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75 Possible Causes for Bone-Spicule Pigment Clumping

  • Pigmented Paravenous Retinochoroidal Atrophy

    Fluorescein angiography showed hyperfluorescence due to the pigment epithelial atrophy together with hypofluorescence corresponding to bone spicule pigment clumping.[] A marked bone spicule pigment clumping together with the atrophy was noted left eye.[] Both fundi showed patches of retinochoroidal atrophy and pigmentation along the retinal veins in all patients.[]

  • Usher Syndrome Type 1

    spicule pigment clumping spreading into the peripheral retina.[] Spicule/ Clumped Pigmentation OU Granular Macula OU CDH23 22.8 (5) 20/54 (33.6, 9) 3487.9 (37.0, 7) 1.49 (36.7, 8) 4/9 patients 8/9 patients 5/9 patients MYO7A 20.5 (10)[] On fluorescein angiography, both eyes showed diffuse hyperfluorescence due to pigment epithelial atrophy together with hypofluorescence, corresponding to bone spicule pigment[]

  • Retinitis Pigmentosa

    […] ndings include: Pigment clumping or bone spicule pigmentation, waxy pallor of optic nerve, retinal arteriolar narrowing, formation of atrophy of the RPE, epiretinal membrane[] These include narrowed retinal arterioles, a waxy appearance of the optic nerve, and characteristic bone-spicule clumping of retinal pigment.[] The classic sign of RP is clumps of pigment in the peripheral retinal called "bone-spicules."[]

  • Peripheral Vasoproliferative Retinopathy

    , referred to as "bone-spicule formation" (Figure 10-19).[] The most characteristic ophthalmoscopic findings are narrowing of the retinal arterioles, mottling of the retinal pigment epithelium, and peripheral retinal pigment clumping[]

  • Retinitis Pigmentosa 7

    The pigmentary retinopathy is typical for classical retinitis pigmentosa with vascular attenuation, perivascular bone-spicule pigment clumping, optic atrophy, and generalized[] The pigment clumps up into those pigmented bone spicules, the blood vessels are narrower and more tortuous and the smooth yellow/orange/red color of the retina is much more[] pigment clumping).[]

  • Retinitis Pigmentosa 66
  • Retinitis Pigmentosa 32

    The retinal picture resembles retinitis pigmentosa with ‘bone spiculepigment clumps, vascular attenuation, and pale optic nerve heads.[] […] in bone-spicule formations, attenuated retinal vessels, and waxy pallor of the optic disc.[] Signs In chronological order : • Arteriolar narrowing • Peripheral bone-spicule pigments 21.[]

  • Boucher-Neuhäuser Syndrome

    Some clumps of pigment deposition (without bone spicule configuration) were also seen. The retinal vessels and optic disc appeared normal ( Fig. 2A, B ).[] Ophthalmoscopy showed extensive atrophic changes of the retinal pigment epithelium and choriocapillaris in the posterior pole and midperiphery of both eyes, with visible choroidal[]

  • Cytomegalovirus Retinitis

    At some point, the ophthalmologist observes relatively characteristic clumping of pigment in the retina in a pattern described as resembling bone spicules.[]

  • Goldmann-Favre Syndrome

    Key features include “bone-spiculepigment clumping, thinning and atrophy of the retinal pigment epithelium in the mid- and far-peripheral retina, relative preservation of[] […] of pigment in the mid-peripheral fundus with little or no evidence of bone spicule formation. 4 This pattern of pigmentation occurs in retinitis pigmentosa (RP) with preserved[] ERG). 1– 3 The term “clumped pigmentary retinal degeneration” (CPRD) describes a group of patients with decreased night and peripheral vision who have round and irregular clumps[]

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