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11 Possible Causes for Bone Marrow with Increased Iron Stores, Congenital Nonspherocytic Hemolytic Anemia, Scleral Icterus

  • Autoimmune Hemolytic Anemia

    Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale.[ncbi.nlm.nih.gov] His physical examination was remarkable for scleral icterus, shifting dullness, hepatosplenomegaly and bilateral lower-extremity pitting edema.[jmedicalcasereports.com]

  • Pyruvate Kinase Deficiency

    In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org] icterus (yellow coloring of the whites of the eyes) Abdominal pain Enlarged spleen (splenomegaly) Gallstones How is PK deficiency diagnosed?[agios.com] congenital nonspherocytic hemolytic anemia that has material basis in homozygous or compound heterozygous mutation in the PKLR gene on chromosome 1q22 pyruvate kinase deficiency[wikidata.org]

  • Hereditary Spherocytosis

    Scleral icterus in their 4-year-old sibling and in their mother led to the diagnosis of HS in them as well.[ncbi.nlm.nih.gov] Physical examination should seek signs such as scleral icterus, jaundice, and splenomegaly. Are you sure your patient has hereditary spherocytosis?[clinicaladvisor.com]

  • Congenital Hemolytic Anemia

    This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org] Scleral icterus and/or jaundice may occur, and the spleen may enlarge.[merckmanuals.com] Hemolytic Congenital, Nonspherocytic Anemia: Any one of a group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there[medconditions.net]

  • Acquired Toxic Hemolytic Anemia

    Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] Scleral icterus and/or jaundice may occur, and the spleen may enlarge.[msdmanuals.com] Also check for jaundice, or scleral icterus. Cervical, axillary and inguinal lymphadenopathy may be present.[clinicaladvisor.com]

  • Red Blood Cell Disorder

    Ferritin: soluble iron binding storage protein also helps to keep iron in its non toxic form. Its synthesized by the bone marrow macrophages and hepatocytes.[slideplayer.com] Summary Epidemiology PK deficiency is the most frequent cause of congenital nonspherocytic hemolytic anemia with a prevalence estimated at 1/20,000 in the general white population[orpha.net] icterus (yellow eyes) Enlarged spleen Gallstones RBC disorders may be suspected based on the general findings of a complete medical history and physical exam.[danafarberbostonchildrens.org]

  • Congenital Heinz Body Hemolytic Anemia

    nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed, Scholar, Google, WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed, Scholar[lsd-project.jp] Scleral icterus and/or jaundice may occur, and the spleen may enlarge.[merckmanuals.com] Drug-induced hemolysis can be severe, involving the sudden onset of pallor, malaise, scleral icterus, dark urine, and abdominal or back pain.[obgynkey.com]

  • Congenital Dyserythropoietic Anemia Type 3

    Prussian blue staining (Perl’s reaction) on aspirated bone marrow particles, revealed iron stores to be normal to increased.[indianpediatrics.net] , as an aid in searching Hereditary nonspherocytic hemolytic anemia Congenital hemolytic anemia Adenlyate kinase deficiency AK AK1 ALDOA Aldolase A deficiency ALDOA deficiency[mayomedicallaboratories.com] Our patient had scleral icterus at presentation, but no organomegaly was identified.[link.springer.com]

  • Congenital Dyserythropoietic Anemia Type 2

    Prussian blue staining (Perl’s reaction) on aspirated bone marrow particles, revealed iron stores to be normal to increased.[indianpediatrics.net] , type I Congenital dyserythropoietic anemia, type II Congenital dyserythropoietic anemia, type III Congenital nonspherocytic hemolytic anemia due to inborn error of metabolism[icd9data.com] Our patient had scleral icterus at presentation, but no organomegaly was identified.[link.springer.com]

  • Acute Hemolytic Anemia

    Assuming the bone marrow is normal and there are sufficient erythropoeitin and iron stores, acute anemia (ie. hemolysis or blood loss) should increase the retic % to 4-6%[errolozdalga.com] nonspherocytic hemolytic anemia * (n) 先天性貧血 P614 ** せんてんせいひんけつ PubMed, Scholar, Google, WikiPedia congenital anemia * (n*) 先天性溶血性貧血 *** せんてんせいようけつせいひんけつ シソーラス PubMed, Scholar[lsd-project.jp] Examination revealed scleral icterus with pale conjunctivae and a mildly tender upper abdomen. He was jaundiced but did not have hepatosplenomegaly.[epmonthly.com]