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34 Possible Causes for Bone Marrow with Increased Iron Stores, Red Blood Cell Distribution Width Increased

  • Megaloblastic Anemia

    Catabolism of hemoglobin by the reticuloendothelial cells of the marrow and liver accounts for the increased iron stores and the bilirubinemias [7].[path.upmc.edu] […] variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis[labtestsonline.org] Bone marrow aspiration is done to rule out a primary bone marrow disorder such as a myelodysplastic syndrome or leukemia and assess iron stores.[symptoma.com]

  • Sickle Cell Disease

    Delayed hemolytic transfusion reaction (DHTR) is a life-threatening complication in patients with sickle cell disease, characterized by difficulties in diagnosis and management. Certain reports have suggested successful salvage treatment with the terminal complement inhibitor, eculizumab. We here report evidence of[…][ncbi.nlm.nih.gov]

  • Folate-Deficiency Anemia

    Folate-deficiency anemia frequently appears in women of childbearing age, in those who are pregnant or lactating, in alcohol abusers and malnourished individuals, thus proving the necessity of folate oral supplementation. Prevention must be carefully conducted, since the elderly may have difficulties tolerating folate[…][symptoma.com]

  • Iron Deficiency

    Iron deficiency Iron deficiency develops in stages. In the first stage, iron requirement exceeds intake, causing progressive depletion of bone marrow iron stores.[merckmanuals.com] Average size of RBCs (MCV) — may be decreased Average amount of Hb in RBCs (MCH) — may be decreased Increased variation in the size of RBCs (red cell distribution width (RDW[labtestsonline.org.au] This is reflected in the red blood cell distribution width (RDW); thus, the earliest evidence of the development of an iron-deficient erythropoiesis is seen in the peripheral[emedicine.com]

  • Iron Deficiency Anemia

    Because iron is stored in the bone marrow, this test can provide a good idea of how much iron is in the body. But bone marrow aspirations are not done very often.[cham.org] […] high red blood cell distribution width, reflecting an increased variability in the size of red blood cells.A low mean corpuscular volume also appears during the course of[en.wikipedia.org] This is reflected in the red blood cell distribution width (RDW); thus, the earliest evidence of the development of an iron-deficient erythropoiesis is seen in the peripheral[emedicine.medscape.com]

  • Myelodysplasia

    marrow: (general MDS findings): Usually hypercellular or normocellular, 10% are hypocellular; iron stores often increased Disordered (dysplastic) differentiation affecting[pathologyoutlines.com] […] myeloblasts Platelets : thrombocytopenia, giant platelets Note: In severely cytopenic patients, buffy coat smears of peripheral blood can be used to perform differential Bone[pathologyoutlines.com]

  • Hereditary Spherocytosis

    FBC shows raised MCHC and increased red cell distribution width.[patient.info] FBC and blood film including reticulocyte count. Spherocytes and reticulocytosis are seen on peripheral blood film.[patient.info] […] on the basis of a family history, typical clinical features and laboratory investigations - spherocytes, raised mean corpuscular haemoglobin concentration (MCHC), and an increase[patient.info]

  • Pernicious Anemia

    […] variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis[labtestsonline.org] […] decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean corpuscular hemoglobin concentration, MCHC)—decreased Increased[labtestsonline.org]

  • Anemia of Infection

    […] variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis[labtestsonline.org] […] decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean corpuscular hemoglobin concentration, MCHC)—decreased Increased[labtestsonline.org]

  • Aplastic Anemia

    […] variation in the size of RBCs (red cell distribution width, RDW) A blood smear may reveal RBCs that are smaller and paler than normal as well as RBCs that vary in size (anisocytosis[labtestsonline.org] […] decreased Average amount of hemoglobin in RBCs (mean corpuscular hemoglobin, MCH)—decreased Hemoglobin concentration (mean corpuscular hemoglobin concentration, MCHC)—decreased Increased[labtestsonline.org]

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