Bone Marrow with Ringed Sideroblasts: Causes & Reasons

Possible Causes for Bone Marrow with Ringed Sideroblasts

The ICD code D640 is used to code Sideroblastic anemia Sideroblastic anemia or sideroachrestic anemia is a form of anemia in which the bone marrow produces ringed sideroblasts [icd.codes]

Abstract Sideroblastic anemia is characterized by anemia with the emergence of ring sideroblasts in the bone marrow. [ncbi.nlm.nih.gov]

Ringed sideroblasts are seen in the bone marrow. 2. The anemia is moderate to severe 3. [slideshare.net]

Sideroblastic Anemia

Forty-six percent of erythroblasts in the bone marrow were ringed sideroblasts. Laboratory findings showed an IgG-kappa monoclonal gammopathy. [ncbi.nlm.nih.gov]

(C) Bone marrow smear stained by Perls’ reaction showing several ring sideroblasts. MGG x1,250. (D) Bone marrow smear. [haematologica.org]

Complete blood count (CBC): microcytic anemia, Bone marrow biopsy : ringed sideroblasts seen on blood smears. [stepwards.com]

Acquired Sideroblastic Anemia

marrow shows the classic ringed sideroblasts not seen in normal bone marrow tissue.The ringed sideroblasts represent iron storage in the mitochondria of normoblasts. [encyclopedia.lubopitko-bg.com]

sideroblasts are seen in the bone marrow. [en.wikipedia.org]

Analysis of the peripheral blood revealed pancytopenia, and the bone marrow findings showed marked ringed sideroblasts and chromosomal deletion (46XY, 11q-). [ncbi.nlm.nih.gov]

Refractory Anemia with Excess Blasts in Transformation

marrow less than 5 percent blasts in the bone marrow 15 percent or more ringed sideroblasts or 5 percent or more ringed sideroblasts in the presence of an SF3B1 mutation [mskcc.org]

[…] percentages of blood and bone marrow blasts as in refractory anemia Ringed sideroblasts accounting for more than 15 percent of all nucleated cells in the bone marrow Refractory [medicalcriteria.com]

marrow and pathological abnormalities primarily seen in red cell precursors refractory anemia with ring sideroblasts (RARS) less than 5% myeloblasts in the bone marrow, but [radiopaedia.org]

Refractory Anemia

[…] by isolated erythroid dysplasia and 15% or more bone marrow ring sideroblasts. [molecularmedicine.unipv.it]

Refractory anemia with ring sideroblasts (RARS) is a subtype of myelodysplastic syndrome (MDS) characterized by 15% or more ring sideroblasts in the bone marrow according [ncbi.nlm.nih.gov]

where data was available on the exact percentage of bone marrow ring sideroblasts, have been divided in three groups by percentage of bone marrow ring sideroblasts (0–14% [journals.plos.org]

Refractory Anemia with Excess Blasts

marrow less than 5 percent blasts in the bone marrow 15 percent or more ringed sideroblasts or 5 percent or more ringed sideroblasts in the presence of an SF3B1 mutation [mskcc.org]

Refractory cytopenia with multilineage dysplasia and ring sideroblasts (RCMD-RS) is a subcategory characterized by more than 15% of erythroid precursors in the bone marrow [businessandleadership.com]

Refractory Anemia with Ringed Sideroblasts (RARS) Peripheral Blood Anemia No blasts Bone Marrow Erythroid dysplasia only 15 percent ringed sideroblasts Refractory Cytopenia [caprockhematology.com]

Idiopathic Refractory Anemia

sideroblasts are seen in the bone marrow. [en.wikipedia.org]

Hypochromic Microcytic Anemia with Iron Overload Type 2

Ringed sideroblasts are seen in the bone marrow. [ipfs.io]

sideroblasts are seen in the bone marrow. [en.wikipedia.org]

and the presence of bone marrow ringed sideroblasts. [genecards.org]

Myelodysplasia

A test performed on bone marrow cells collected at a bone marrow examination Ring sideroblasts. Cells seen on a bone marrow examination Dysplasia. [boweniconcancercentre.co.nz]

marrow.1 Refractory cytopenia with multilineage dysphasia and ringed sideroblasts (RCMDRS) – Similar to RCMD, except the red blood cells contain iron ring deposits around [iconcancercentre.com.au]

Autosomal Dominant Aplasia and Myelodysplasia

[…] for Refractory Anaemia + Ringed Sideroblasts (RA + RS) Blood: Anaemia, no blasts Bone Marrow: Erythroid dysplasia with >15% ringed sideroblasts Blood and Bone Marrow features [brainscape.com]

sideroblasts (MDS-RS) – Anemia, no blasts; in bone marrow, ≥ 15% of erythroid precursors with ring sideroblasts or ≥ 5% ring sideroblasts if SF3B1 mutation is present MDS [emedicine.medscape.com]

marrow (20-29%) or blasts in the blood; Auer rods; absence of ringed sideroblasts; abnormal localization or immature granulocyte precursors in bone marrow section; completely [en.wikipedia.org]

Hypocupremia

We propose that copper deficiency plays role in causing dysplastic changes in bone marrow and increase in ringed sideroblasts. [bloodjournal.org]

[…] and ring sideroblasts. [doi.org]

In comparison, our patient's bone marrow had numerous myeloid and erythroid precursors with cytoplasmic vacuolization, but lacked ringed sideroblasts. [ncbi.nlm.nih.gov]

X-Linked Pyridoxine-Refractory Sideroblastic Anemia Type 1

[…] mitochondrial membrane protein, impairs mitochondrial respiration[9]), cycloserine, and linezolid.[11] Diagnosis Bone marrow aspirate: ring sideroblasts Ringed sideroblasts [scientiait.com]

Bone marrow shows erythroid hyperplasia with a maturation arrest.In excess of 40% of the developing erythrocytes are ringed sideroblasts. [scientiait.com]

[…] are seen in the bone marrow. [scientiait.com]

Autosomal Dominant Sideroblastic Anemia

and the presence of bone marrow ringed sideroblasts. [genecards.org]

sideroblasts are seen in the bone marrow. [en.wikipedia.org]

marrow ring sideroblasts. [scinapse.io]

Autosomal-Recessive Pyridoxine-Refractory Sideroblastic Anemia

Bone marrow shows erythroid hyperplasia with a maturation arrest.In excess of 40% of the developing erythrocytes are ringed sideroblasts. [scientiait.com]

[…] are seen in the bone marrow. [scientiait.com]

X-Linked Sideroblastic Anemia and Ataxia

sideroblasts are seen in the bone marrow. [en.wikipedia.org]

The iron-loaded erythroblasts, which are present in bone marrow, are called ring sideroblasts. [icdlist.com]

[…] cases, where data was available on the exact percentage of bone marrow ring sideroblasts, have been divided in three groups by percentage of bone marrow ring sideroblasts [journals.plos.org]

Thiamine-Responsive Megaloblastic Anemia - Diabetes Mellitus - Sensorineural Deafness

The combination of megaloblastic finding and ringed sideroblasts at bone marrow characterizes thiamine responsive megaloblastic anemia. [latunisiemedicale.com]

The bone marrow aspirate showed normal cellularity but abnormal erythropoiesis with megaloblastic and dyserythropoietic changes, ringed sideroblasts up to 50%. [latunisiemedicale.com]

Some patients exhibited severe pancytopenia with bone marrow dysplasic changes [4]. [latunisiemedicale.com]

Myopathy with Lactic Acidosis and Sideroblastic Anemia Type 2

sideroblasts are seen in the bone marrow. [en.wikipedia.org]

[…] is characterized by anemia with the emergence of ring sideroblasts in the bone marrow. [link.springer.com]

(C) Bone marrow smear stained by Perls’ reaction shows several ring sideroblasts. (D) Bone marrow smear – mitochondrial ferritin in granules surrounding the nucleus. [clinicaladvisor.com]

Thiamine-Responsive Megaloblastic Anemia

The combination of megaloblastic finding and ringed sideroblasts at bone marrow characterizes thiamine responsive megaloblastic anemia. [latunisiemedicale.com]

The bone marrow aspirate showed normal cellularity but abnormal erythropoiesis with megaloblastic and dyserythropoietic changes, ringed sideroblasts up to 50%. [latunisiemedicale.com]

Some patients exhibited severe pancytopenia with bone marrow dysplasic changes [4]. [latunisiemedicale.com]

SIFD Syndrome

[…] and presence of ring sideroblasts in the bone marrow. [unboundmedicine.com]

Iron stain demonstrated numerous ring sideroblasts (panel D; original magnification ×1000). [imagebank.hematology.org]

When Ring Sideroblasts on Bone Marrow Smears Are Inconsistent with the Diagnosis of Myelodysplastic Neoplasms. Girard S, Genevieve F, Rault E, Fenneteau O, Lesesve JF. [pubmed.ncbi.nlm.nih.gov]

X-Linked Erythropoietic Protoporphyria

and the presence of bone marrow ringed sideroblasts. [genecards.org]

[provided by RefSeq, Jul 2008] UniProt Comments for ALAS2 ALAS2: Defects in ALAS2 are a cause of anemia sideroblastic X- linked (XLSA). [mybiosource.com]

Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis [genecards.org]

Dimorphic Anemia

Sideroblastic anemia- elevated serum iron and transferrin with ringed sideroblasts in the bone marrow MCV (90-100fl) Renal failure: BUN/Creatinine Aplastic anemia- ask for [ncbi.nlm.nih.gov]

sideroblasts in bone marrow, elevated lead levels AOCD- may be normocytic Thalassemia- RBC count may be normal/high, low MCV, target cells, and basophilic stippling are on [ncbi.nlm.nih.gov]

[…] with increased total iron-binding capacity (TIBC), transferrin levels, and soluble transferrin receptor Lead poisoning- basophilic stippling on the peripheral blood smear, ringed [ncbi.nlm.nih.gov]

Refractory Megaloblastic Anemia

marrow erythroid lineage abnormalties Ring sideroblasts ≥5 iron granules encircling ≥1/3 of the nucleus Must involve ≥15% of erythroids to make the diagnosis of RARS Usually [surgpathcriteria.stanford.edu]

Examination of the bone marrow reveals megaloblastic anemia with erythroblasts often containing iron filled mitochondria (ringed sideroblasts). [7], [8], [9] SLC19A2, which [ijem.in]

sideroblasts (see definition below) Must involve ≥15% of total erythroid precursors Sustained platelet elevation ≥450 x 10 3 /μL Bone marrow biopsy with megakaryocytic hyperplasia [surgpathcriteria.stanford.edu]

Myelodysplastic Syndrome due to 5q Deletion

Among most patients with an excess of bone marrow myeloblasts or ringed sideroblasts, the number of these cells returned to normal. [healio.com]

Refractory anaemia with ring sideroblasts (WHO)………  Bone marrow shows erythroid hyperplasia.  Myeloblasts are 41. [slideshare.net]

Bone marrow morphologic features returned to normal in 36% of patients who could be evaluated. [nejm.org]

Pearson Syndrome

Bone marrow aspiration reveals ring sideroblasts or vacuolization of bone marrow precursor cells. [frontiersin.org]

(Transmission electron microscopy; original 10,000x) Ringed sideroblast in the bone marrow (iron stain). [emedicine.medscape.com]

There were about 30% ring sideroblasts observed on perl's stain. [bloodjournal.org]

Microcytic Anemia

Diagnostic test – Prussian blue staining of bone marrow will show ringed sideroblasts Treatment Treat underlying cause Transfuse as necessary Key Terms Iron deficiency is [physicianassistantexamreview.com]

[…] anemia, thalassemias, myelodysplastic syndromes Bone marrow biopsy with ringed sideroblasts: sideroblastic anemia Normal iron studies: workup for acute blood loss, hemolytic [amboss.com]

Numerous ringed sideroblasts that exhibited pathognomonic ultrastructural features were seen in the bone marrow aspirate. [archivesofpathology.org]

Anemia due to Vitamin B6 Deficiency

sideroblasts are seen in the bone marrow. [en.wikipedia.org]

Sideroblastic anemia or sideroachrestic anemia is a form of anemia in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes) [en.wikipedia.org]

Bone marrow shows erythroid hyperplasia with a maturation arrest. In excess of 40% of the developing erythrocytes are ringed sideroblasts. [en.wikipedia.org]

Diamond-Blackfan Anemia Type 1

Prussian blue stain (for iron) of bone marrow aspirate, showing a ringed sideroblast (arrow) (right; ×100 oil-immersion objective). [ashpublications.org]

On retrospective bone marrow examination, all patients had erythroid hypoplasia and vacuolated progenitors, but ringed sideroblasts were present or reported in only 2 patients [ashpublications.org]

Alpha-Thalassemia - Myelodysplasia Syndrome

[…] pathologic ring sideroblasts), and G-banded karyotyping (abnormal in 50% of cases, including >80% of the patients with secondary MDS). [oncologynurseadvisor.com]

Autosomal Recessive Deafness 38

The bone marrow aspirate usually shows a megaloblastic bone marrow, dyserythropoietic changes and many ringed sideroblasts. [doctiktak.com]

The bone marrow aspirate usually shows megaloblastic changes and ringed sideroblasts. However, tri-lineage myelodysplasia has never been reported. [doctiktak.com]

The ringed sideroblasts reported in the bone marrow of some, but not all, cases may be due to a deficiency of a-ketoglutarate dehydrogenase, which is required for haem synthesis [doctiktak.com]

Autosomal Recessive Deafness 88

The bone marrow aspirate usually shows a megaloblastic bone marrow, dyserythropoietic changes and many ringed sideroblasts. [doctiktak.com]

The bone marrow aspirate usually shows megaloblastic changes and ringed sideroblasts. However, tri-lineage myelodysplasia has never been reported. [doctiktak.com]