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26 Possible Causes for Bradycardia, Hyperbilirubinemia, Onset in First Weeks or Months of Life

  • Sepsis

    Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[medlineplus.gov] Abstract A 60-year-old woman was admitted with sepsis, relative bradycardia, CT evidence of numerous small liver abscesses and 'skin bronzing' consistent with hereditary haemochromatosis[ncbi.nlm.nih.gov] Hyperbilirubinemia did not return in 3 months.[ncbi.nlm.nih.gov]

  • Neonatal Sepsis

    Early-onset sepsis is seen in the first week of life. Occurs after 1 week and before 3 months of age.[omicsonline.org] Bradycardia (slow heart rate) Tachycardia (increased heart rate) Temperature instability Low blood pressure Neurological changes : Irritability, lethargy, and non-responsiveness[michigancerebralpalsyattorneys.com] The incidence rate of hyperbilirubinemia due to infection is unknown (7,8).[ijp.mums.ac.ir]

  • Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] ICP has been found to be associated with increased risk of preterm delivery, meconium staining of amniotic fluid, fetal bradycardia, fetal distress and fetal demise [2], [[journals.plos.org] We believe our patient’s persistent direct hyperbilirubinemia with biopsy-confirmed cholestasis was also likely related to his AHC.[pediatrics.aappublications.org]

  • Sepsis in Premature Infants

    BACKGROUND: Late-onset sepsis in the premature infant is frequently revealed by severe, unusual and recurrent bradycardias.[ncbi.nlm.nih.gov] Other signs and symptoms include lethargy, temperature instability, hyperbilirubinemia, bradycardia, seizures and acidosis.[uichildrens.org] Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[medlineplus.gov]

  • Intrahepatic Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] ICP increases particularly when associated with fasting serum bile acid levels 40umol/L the risk of preterm delivery meconium staining of amniotic fluid fetal bradycardia,[flipper.diff.org] Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution[ncbi.nlm.nih.gov]

  • Neonatal Infection

    Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[medlineplus.gov] Published Date 01 Jun 2018 Last Updated 21 Nov 2018 Apnoea is defined as no effective respiratory effort for 20 seconds or for 10 seconds if associated with bradycardia ([health.vic.gov.au] […] low-risk for having a serious bacterial illness: [2] generally well-appearing previously healthy full term (at 37 weeks gestation) no antibiotics perinatally no unexplained hyperbilirubinemia[en.wikipedia.org]

  • Laryngeal Stridor

    Congenital abnormalities of the upper airway typically present in the first few weeks to months of life and are the most common causes of stridor (87%).[medicine.uiowa.edu] The time between onset of laryngospasm to hypoxia to bradycardia to cardiac arrest can be a matter of minutes, especially in small children.[airwayjedi.com] […] headache, memory impairment, cerebrospinal bleeding, hyponatremia, syndrome of inappropriate antidiuretic hormone secretion, nausea and vomiting, uterine rupture, neonatal hyperbilirubinemia[ccforum.biomedcentral.com]

  • Dilated Cardiomyopathy Type 2B

    It can manifest as acute heart failure at any time of life, although the onset is often in the first weeks or months of life as the first manifestation, as in our case.2–6[revespcardiol.org] This pacemaker also will help people with heart block or some bradycardias (slow heart rates). Implantable cardioverter defibrillators (ICD).[medicinenet.com] […] recessive UGT1A1 2q37.1 Crigler-Najjar syndrome, type I 218800 191740 Autosomal recessive UGT1A1 2q37.1 [Gilbert syndrome] 143500 191740 Autosomal recessive UGT1A1 2q37.1 Hyperbilirubinemia[mnglabs.com]

  • Pneumatosis Vaginalis

    […] two years of life, peak incidence at 6 weeks of age Seasonal pattern - winter and early spring months Clinical Picture Symptoms • Sudden onset of respiratory difficulty •[flashcardmachine.com] Recent problems include apnea and bradycardia of prematurity and feeding intolerance.[hawaii.edu] Hypertrophic Cardiomyopathy, Hyperbilirubinemia, & Polycythemia 6.[cram.com]

  • Early Infantile Epileptic Encephalopathy Type 2

    Clinical description Onset of EIEE occurs within the first 3 months of life but some present within the first few weeks after birth.[orpha.net] […] a 27-month-old female with atypical early infantile epileptic encephalopathy (EIEE), who developed tonic spasms, partial seizures and myoclonic jerks along with episodic bradycardia[ncbi.nlm.nih.gov] (C0117) was delivered at the age of 28 weeks and was diagnosed with hyperbilirubinemia, at the age of one year and one month his DQ indicates moderate ID. (2).[nature.com]

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