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602 Possible Causes for Bone Pain, Leukocytosis, Splenomegaly

  • Primary Myelofibrosis

    Involved field radiotherapy is most useful for post-splenectomy hepatomegaly, non-hepatosplenic EMH, PMF-associated pulmonary hypertension, and extremity bone pain.[ncbi.nlm.nih.gov] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Leukocytosis is occasionally seen in patients with presumptive but undiagnosed myeloproliferative disorders (MPD).[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Symptoms Signs  Fatigue  Malaise  Early satiety  Weight loss  Fever  Abdominal painBone pain  Pruritis  Splenomegaly  Abnormal blood counts  Abnormal peripheral[slideshare.net] CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] […] a Philadelphia (Ph) chromosome without DNA breakpoints in the M-bcr region; (3) the spontaneous loss of detectable Ph-positive cells, 5 years after the first finding of leukocytosis[ncbi.nlm.nih.gov]

  • Leukemia

    So, it's more generalized bone pain.[khanacademy.org] Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] Evaluation Step 0: Leukocytosis ( White Blood Cell Count 11,000/mm3) Confirmed with a second Complete Blood Count with differential No other obvious cause for Leukocytosis[fpnotebook.com]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] During multivariable analysis, leukocytosis 15 10 9 /l, palpable splenomegaly and grade 1 BM reticulin fibrosis remained significant.[ncbi.nlm.nih.gov] Treatments for Symptoms Aspirin can relieve bone pain and burning feelings in your hands or feet that you may have as a result of PV.[nhlbi.nih.gov]

  • Chronic Myeloid Leukemia

    pain,... )[cmleukemia.com] Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] Her disease was managed during pregnancy using interferon-α alone despite persistent leukocytosis.[ncbi.nlm.nih.gov]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    […] in the bones and joints Pain in the abdomen How is CML diagnosed?[symptoma.com] Splenomegaly of more than 10 cm, basophilia and leukocytosis were associated with a shorter median survival but was not statistically significant.[ncbi.nlm.nih.gov] Abstract A previously healthy 11 year-old-white boy presented with persistent mild leukocytosis and a posterior mediastinal mass.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    […] marrow to other tissues and organs CML cells with new chromosome abnormalities Symptoms such as Fever Fatigue Shortness of breath Abdominal pain Bone pain Enlarged spleen[lls.org] Those complaints are generally associated with anemia and splenomegaly.[symptoma.com] Important diagnostic features are severe leukocytosis (up to 500,000/μl ), basophilia, and extreme splenomegaly.[amboss.com]

  • Acute Myelocytic Leukemia

    It can also be used to treat bone pain that comes from bone affected by the leukemia.[web.archive.org] Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections.[medical-dictionary.thefreedictionary.com] Thus, the bone marrow and peripheral blood are characterized by leukocytosis with a predominance of immature cells, primarily blasts.[ncbi.nlm.nih.gov]

  • Acute Lymphoblastic Leukemia

    Abstract A 47-year-old man presented with abdominal pain, vomiting, and bone pain.[ncbi.nlm.nih.gov] Splenomegaly and thrombocytopenia were frequently observed more in CD200 patients. Increased frequency of CD34 was associated with CD200 and CD56 patients.[ncbi.nlm.nih.gov] , hematological, and immunocytological) parameters pointed towards a diagnosis of Wilms tumor in our case, the subsequent development of thrombocytopenia and lymphocytic leukocytosis[ncbi.nlm.nih.gov]

  • Childhood Acute Lymphoblastic Leukemia

    On examination, the boy was mildly pale, severe bone pain, no organomegaly but few occipital group of lymphnode were palpable.[ncbi.nlm.nih.gov] The child redeveloped splenomegaly and fever, and then suffered an acute decompensation with hypoxemia, tachypnea, splenomegaly, and cardiac gallop.[ncbi.nlm.nih.gov] Extreme leukocytosis is seen in many cases, but this finding can be absent in aleukemic forms.[symptoma.com]

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