Bradykinesia: Causes & Reasons

Possible Causes for Bradykinesia

Table 1 Parkinson’s disease symptoms Bradykinesia Bradykinesia refers to slowness of movement and is the most characteristic clinical feature of PD, although it may also be [web.archive.org]

Rest tremor, bradykinesia, rigidity and loss of postural reflexes are generally considered the cardinal signs of PD. [doi.org]

In a study assessing recordings from single cortical neurons in rats with haloperidol induced bradykinesia, a decrease in firing rates correlated with bradykinesia. 29 Functional [web.archive.org]

Progressive Supranuclear Palsy

UPDRS total motor scores and subscores for bradykinesia and axial motor deficits did not correlate with R2* values of the five brain regions. [ncbi.nlm.nih.gov]

PSP-corticobasal syndrome (PSP-CBS) is characterized by progressive, asymmetric dyspraxia, limb rigidity, bradykinesia and progressive postural instability. [orpha.net]

(iv) Bradykinesia: the presence of any mention of bradykinesia or motor slowing. [doi.org]

Juvenile Paralysis Agitans of Hunt

Diseases related with Melanoma and Bradykinesia In the following list you will find some of the most common rare diseases related to Melanoma and Bradykinesia that can help [mendelian.co]

32 HP:0002067 9 parkinsonism 32 HP:0001300 Symptoms via clinical synopsis from OMIM: 57 Neuro: dysarthria gait disturbance tremor rigidity bradykinesia more Misc: onset in [malacards.org]

Bradykinesia MedGen UID: 115925 •Concept ID: C0233565 • Sign or Symptom Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution [ncbi.nlm.nih.gov]

Shy-Drager Syndrome

While the limited and transient beneficial effect of levodopa on the bradykinesia in our case is possibly due to the progressive loss of striatal dopaminergic receptors seen [ncbi.nlm.nih.gov]

For patients afflicted with this condition, rigidity and bradykinesia are the primary extrapyramidal symptoms which are present. [ncbi.nlm.nih.gov]

A previously healthy 60 years old female patient presented with bradykinesia, postural instability and increased rigidity of both upper and lower limbs for 2 years and was [ncbi.nlm.nih.gov]

Dementia with Lewy Bodies

[…] clinical features include: recurrent visual hallucinations; cognitive fluctuations; REM sleep behaviour disorder; and one or more spontaeous cardinal features of parkinsonism: bradykinesia [bestpractice.bmj.com]

He showed bradykinesia and small step gait with supranuclear vertical gaze palsy, especially upward gaze palsy. He was started on levodopa therapy but without response. [ncbi.nlm.nih.gov]

Postural instability and bradykinesia is noted on physical exam. [medbullets.com]

Postencephalitic Parkinson Disease

Generally, when two of the four cardinal signs occur (tremor at rest, bradykinesia, rigidity or problems with balance), a diagnosis may be made and treatment initiated. [parkinsonsmi.org]

Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. [hon.ch]

Parkinson's disease is recognized by the presence of at least three of four cardinal signs: resting tremor, cogwheel rigidity, bradykinesia/akinesia, and postural reflex impairment [parkinsonsmi.org]

Parkinsonism

However, prior studies have examined parkinsonism (defined as having bradykinesia with at least rest tremor or postural instability) mostly in premutation carriers without [ucdavis.pure.elsevier.com]

Some patients present a moderate response to levodopa that improves bradykinesia and rigidity. [orpha.net]

Subtle “bradykinesia” has been reported to occur in the “normal elderly” population, but this may reflect a non-specific slowness rather than bradykinesia as defined above [movementdisorders.org]

Methylphenyltetrahydropyridine

[…] with lewy bodies Pathophysiology neurodegeneration of dopaminergic neurons e.g., substantia nigra pars compacta leads to bradykinesia due to distruption of basal ganglia [medbullets.com]

[…] tetrahydropyridine, analogs MTMP, PEPAP Neurology A potent neurotoxin–which has an effect much like Meperidine or Demerol—that acts on neuromelanin, producing parkinsonism Clinical Bradykinesia [medical-dictionary.thefreedictionary.com]

Clinically, PD is characterized by rest tremor, rigidity, bradykinesia, and gait impairment, known as the "cardinal features" of the disease. [flipper.diff.org]

Prion Disease

The first patient experienced progressive bradykinesia, ataxia, and slurred speech developing over a two-week period. [web.archive.org]

Gaucher Disease

Initially, 17 subjects were identified with Gaucher disease and l -DOPA refractory parkinsonian manifestations that included tremor, bradykinesia, rigidity, and often cognitive [jmg.bmj.com]

Additional noted trends were that subjects carrying mutations presented an average of 4 years earlier, were more likely to have a family history of PD, and had less bradykinesia [doi.org]

Hypothyroidism

Hypothyroidism presents with the following signs and symptoms: Cardiovascular The heart muscle slows down and contractility decreases therefore the cardiac output is also decreased. Bradycardia, decreased systolic and increased diastolic blood pressure, systemic hypotension and in some severe cases, pericardial[…] [symptoma.com]

Pallidopyramidal Syndrome

Diseases related with Muscle weakness and Bradykinesia In the following list you will find some of the most common rare diseases related to Muscle weakness and Bradykinesia [mendelian.co]

Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. [malacards.org]

[…] cases Rigidity Common - Between 50% and 80% cases Accelerate your rare disease diagnosis with us Learn more Other less frequent symptoms Patients with Muscle weakness and Bradykinesia [mendelian.co]

X-Linked Parkinsonism with Spasticity

UniProtKB/Swiss-Prot : 75 Parkinsonism with spasticity, X-linked: A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia [malacards.org]

UniProtKB/Swiss-Prot : 73 Parkinsonism with spasticity, X-linked: A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia [malacards.org]

Definition A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia, and variably penetrant spasticity. [uniprot.org]

Multiple Myeloma

Multiple myeloma (MM) is the second most common hematologic malignancy in the United States, after non-Hodgkin lymphoma. Family pedigree analyses of high-risk families, case-control studies and racial disparities in disease incidence all point to a potential inherited predisposition to MM. Genome-wide association studies[…] [ncbi.nlm.nih.gov]

Secondary Parkinsonism

Bradykinesia Patients often experience bradykinesia, which is one of the cardinal feature of parkinsonism. Bradykinesia develops due to the involvement of basal ganglia. [medicaljoyworks.com]

On observing for 5 subsequent days, there was no improvement in her bradykinesia or rigidity. [mdsabstracts.org]

Department of neurology, Dong-A University College of Medicine Abstract Backgroud & Significance: Parkinsoinsm is characterized by clinical symptoms of igidity, bradykinesia [jkna.org]

Bradykinesia

More discussions about bradykinesia [medical-dictionary.thefreedictionary.com]

In PD, facial bradykinesia is primarily mediated by basal ganglia dysfunction whereas in PSP, facial bradykinesia is a consequence of a widespread degeneration involving the [ncbi.nlm.nih.gov]

Writing becomes more difficult for patients suffering from bradykinesia. © Licence Creative Commons Bradykinesia - 1 Photo [futura-sciences.us]

Classic Progressive Supranuclear Palsy Syndrome

PSP-CBS is characterized by progressive asymmetric dyspraxia, limb rigidity, bradykinesia, and progressive postural instability. [orpha.net]

PSP-corticobasal syndrome (PSP-CBS) is characterized by progressive, asymmetric dyspraxia, limb rigidity, bradykinesia and progressive postural instability. [orpha.net]

Summary Clinical description PSP-P is characterized by early parkinsonism, including limb bradykinesia, axial and limb rigidity and, in some patients, tremor, with some response [orpha.net]

Advanced Parkinson Disease

There is a correlation between onset of bradykinesia with cognitive impairment and the presence of Lewy bodies in the neocortex. [elsevier.es]

Even when patients are still able to ambulate without assistance, limited motor ability due to marked bradykinesia and inability to perform fine and alternate movements lead [ncbi.nlm.nih.gov]

Therefore, more differentiated scales with focus on motor impairment including the cardinal symptoms of PD (hypo-/bradykinesia, rigidity, rest tremor, postural instability [ncbi.nlm.nih.gov]

Juvenile Huntington Disease

There was a predominance of rigidity and bradykinesia. [ncbi.nlm.nih.gov]

HUNTINGTON'S DISEASE (WESTPHAL VARIANT) A progressive neurodegenerative disorder characterized initially by bradykinesia and rigidity then choreiform movements. [endoflifecare.tripod.com]

On examination, the child had ataxic gait, bradykinesia, oculomotor apraxia, rigidity, and signs of cerebellar involvement. Fundus examination was normal. [pediatricneurosciences.com]

Striatonigral Degeneration

The main clinical features were bradykinesia and rigidity. He also showed pseudobulbar and pyramidal syndromes. [ncbi.nlm.nih.gov]

[…] that distinguished SND from PD were the early appearance of the following symptoms and signs: (a) severe and atypical progressive parkinsonism characterized by bilateral bradykinesia [ncbi.nlm.nih.gov]

The patient, a 55-year-old woman with progressive and relatively intractable rigidity and bradykinesia, particularly of the right side, was studied with brain MR scans and [ncbi.nlm.nih.gov]

Adult-Onset Dystonia - Parkinsonism

Parkinsonism refers to all clinical states characterized by tremor, muscle rigidity, slowed movement (bradykinesia) and often postural instability. [ncbi.nlm.nih.gov]

Symptoms worsen over time and include resting tremor, muscular rigidity, bradykinesia [abnormal slowness of movement], and postural instability [impaired balance and coordination [flybase.org]

Motor parkinsonian manifestations (bradykinesia, rigidity, and less frequently tremor) vary in severity and may appear later. [neuropathology-web.org]

Extrapyramidal Disorder

Bradykinesia and rigidity are additive in hindering movement and are usually present together. [dartmouth.edu]

Since this system regulates posture and skeletal muscle tone, a result is the characteristic bradykinesia of Parkinson's. [en.wikipedia.org]

Associated with rigidity & bradykinesia Slide 10: TREMORRhythmic, sinusoidal movement Differential Diagnosis: - Myoclonus - Asterixes - Tics (Guilles de la Tourette syndrome [authorstream.com]

Primary Orthostatic Tremor

Information Links Trending Red Flags A-Z GP contract GP Training GP Locums GP Wellbeing Rigidity Impaired postural reflexes Abnormality of speech Nystagmus Irritability Jaundice Bradykinesia [gponline.com]

He had mild to moderate extrapyramidal rigidity of the limbs with asymmetric bradykinesia, more marked on the right. [jnnp.bmj.com]

After a dopa challenge (50 mg carbidopa and 200 mg levodopa) he exhibited a marked improvement of rigidity and bradykinesia. [jnnp.bmj.com]

Carbon Monoxide-Induced Parkinsonism

Associate Professor Movement Disorders Section Department of Neurological Sciences Rush University Medical Center 2 Parkinson’s Disease, Motor Abnormalities Tremor Bradykinesia [slideplayer.com]

Bradykinesia — Slowness in initiating movement. Loss of Postural Reflexes — Poor posture and balance that may cause falls; gait or balance problems. [rwjuh.edu]

Parkinson's disease is a movement disorder characterised by [ 1 ] : Tremor at rest Rigidity Bradykinesia The diagnosis is almost entirely based on clinical examination. [patient.info]

Pyramidal Tract Disorder

O, Alberts J, Machado A Abstract A fundamental challenge in the clinical care of Parkinson disease (PD) is the current dependence on subjective evaluations of tremor and bradykinesia [medworm.com]

It is characterised by rigidity (increased muscle tone), bradykinesia (slowing of movements) and tremors. [kenhub.com]

Affectation of which may result in bradykinesia or slow movements, lead-pipe rigidity, postural instability, mask like face, shuffling gait and resting tremor that are similar [healthfoxx.com]

Encephalitis Lethargica

rigidity and rest tremor), two had bradykinesia with postural instability, two had bradykinesia with rigidity, and two had bradykinesia with rest tremor. [doi.org]

Bradykinesia, rigidity Oculogyric crises, hemiballismus Mutism, disinhibition, compulsive touching Ophthalmoplegia, hiccough 10, F Hypersomnolence Present Bradykinesia – [doi.org]

Beta-Propeller Protein-Associated Neurodegeneration

Design/Methods: Examination revealed an alert, happy young woman with rigidity, dystonic posturing, and generalized bradykinesia. [neurology.org]

The group with predominant parkinsonism had characteristically bradykinesia, gait impairment, rigidity and altered postural reflexes. [mdsabstracts.org]

Parkinsonism can include unusually slow movement (bradykinesia), rigidity, tremors, an inability to hold the body upright and balanced (postural instability), and a shuffling [elbiruniblogspotcom.blogspot.no]

Huntington Disease-Like Type 3

Huntington’s Disease Clinical Features - 3 • juvenile onsetjuvenile onset • rigidity, dystonia, bradykinesia, myoclonusrigidity, dystonia, bradykinesia, myoclonus • seizuresseizures [slideshare.net]

[…] the extremities, which interferes with function.As the disease progresses, chorea coexists with ,and gradually is replaced by, dystonia and parkinsonian features, such as bradykinesia [physio-pedia.com]

This slowing of movements is called bradykinesia. Swallowing problems are common if you have HD. [patient.info]

Drug-Induced Dystonia

Parkinsonism Tremor, rigidity, mask-like facial expression, and/or bradykinesia Akathisia Restlessness and an internal feeling of unease Dystonia Abnormal tonic muscle contractions [pedemmorsels.com]

Parkinsonism and other medication-induced Parkinsonism Parkinsonian symptoms of mask-like facies, resting tremor, cogwheel rigidity, shuffling gait, and psychomotor retardation (bradykinesia [hopkinsguides.com]

[…] description RDP typically presents in childhood or early adulthood (but age of onset can range from 4-55 years) with the abrupt onset of dystonia along with parkinsonism (bradykinesia [orpha.net]

Huntington Disease-Like Type 1

This slowing of movements is called bradykinesia. Swallowing problems are common if you have HD. [patient.info]

[…] in offspring of an affected male Clinical Presentation Progressive neurodegenerative disorder Motor symptoms Tremor Chorea/choreoathetosis Slow ocular saccades Akinesia, bradykinesia [arupconsult.com]