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42 Possible Causes for Bone Marrow with Increased Iron Stores, Mean Corpuscular Volume Increased

  • Pernicious Anemia

    Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[orpha.net] […] in mean corpuscular volume and levels of ferritin and gastrin, and a decrease in vitamin B 12 levels.[doi.org] Average size of RBCs (mean corpuscular volume, MCV)—decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean[labtestsonline.org]

  • Aplastic Anemia

    Average size of RBCs (mean corpuscular volume, MCV)—decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean[labtestsonline.org] The reader is referred to general references for a complete list of diseases that can present with various degrees of cytopenias. 4 An elevated mean corpuscular volume is[doi.org] […] corpuscular hemoglobin concentration, MCHC)—decreased Increased variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller[labtestsonline.org]

  • Megaloblastic Anemia

    Catabolism of hemoglobin by the reticuloendothelial cells of the marrow and liver accounts for the increased iron stores and the bilirubinemias [7].[path.upmc.edu] Physicians caring for patients who receive low-dose methotrexate should be aware that an increase in the erythrocyte mean corpuscular volume may be a useful indicator of folate[ncbi.nlm.nih.gov] The blood film can point towards vitamin deficiency: Decreased red blood cell (RBC) count and hemoglobin levels Increased mean corpuscular volume (MCV, 100 fL) and mean corpuscular[en.wikipedia.org]

  • Autoimmune Hemolytic Anemia

    Reticulocyte counts are usually elevated, and an increased MCV (mean corpuscular volume) (greater than 100 fl) can be seen, due to the larger size of reticulocytes in comparison[cancertherapyadvisor.com] At 2 to 4 weeks after diagnosis, acute anemia, characterized by an elevated mean corpuscular volume (MCV), reticulocytosis, an undetectable haptoglobin level, and an increased[nejm.org] Average size of RBCs (mean corpuscular volume, MCV)—decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean[labtestsonline.org]

  • Folate-Deficiency Anemia

    The mean corpuscular volume is typically increased (above 96 fL ).[symptoma.com] Folate Deficiency causes a specific type of Anemia called Macrocytic/Megaloblstic Anemia where the size (Mean Corpuscular Volume) of the red blood cells increased .[stomponstep1.com] In a recent study, 7 percent of patients had a mean corpuscular volume greater than 96 fL, and 1.7 percent had a mean corpuscular volume greater than 100 fL. 2 With the advent[aafp.org]

  • Congenital Hemolytic Anemia

    Mean corpuscular hemoglobin concentration (MCHC) is increased (35-38%) in approximately 50% of patients.[clinicaladvisor.com] Mean corpuscular volume (MCV) is usually normal except in cases of severe HS when the MCV may be mildly decreased.[clinicaladvisor.com]

  • Hereditary Spherocytosis

    […] count 19%, mean sphered corpuscular volume 71.66 fl, total bilirubin 57.60 μmol/l, and blood smears showed increased spherocytosis.[ncbi.nlm.nih.gov] In hereditary spherocytosis, because RBCs are spheroidal and the mean corpuscular volume (MCV) is normal, the mean corpuscular diameter is below normal, and RBCs resemble[merckmanuals.com] The mean corpuscular volume is usually normal, but mean corpuscular hemoglobin concentration is often increased. The reticulocyte count is often increased.[mjdrdypu.org]

  • Leukoerythroblastic Anemia

    Giant metamyelocytes were seen in all the bone marrow. The iron stores were reduced (Grade 0–1 ) in only one case and increased in seven cases.[jahjournal.org] mean corpuscular volume (macrocytic anemia: MCV 100 fL) Ethanol abuse Folate deficiency Vitamin B12 deficiency Myelodysplastic syndromes Acute myeloid leukemias (eg, erythroleukemia[timeofcare.com] Only eight patients gave consent for bone marrow aspiration. All marrows were hypercellular, showing erythroid hyperplasia with megaloblastic erythropoiesis (100%).[jahjournal.org]

  • Megaloblastic Anaemia in Pregnancy

    Bone marrow aspiration findings were suggestive of megaloblastic anemia with increased iron stores, without the presence of any granuloma or parasite ( Fig . 2 ). o n further[thejh.org] In a recent study, 7 percent of patients had a mean corpuscular volume greater than 96 fL, and 1.7 percent had a mean corpuscular volume greater than 100 fL. 2 With the advent[aafp.org] Routine Blood Count: MCV or Mean Corpuscular Volume is raised in this disease, that is, the cell size is increased.[medindia.net]

  • Congenital Dyserythropoietic Anemia

    Iron stores were increased although ring sideroblasts were absent.[ncbi.nlm.nih.gov] Bone marrow examination revealed marked normoblastic erythroid hyperplasia with dyserythropoiesis (36%) and the presence of bi- and multinucleated erythroblasts with equal-sized[ncbi.nlm.nih.gov]

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