Bone Pain: Causes & Reasons

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Possible Causes for Bone Pain

Vitamin D Deficiency

METHODS: Patients with leg pain, defined as local pain and tenderness over tibial bones for ≥ 6 weeks were consecutively selected. [ncbi.nlm.nih.gov]

Patients with vitamin D deficiency can present with nonspecific bone pain and findings on radionuclide bone scanning that may suggest metastatic malignancy. [ncbi.nlm.nih.gov]

All had generalized bone pain and tenderness, muscle weakness, stooping posture, difficulty walking, and waddling gait due to severe proximal muscle weakness for a period [ncbi.nlm.nih.gov]

Periostitis

A renal transplant recipient who was on voriconazole for invasive aspergillosis developed diffuse debilitating symmetrical bone pain. [ncbi.nlm.nih.gov]

The diagnosis of periostitis was made by the documentation of bone pain, elevation of serum alkaline phosphatase and characteristic findings on radionuclide bone imaging in [ncbi.nlm.nih.gov]

We review the previous literature regarding syphilitic bone pain and periostitis. [ncbi.nlm.nih.gov]

Stage IV Prostate Carcinoma

Chemotherapy can also be highly effective in reducing bone pain. [pcf.org]

Effective therapies are available to halt or slow cancer growth and to relieve symptoms, such as bone pain and weakness, and make your quality of life the best it can be. [healthmonitor.com]

bone loss, fracture, and joint pain. [zerocancer.org]

Osteoporosis

Transient osteoporosis of the hip (TOH) is characterized by bone pain, osteopenia, and bone marrow edema in the absence of trauma. [ncbi.nlm.nih.gov]

Improvement of bone density, pain, and quality of life was achieved. [ncbi.nlm.nih.gov]

Most claim their bone pain is completely gone. The best part is that bone pain usually goes away within 2-3 hours after the operation!). [parathyroid.com]

Osteomyelitis

Chronic osteomyelitis causes intermittent (months to many years) bone pain, tenderness, and draining sinuses. [merckmanuals.com]

The infected bone becomes inflamed, resulting in severe bone pain, fever and the formation of pus. [healthcommunities.com]

Acute osteomyelitis is suspected in patients with localized peripheral bone pain, fever, and malaise or with localized refractory vertebral pain, particularly in patients [merckmanuals.com]

Malignant Neoplasm of the Lung

If the cancer has spread to the bones, it may cause bone pain, often in the vertebrae or ribs. [cancercenter.com]

Pain. Advanced lung cancer that spreads to the lining of a lung or to another area of the body, such as a bone, can cause pain. [mayoclinic.org]

Signs and symptoms that might appear if the cancer has spread to other places include bone pain, headache, muscle weakness and/or eyelid drooping. [my.clevelandclinic.org]

Multiple Myeloma

(who, 2001) Malignant neoplasm of plasma cells usually arising in the bone marrow and manifested by skeletal destruction, bone pain, and the presence of anomalous immunoglobulins [icd9data.com]

Here we report a patient with MM presenting with renal failure, anemia, and bone pain. The renal biopsy showed DDD. [ncbi.nlm.nih.gov]

Bone problems. Multiple myeloma can also affect your bones, leading to bone pain, thinning bones and broken bones. Reduced kidney function. [mayoclinic.org]

Schnitzler Syndrome

Often, the areas of hyperostosis coincide with areas of symptomatic bone pain, such as the iliac bone, tibia, femur, and vertebral column. See Workup for more detail. [emedicine.com]

Schnitzler syndrome encompasses monoclonal gammopathy, urticaria, inflammation, recurrent fever, bone pain and arthralgia, with occasional lymphadenopathy and/or hepatosplenomegaly [ncbi.nlm.nih.gov]

Schnitzler syndrome - tense, generalized chronic urticaria, joint or bone pain, and monoclonal gammopathy of kappa type. [medical-dictionary.thefreedictionary.com]

Fungal Osteomyelitis

Osteomyelitis is a painful bone infection. It usually goes away if treated early with antibiotics. If not, it can cause permanent damage. What is osteomyelitis? [nhs.uk]

A nuclear imaging method to evaluate any degenerative and/or arthritic changes in the joints; to detect bone diseases and tumors; to determine the cause of bone pain or inflammation [chop.edu]

bone Long-term outlook for a child with osteomyelitis In most cases, the infection is cured with antibiotic medication. [stanfordchildrens.org]

Gaucher Disease

Clinically apparent bony involvement, which occurs in more than 20% of patients with Gaucher disease, can present as bone pain or pathologic fractures. [emedicine.medscape.com]

(joint pain, bone fractures, etc). [symptoma.com]

Medicines may be given to: Replace the missing GBA (enzyme replacement therapy) to help reduce spleen size, bone pain, and improve thrombocytopenia. [nlm.nih.gov]

Osteosarcoma

How bone pain is experienced may vary. [healthline.com]

Herein, we presented a 50-year-old man patient who visited hospital due to local bone pain in the left leg. He was initially diagnosed with osteoblastic osteosarcoma. [ncbi.nlm.nih.gov]

Symptoms of osteosarcoma can mimic growing pains — pain in the legs caused by normal bone growth. However, growing pains typically stop during the early teenage years. [healthline.com]

Osteomyelitis of the Tibia

Bone lesion biopsy (Medical Encyclopedia) Bone pain or tenderness (Medical Encyclopedia) Disseminated tuberculosis (Medical Encyclopedia) Osteomyelitis (Medical Encyclopedia [icdlist.com]

Acute osteomyelitis is suspected in patients with localized peripheral bone pain, fever, and malaise or with localized refractory vertebral pain, particularly in patients [merckmanuals.com]

Osteomyelitis is a painful bone infection. It usually goes away if treated early with antibiotics. If not, it can cause permanent damage. What is osteomyelitis? [nhs.uk]

Chronic Pyogenic Osteomyelitis

This may be followed by an increase in fever (104-105 degrees Fahrenheit), deep localized bone pain, chills, sweating, swelling and painful or limited movement of the nearby [rarediseases.org]

For this reason, it is very important to seek medical attention whenever the bone pain worsens and presents itself along with fever. [ic.steadyhealth.com]

The child is toxic and ill and complains of bone pain. [www0.sun.ac.za]

Paget Disease of the Bone

Bisphosphonate therapy is primarily indicated for patients who have bone pain arising from increased metabolic activity in affected bones. [ncbi.nlm.nih.gov]

They are thought to reduce bone turnover, improve bone pain, promote healing of osteolytic lesions and restore normal bone histology [ 1 ]. [patient.info]

There was rapid complete relief of bone pain accompanied by biochemical improvement or normalization in all cases. [ncbi.nlm.nih.gov]

Familial Paget Disease of Bone

They are thought to reduce bone turnover, improve bone pain, promote healing of osteolytic lesions and restore normal bone histology [ 1 ]. [patient.info]

Most patients remain asymptomatic for prolonged periods of time; few suffer from bone pain, joint pain secondary to osteoarthritis, fractures due to bone instability, or skeletal [symptoma.com]

When symptoms occur, the most common complaints are bone pain and/or deformity. [patient.info]

Osteomalacia

[…] are achy bone pain and skeletal muscle weakness, fractures, and other complications ( TABLE 1 ). 1,2 Osteomalacia is most often caused by a vitamin D deficiency. 2 Even though [uspharmacist.com]

Here, we present the case of a 31-year-old man who has been suffering from generalised bone pains and a spine deformity that led to loss of height. [ncbi.nlm.nih.gov]

We report a 39-year-old male who presented with polydipsia, polyuria, and multiple bone pain. [ncbi.nlm.nih.gov]

Parathyroid Adenoma

We report one such incidence of a 14 years old girl who presented with bone pains short stature, and generalized muscle wasting. [ncbi.nlm.nih.gov]

We report a case of a 70-year-old man with a history of total parathyroidectomy and thymectomy presented with a lack of appetite, nausea, and generalized bone pain, polydipsia [ncbi.nlm.nih.gov]

Introduction Adenomas of the parathyroid gland typically present with symptoms of hyperparathyroidism, manifested by fatigue, bone pain, abdominal pain, weakness, dyspepsia [ncbi.nlm.nih.gov]

Primary Myelofibrosis

Painful episodes of splenic infarction may occur. The patient becomes cachectic and may experience severe bone pain, especially in the upper legs. [accessmedicine.mhmedical.com]

Involved field radiotherapy is most useful for post-splenectomy hepatomegaly, non-hepatosplenic EMH, PMF-associated pulmonary hypertension, and extremity bone pain. [ncbi.nlm.nih.gov]

[…] in rate of 20% The most common locomotor manifestation in Multiple Meyloma: * Clinical; bone pain in rate of 90% * Radiological: dactalytic positions in rate of 50 % [tishreen.edu.sy]

Metatarsal Stress Fracture

How it affects your running The pain from a metatarsal stress fracture is usually felt on the top of the foot, over the affected metatarsal bone. [runnersrescue.com]

The pain from a metatarsal stress fracture is usually felt on the top of the foot, over the affected metatarsal bone. [jointpaininfo.com]

Other causes of forefoot pain • Morton's neuroma (benign tumor of a nerve running between the metatarsals) • Metatarsalgia (painful and inflammation of the metatarsal bones [njfootdoc.com]

Familial Hypophosphatemia

Bone pain, fatigue, myopathy, as well as growth and dental abnormalities are usually encountered, whereas cardiac and pulmonary failure may ensue in severe cases. [symptoma.com]

[…] of the spine (termed scoliosis) Hearing loss Frequent muscle cramps Bone pain with frequent fractures due to weak bones. [dovemed.com]

More severe cases can present with neurological complaints (altered speech, confusion, seizures, hearing impairment), bone pain, poor teeth status, and fatigue. [symptoma.com]

X-Linked Hypophosphatemia

Patients with X-linked hypophosphatemia have short stature, rickets, bone pain and dental abscesses. [ncbi.nlm.nih.gov]

In adulthood, therapy is usually continued in symptomatic patients and generally aims at reducing bone pain. [orpha.net]

Current therapy is oral phosphate and vitamin D which effectively treats the rickets and bone pain but does not adequately improve short stature. [ncbi.nlm.nih.gov]

Familial Myelofibrosis

It can be used to treat an enlarged spleen, bone pain or tumours that develop outside of the bone marrow. [cancer.ca]

pain What causes MF? [canadianmpnnetwork.ca]

In turn, this causes the liver and spleen to become enlarged and creates some of the symptoms such as abdominal pain, feeling full, weight loss, fatigue, itching, bone pain [cancercare.org]

Carcinoma of the Prostate

pain, weakness, and fractures. [casereports.bmj.com]

If you have bone pain or doctors think cancer may have spread to your bones, brain, or spinal cord, doctors will do: Bone scan Your doctors will work with you to decide which [merckmanuals.com]

}uphs.upenn.edu Abstract Tumour-induced osteomalacia (TIO), or oncogenic osteomalacia, is a paraneoplastic syndrome marked by hypophosphataemia, renal phosphate wasting, bone [casereports.bmj.com]

Leukemia

So, it's more generalized bone pain. [khanacademy.org]

pain or tenderness These symptoms are often vague and can resemble the flu, so it’s important for patients to be aware of changes in their body and make an appointment to [utswmed.org]

This may result in infections, anemia, and easy bleeding, as well as bone pain and pain or a feeling of fullness below the ribs on the left side. [westcancercenter.org]

Hypophosphatasia

Fractures and bone pain usually characterise the adult form. A 9-year-old girl was referred for repetitive fractures after minimal trauma. [ncbi.nlm.nih.gov]

Conclusion: We report a novel mutation of ALPL presenting with short stature and bone pain. [abstracts.eurospe.org]

Childhood form is caractherized by short stature, premature loss of decidous teeth and diffuse bone pain associated with a pathological bone fracture in the past. [ncbi.nlm.nih.gov]

Neuroblastoma

The most frequent manifestations were: fever (25%), abdominal pain (22%), abdominal mass (19%), and bone pain (19%). [ncbi.nlm.nih.gov]

Many symptoms of neuroblastoma are caused by pressure from the tumor or bone pain if the cancer has spread to the bones. [cancer.net]

Bone pain and limp can be interpreted as synovitis of the hip. [orpha.net]

Osteogenesis Imperfecta

Bone pain ameliorated just after the first cycle of pamidronate, while the activity and mobility increased quickly. [ncbi.nlm.nih.gov]

Bone pain In one trial, bone pain was assessed using the Wong‐Baker FACES at baseline, 6 and 12 months and did not identify a clear increase in bone pain compared to baseline [doi.org]

Acute osteomyelitis is suspected in patients with localized peripheral bone pain, fever, and malaise or with localized refractory vertebral pain, particularly in patients [msdmanuals.com]

Systemic Mastocytosis

[…] patients reported improvement in bone pain after bisphosphonate treatment. [ard.bmj.com]

Nausea, stomach pain, diarrhea and vomiting. Bone pain. Flushing (when skin all over the body turns red). A drop in blood pressure. Fainting. [my.clevelandclinic.org]

Fig. 7: This 29 year old Indian woman presented with bone pain and lethargy. Radiographically all her bones have increased density with a blurred trabecular pattern. [healio.com]

Osteoid Osteoma

Osteoid osteomas are benign bone lesions that present with bone pain in children and young adults. [ncbi.nlm.nih.gov]

OBJECTIVES: To assess the efficacy of bisphosphonate therapy on bone pain in patients with osteoid osteoma (OO) (main objective), and to describe bisphosphonate-induced changes [ncbi.nlm.nih.gov]

CONCLUSION Osteoid osteoma is a relatively common benign bone lesion in children and young adults that can present with nontraumatic bone pain. [appliedradiology.com]

Chronic Phase of Chronic Myeloid Leukemia

[…] marrow to other tissues and organs CML cells with new chromosome abnormalities Symptoms such as Fever Fatigue Shortness of breath Abdominal pain Bone pain Enlarged spleen [lls.org]

When this happens, the blood counts worsen and patients can experience high fever, bone pain and painful enlargement of the spleen. [ucsfhealth.org]

Signs and symptoms are most severe in this phase, including a massively enlarged spleen, bone pain, and weight loss. [icdlist.com]