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22 Possible Causes for Bone Marrow with Increased Iron Stores, Congenital Nonspherocytic Hemolytic Anemia, Reticulocytes Increased

  • Hereditary Spherocytosis

    Reticulocyte count: Increased Treatment: Splenectomy is indicated for moderate to severe cases, but not mild cases.[medical-labs.net] In all patients requiring secondary total splenectomy, increased reticulocyte levels within 2 years indicated hematologic recurrence.[ncbi.nlm.nih.gov] HS is associated with splenomegaly (commonly), anaemia (variably) with an increased reticulocyte count, and jaundice (occasionally).[bestpractice.bmj.com]

  • Autoimmune Hemolytic Anemia

    Over the course of the next 5 days, the Hb and Hct decreased to 4.1 g/dL and 12%, respectively, direct bili increased to 12.3 mg/day, reticulocytes slightly increased to 0.9%[ncbi.nlm.nih.gov] Laboratory data showed low hemoglobin levels and slightly increased reticulocyte counts, while direct and indirect antiglobulin tests were positive.[ncbi.nlm.nih.gov] Median absolute reticulocyte counts decreased from 236 to 109 x 10(9)/L (P .01).[ncbi.nlm.nih.gov]

  • Congenital Hemolytic Anemia

    After partial splenectomy, children overall had decreased transfusion requirements, increased hematocrits, decreased bilirubin levels, decreased reticulocyte counts, and elimination[ncbi.nlm.nih.gov] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org] As a result of splenectomy, reticulocyte counts often increase and transfusion needs are reduced.[orpha.net]

  • Pyruvate Kinase Deficiency

    Char10C mice also display a reduction in anemia phenotypes associated with the PklrG338D mutation including decreased splenomegaly, decreased circulating reticulocytes, increased[ncbi.nlm.nih.gov] In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org] As a result of splenectomy, reticulocyte counts often increase and transfusion needs are reduced.[orpha.net]

  • Acquired Toxic Hemolytic Anemia

    The complete blood count (CBC) serves as the diagnostic cornerstone, providing the anemic level hemoglobin and hematocrit and the increased reticulocyte count indicative of[accessmedicine.mhmedical.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] […] in the Erythropoietin Secretion : increases reticulocyte percentage (and absolute reticulocyte count) - increases RBC production Reticulocytosis is Found in Most Patients[mdnxs.com]

  • Congenital Dyserythropoietic Anemia

    Iron stores were increased although ring sideroblasts were absent.[ncbi.nlm.nih.gov] On this treatment, hemoglobin and reticulocytes increased and transfusions became unnecessary.[ncbi.nlm.nih.gov] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[icd9data.com]

  • Waters-West Syndrome

    Increased metabolic requirements, neoplasia. PATHOLOGY: Microcytic, hypochromic anemia. Low serum iron. Bone-Marrow will show absence of iron.[kumc.edu] Laboratory studies show evidence not only of many spherocytes but also increased numbers of reticulocytes (young red blood cells), hyperbilirubinemia (increased blood levels[medicinenet.com] MalaCards based summary : Hemolytic Anemia, Lethal Congenital Nonspherocytic, with Genital and Other Abnormalities, is also known as hemolytic anemia lethal congenital nonspherocytic[malacards.org]

  • Acquired Hemolytic Anemia

    Assuming the bone marrow is normal and there are sufficient erythropoeitin and iron stores, acute anemia (ie. hemolysis or blood loss) should increase the retic % to 4-6%[errolozdalga.com] -hb and Hct decreased -reticulocyte increased -peripheral smear - schistocytes from shearing force, spherocytes from extravascular hemolysis -LDH - elevated -K may be elevated[brainscape.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com]

  • Congenital Heinz Body Hemolytic Anemia

    The reticulocyte count may be increased. Splenomegaly and Heinz bodies may also be present.[mayomedicallaboratories.com] nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed, Scholar, Google, WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed, Scholar[lsd-project.jp] Examination New onset of pallor and anemia Jaundice Gallstones Splenomegaly /- hepatomegaly INVESTIGATIONS Confirm haemolysis Increased absolute reticulocyte count LDH (elevation[lifeinthefastlane.com]

  • Congenital Dyserythropoietic Anemia Type 1

    Prussian blue staining (Perl’s reaction) on aspirated bone marrow particles, revealed iron stores to be normal to increased.[indianpediatrics.net] On this treatment, hemoglobin and reticulocytes increased and transfusions became unnecessary.[ncbi.nlm.nih.gov] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[icd9data.com]

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