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47 Possible Causes for Bone-Specific Alkaline Phosphatase Increased

  • Osteoporosis

    Increased rates of osteoclastic bone resorption, measured by the level of collagen breakdown products, as well as increased bone formation, measured by bone-specific alkaline[doi.org] phosphatase, osteocalcin, or procollagen peptide levels, are associated with an increase in risk for bone loss and fragility fractures.[doi.org] Another key predictor is the rate of bone remodeling.[doi.org]

  • Burn Injury

    Osteocalcin, bone-specific alkaline phosphatase (BALP), intact N-terminal type 1 procollagen propeptide (P1NP), and cross-linked C-telopeptide (CTX) acutely reflected the[ncbi.nlm.nih.gov] In contrast, levels of soluble receptor activator of NF-κB ligand (sRANKL) increased over time.[ncbi.nlm.nih.gov] increase of Ct.Po at the radius (R 2  0.41), followed by the reduction of trabecular thickness at the tibia (R 2  0.28).[ncbi.nlm.nih.gov]

  • High Output Heart Failure

    […] with PDB are usually initially identified incidentally by radiograph or by an elevated bone-specific alkaline phosphatase obtained on routine chemistry panels.[clevelandclinicmeded.com] Total serum alkaline phosphatase activity, which is a reflection of increased bone formation, is elevated in 85% of untreated PDB patients. 15 In studies that compare various[clevelandclinicmeded.com] […] markers of bone turnover in patients with PDB, bone-specific alkaline phosphatase has a diagnostic sensitivity of 84%, and total serum alkaline phosphatase has a diagnostic[clevelandclinicmeded.com]

  • Pediatric Crohn's Disease

    Bone-specific alkaline phosphatase levels, a biomarker of bone formation, increased a median of 75% (P .001) during induction with associated 12-month improvements in trabecular[ncbi.nlm.nih.gov] […] activity index decreased during the 10-week induction (P .001), in association with subsequent gains in height, trabecular BMD, cortical area (due to recovery of endocortical bone[ncbi.nlm.nih.gov]

  • Cholestasis

    In most PBC patients (95%), the level of bone-specific alkaline phosphatase was above the normal range, indicating increased bone formation.[ncbi.nlm.nih.gov]

  • Calciphylaxis

    Extended dialysis with low calcium dialysate concentration and citrate anticoagulation, and administration of teriparatide led to a further increase in bone-specific alkaline[ncbi.nlm.nih.gov] […] clearly showed adynamic bone disease.[ncbi.nlm.nih.gov] phosphatase activity and most importantly, resulted in an activated bone turnover as confirmed by a second bone biopsy 11 weeks later.[ncbi.nlm.nih.gov]

  • Hypercalcemia

    In April 2015, serum levels of type 1 collagen C-terminal cross-linked telopeptide, procollagen type 1 N-terminal propeptide and bone-specific alkaline phosphatase were still[ncbi.nlm.nih.gov] From then on, I-Ca and PTH normalized and the bone turnover markers (BTM) decreased.[ncbi.nlm.nih.gov] CONCLUSION: In this case report, we describe increased BTMs and hypercalcemia associated with discontinuation of 10 years treatment with denosumab.[ncbi.nlm.nih.gov]

  • Tall Stature-Scoliosis-Macrodactyly of the Great Toes Syndrome

    You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser . Format Definition An overgrowth syndrome characterized by tall stature, long hands and feet with arachnodactyly, macrodactyly of the great toes, scoliosis, coxa valga and slipped[…][uniprot.org]

  • Carcinoma of the Larynx

    […] antigen (PSA), bone alkaline phosphatase (BAP), and total alkaline phosphatase (ALP).[news.cancerconnect.com] Blood levels of alkaline phosphatase are increased in patients with bone metastases.[news.cancerconnect.com] […] substitute) and the two groups were compared for clinical and x-ray indications of cancer progression and change from baseline in bio-markers of progression, including prostate specific[news.cancerconnect.com]

  • Primary Biliary Cirrhosis

    Hypophosphatemic osteomalacia was diagnosed from a low serum phosphorus level, 1,25-dihydroxyvitamin D3 level, high levels of bone specific alkaline phosphatase and the findings[ncbi.nlm.nih.gov] […] of bone scintigraphy, although a bone biopsy was not performed.[ncbi.nlm.nih.gov] Twenty four hour urine demonstrated a low renal fractional tubular reabsorption of phosphate, increased fractional excretion of uric acid and generalized aminoaciduria.[ncbi.nlm.nih.gov]

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