    Assuming the bone marrow is normal and there are sufficient erythropoeitin and iron stores, acute anemia (ie. hemolysis or blood loss) should increase the retic % to 4-6%[] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[] The tendency toward spherocytosis as measured by increased osmotic fragility may or may not be present in acquired hemolytic anemia.[]

  • Congenital Heinz Body Hemolytic Anemia

    nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed, Scholar, Google, WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed, Scholar[] osmotic fragility Heterozygous individuals are symptomless Unstable hemoglobin disorders Contain amino acid changes in internal portions of he hgb chains leading to decreased[] About […] Red Blood Cell Enzyme Deficiencies These conditions are sometimes called congenital nonspherocytic anemias.[]

  • Hexokinase Deficiency

    Ferritin, iron, and transferrin saturation are increased. Bone marrow shows hypercellularity with increased iron stores, increased sideroblasts, and ring sideroblasts.[] The findings were entirely different from those of subsequently reported cases with congenital, nonspherocytic hemolytic anemia associated only with a specific deficiency[] […] recessive inheritance ; Cholecystitis ; Cholelithiasis ; Congenital onset ; Hyperbilirubinemia ; Jaundice ; Nonspherocytic hemolytic anemia ; Normochromic anemia ; Normocytic[]

  • Red Blood Cell Disorder

    Ferritin: soluble iron binding storage protein also helps to keep iron in its non toxic form. Its synthesized by the bone marrow macrophages and hepatocytes.[] The shipping control specimen is required to adequately interpret these cases, as temperature extremes can increase fragility of the specimen.[] Summary Epidemiology PK deficiency is the most frequent cause of congenital nonspherocytic hemolytic anemia with a prevalence estimated at 1/20,000 in the general white population[]

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