Bone Marrow with Sea-Blue Histiocytes: Causes & Reasons

Possible Causes for Bone Marrow with Sea-Blue Histiocytes

Lipid analysis of isolated glomeruli show marked increase in the amount of free cholesterol and phospholipids. [15] Sea blue histiocytes on Wright-Giemsa are observed in bone [wikidoc.org]

marrow and spleen. [19] Epidemiology and Demographics The prevalence of Familial LCAT deficiency rare and is estimated to be less than 1/1,000,000. [wikidoc.org]

Sea-blue histiocytosis

Aspirated bone marrows contained sea-blue histiocytes, and nitroblue tetrazolium test was abnormal. [ncbi.nlm.nih.gov]

Sea Blue Histiocytes are large lipid-containing histiocytes in the bone marrow which stain sea blue in color. [askhematologist.com]

Sea-blue histiocytes and Gaucher cells in bone marrow of patients with chronic myeloid leukaemia. J Clin Pathol. 1988; 41: 960-962. [meducator3.net]

Niemann-Pick Disease Type B

[…] in several organs as lung, liver, spleen, kidney. microvacuolated hepatocytes (hepatic microsteatosis) large vacuolated foam cells (’NP cells’) on bone marrow biopsy sea [humpath.com]

Although pseudo-Gaucher cells and sea blue histiocytes can be found in bone marrow that is rapidly turning over, the combination of both numerous foam cells and sea blue histiocytes [imagebank.hematology.org]

Diagnosis was guided by the morphological finding in bone marrow smears of foamy and sea-blue histiocytes and confirmed by the measurement of acid lysosomal sphingomyelinase [ncbi.nlm.nih.gov]

Niemann-Pick Disease Type C

CONCLUSION: Although filipin staining should be used to confirm the diagnosis, bone marrow sea-blue histiocytes often help to diagnosis of NP-C. [ncbi.nlm.nih.gov]

After bone marrow biopsy showed characteristic sea-blue histiocytes, Niemann-Pick disease was suspected and confirmed by filipin stain of cultured fibroblasts. [ncbi.nlm.nih.gov]

Bone marrow biopsy demonstrated scattered sea blue histiocytes. Skin fibroblast testing showed 26% cholesterol esterification and indeterminate filipin staining. [jnnp.bmj.com]

Niemann-Pick Disease Type D

[…] in several organs as lung, liver, spleen, kidney. microvacuolated hepatocytes (hepatic microsteatosis) large vacuolated foam cells (’NP cells’) on bone marrow biopsy sea [humpath.com]

Sea blue histiocytes may be present in small numbers in normal bone marrow. [pathopedia-india.com]

Bone marrow examination showed characteristic lipid laden foamy histiocytes termed as niemann pick cells and sea blue histiocytes. [msjonline.org]

Niemann-Pick Disease

Foam cells were present in the bone marrow aspirate too, that contained also sea-blue histiocytes. [ncbi.nlm.nih.gov]

Bone marrow biopsy demonstrated scattered sea blue histiocytes. Skin fibroblast testing showed 26% cholesterol esterification and indeterminate filipin staining. [jnnp.bmj.com]

sea blue histiocytes/foamy macrophages or diagnosis was established by cholesterol esterification technique, filipin staining, mutational analysis of the NPC gene, or confirmed [jnnp.bmj.com]

Cholesterol Ester Storage Disease

Bone marrow cytology showed few, but clearly distinguishable, ‘sea-blue histiocytes’ and vacuolated macrophages, indicators of, among others, a lysosomal storage disease [njmonline.nl]

An adult patient is described with hepatomegaly and sea-blue histiocytes in the bone marrow. [ncbi.nlm.nih.gov]

In case 2, the combination of bone marrow cytology (‘sea-blue histiocytes’ and vacuolated macrophages), liver histology (microvesicular steatosis, bridging fibrosis and lipid [njmonline.nl]

GM1 Gangliosidosis Type 2

Bone marrow biopsies revealed sea-blue histiocytes while lysosomal enzyme assays showed normal glucosidase, hexosaminidase and neuraminidase activity but deficient ß-galactosidase [cags.org.ae]

Niemann-Pick Disease Type C2

[…] foam cells Sea-blue histiocyte syndrome Splenomegaly Abnormality of the musculoskeletal system Hypotonia Abnormality of the nervous system Cataplexy Cerebellar ataxia Dementia [ncbi.nlm.nih.gov]

marrow transplantation Enzyme replacement Micro description : Large macrophages with foamy cytoplasm Also sea blue histiocytes ( Ann Hematol 2001;80:620 ) Molecular description [pathologyoutlines.com]

marrow biopsy specimens revealing accumulation of lipid-filled macrophages (sea-blue histiocytes)-are definitive for the diagnosis. 8 In the present study, we analyzed HRCT [scielo.br]

Cataract - Ataxia - Deafness

Dx by finding "Sea Blue" histiocytes in bone marrow, supranuclear gaze palsy (upgaze). Vacuolated Lymphocytes, Sphingomyelinase def. [cmdg.org]

The diagnosis is based on the triad of vertical gaze paresis, organomegaly and foam cells (sea blue histiocytes) in the bone marrow. [neuroweb.us]

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]

Cerebellar Ataxia with Peripheral Neuropathy Type 2

Dx by finding "Sea Blue" histiocytes in bone marrow, supranuclear gaze palsy (upgaze). Vacuolated Lymphocytes, Sphingomyelinase def. [cmdg.org]

The diagnosis is based on the triad of vertical gaze paresis, organomegaly and foam cells (sea blue histiocytes) in the bone marrow. [neuroweb.us]

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]

Tryptophanemia

Dx by finding "Sea Blue" histiocytes in bone marrow, supranuclear gaze palsy (upgaze). Vacuolated Lymphocytes, Sphingomyelinase def. [cmdg.org]

Familial Dyskinesia and Facial Myokymia

The diagnosis is based on the triad of vertical gaze paresis, organomegaly and foam cells (sea blue histiocytes) in the bone marrow. [neuroweb.us]

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]

Dysmyelination with Jaundice

marrow, spleen, liver sea-blue histiocytes in bone marrow of patients with advanced disease aka Nova scotia type due to mutation in NPC1 gene, in people from Nova Scotia [quizlet.com]

[…] dysarthria, dysphagia, dementia; also galactic cataplexy, choreoathetosis, seizures can be seen skin fibroblasts demonstrate impaired cholesterol esterification foamy cells in bone [quizlet.com]

Intermittent Maple Syrup Urine Disease

Laboratory Bone marrow: Foam cells; Sea-blue histiocytes Plasma chitotriosidase activity: High Skin fibroblasts Intracellular accumulation of cholesterol (Filipin fluoroscence [neuromuscular.wustl.edu]

Hallervorden-Spatz Syndrome

histiocytes in bone marrow and/or abnormal cytosomes in circulating lymphocytes. [pediatricneurologybriefs.com]

histiocytes in bone marrow. [ncbi.nlm.nih.gov]

[…] family history consistent with autosomal recessive inheritance Hypo-intense areas on MRI involving the basal ganglia Abnormal cytosomes in circulating lymphocytes and/or sea-blue [advbiores.net]

Lethal Ataxia with Deafness and Optic Atrophy

marrow, spleen, liver sea-blue histiocytes in bone marrow of patients with advanced disease aka Nova scotia type due to mutation in NPC1 gene, in people from Nova Scotia [quizlet.com]

Primary Torsion Dystonia 6

The diagnosis is based on the triad of vertical gaze paresis, organomegaly and foam cells (sea blue histiocytes) in the bone marrow. [neuroweb.us]

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]

Pick Disease of The Brain

Cytology of a bone marrow aspirate disclosed so-called sea blue histiocytes and Niemann-Pick cells, a result strongly suggestive of Niemann-Pick disease type B or C. [jnnp.bmj.com]

Cerebral Lipidosis

Adult dystonic lipid sis was diagnosed from the clinical picture and demonstration of foamy and sea-blue histiocytes in bone marrow. [n.neurology.org]

Total Parenteral Nutrition

Bone marrow examination revealed an infiltrate of sea-blue histiocytes and cytochemistry confirmed these to be lipid laden macrophages. [ncbi.nlm.nih.gov]

Piebald Trait - Neurologic Defects Syndrome

This disorder is characterized by SPLENOMEGALY and the sea-blue histiocytes in the spleen and bone marrow after May Grunwald staining. [mendelian.co]

SEA-BLUE HISTIOCYTE DISEASE Is also known as sea-blue histiocytosis, histiocytosis, sea-blue; Related symptoms: Autosomal recessive inheritance Seizures Ataxia Peripheral [mendelian.co]

[…] caused by an inborn error involving APOLIPOPROTEINS E leading to abnormal LIPID METABOLISM and the accumulation of GLYCOSPHINGOLIPIDS, particularly SPHINGOMYELINS in the HISTIOCYTES [mendelian.co]

Adult-Onset Autosomal Recessive Cerebellar Ataxia

The diagnosis is based on the triad of vertical gaze paresis, organomegaly and foam cells (sea blue histiocytes) in the bone marrow. [neuroweb.us]

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]

Hereditary Cerebellar Degeneration

Dx by finding "Sea Blue" histiocytes in bone marrow, supranuclear gaze palsy (upgaze). Vacuolated Lymphocytes, Sphingomyelinase def. [cmdg.org]

Hereditary Progressive Mucinous Histiocytosis

Sea blue histiocytes in the bone marrow of variant granulomatous disease with residual monocyte NADPH-oxidase activity. Br J Haematol 1991;78:278-80. 93. [yumpu.com]

Sea-blue histiocyte syndrome in bone marrow secondary to total parental nutrition including fat-emulsion sources: a clinicopathologic study of seven cases. [yumpu.com]

Sea-blue histiocytes and Gaucher cell s in bone marrow of patients with chronic myeloid leukemia. J Clin Pathol 1988;41:960-2. 73. Ganguly S, Cunningham MT. [yumpu.com]

Blepharofacioskeletal Syndrome

The diagnosis is based on the triad of vertical gaze paresis, organomegaly and foam cells (sea blue histiocytes) in the bone marrow. [neuroweb.us]

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]

Alcoholic Cerebellar Degeneration

The diagnosis is based on the triad of vertical gaze paresis, organomegaly and foam cells (sea blue histiocytes) in the bone marrow. [neuroweb.us]

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]

Spinocerebellar Ataxia with Rigidity and Peripheral Neuropathy

The diagnosis is based on the triad of vertical gaze paresis, organomegaly and foam cells (sea blue histiocytes) in the bone marrow. [neuroweb.us]

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]

X-Linked Parkinsonism with Spasticity

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]

Subacute Cerebellar Degeneration

The diagnosis is based on the triad of vertical gaze paresis, organomegaly and foam cells (sea blue histiocytes) in the bone marrow. [neuroweb.us]

Bone marrow contains sea blue histiocytes. The gene locus ( PANK2 ) has been identified on chromosome 20. Treatment of patients with HSD is largely symptomatic. [neuroweb.us]