Create issue ticket

24 Possible Causes for Bone Spicules, Knee Pain, Lactate Dehydrogenase Increased

  • Multiple Myeloma

    Also, reflecting this aggressive clinical presentation, a higher proportion of patients with pPCL have significant leukocytosis, elevated lactate dehydrogenase (LDH) and β2[] This fluid is predominantly blood, but mixed in are bone marrow particles (spicules) which are then spread onto glass slides, stained, and examined by hematologists and pathologists[] CASE REPORT A 56-year-old man with multiple myeloma presented with chronic polyarticular pain and swelling.[]

  • Ewing's Sarcoma

    Uncommon features included epiphyseal involvement (4%), sclerosis (4%), expansion of bone (8%), sunray spiculation (10%), calcification in soft tissue (8%), saucerization[] Patellar tumors occur infrequently and represent an uncommon etiology of anterior knee pain.[] It may be spiculated and interrupted - sometimes there is a Codman's triangle.[]

  • Ewing Family of Tumors

    Serum concentrations of alkaline phosphatase and lactate dehydrogenase may be increased.[] It may be spiculated and interrupted - sometimes there is a Codman's triangle.[] Aggressive periosteal reaction This type of periostitis is multilayered, lamellated or demonstrates bone formation perpendicular to the cortical bone.[]

  • Bone Metastasis

    , and radiating spicules that merge with adjacent trabecula in a feathered pattern [ 12 – 15 ].[] She had knee pain, and I was very slow to recognize that she had metastatic disease in the knee because I was just not thinking that pancreatic cancer would be a primary tumor[] Extra-femoral spicules, characteristic of compensative bone formation were detected, consistent with other studies [7].[]

  • Pathological Fracture

    dehydrogenase; IPI, International prognostic index. a Relationship between patients with increased serum LDH levels and patients with available LDH level data.[] Non-ossifying fibroma In this case, a CT chest, abdomen and pelvis was performed, which identified a 1.2cm spiculated lung mass.[] A young patient presented with a progressive right knee pain and swelling that was worse on ambulation.[]

  • Paraneoplastic Syndrome

    […] serum levels of creatine kinase and lactate dehydrogenase (LDH) and an elevated erythrocyte sedimentation rate (ESR).[] In contrast to RP, intraretinal bone spicule migration is rare with either AZOOR or paraneoplastic retinopathies.[] Hypertrophic osteoarthropathy is prominent with certain lung cancers and manifests as painful swelling of the joints (knees, ankles, wrists, elbows, metacarpophalangeal joints[]

  • Mandibular Neoplasm

    Some laboratory parameters, such as alkaline phosphatase or lactate dehydrogenase (LDH) serum levels, can be increased in a few patients.[] Cystic spaces (C) and nests of neoplastic squamous (N) cells along with bone spicules at the periphery (B). (H&E 50) Figure 3 Mucoepidermoid carcinoma.[] Bilateral Knee Pain with Hyperparathyroidism. Journal of the Royal Society of Medicine , Vol. 95, Issue. 3, p. 134. CrossRef Google Scholar[]

  • Chronic Progressive External Ophthalmoplegia

    Biochemically, there is profound lactic acidosis because the NADH:NAD ratio increases, shifting the equilibrium of the lactate dehydrogenase reaction toward lactate.[] Weingeist says this retinopathy is not as dramatic as the bone spicules seen in retinitis pigmentosa. Figure 4 : Muscle Pathology.[] I also have joint pain in one knee. Is this related?[]

  • Plasmacytoma

    The serum transaminase levels were slightly increased (AST level, 37 IU/L; ALT level, 64 IU/L).[] They include-plasmacytomas, scleromyxedema, xanthomas, hyperkeratotic spicules, amyloidosis, pyoderma gangrenosum such as lesions, and Sweet's syndrome. [3] Abnormal plasma[] There was symmetrical hypoaesthesia for touch, pain, temperature, and position and vibration sense below the level of both knees. All deep tendon reflexes were absent.[]

  • Leukopenia

    More than 50% patients were increased in alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and 25–40% patients were increased in lactate dehydrogenase ([] One may note bone spicules within the marrow specimen.[] A previously healthy 42-year-old woman presented to the emergency department (ED) for arthralgias and painful lesions on her ears, feet, and knee (Figures 1 and 2) that had[]

Similar symptoms