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171 Possible Causes for Broad-Based Gait, Nystagmus

  • Acute Cerebellar Ataxia

    A 54-year-old woman with adenocarcinoma of the lung and lymph node metastasis experienced nystagmus and cerebellar ataxia 2 weeks after initiating nivolumab therapy.[ncbi.nlm.nih.gov] Horizontal nystagmus is present is approximately 50% of cases.[en.wikipedia.org] This patient developed symptoms of ACA, including nausea, vertigo, severe limb and truncal ataxia, and bilateral spontaneous continuous horizontal nystagmus with irregular[ncbi.nlm.nih.gov]

  • Friedreich Ataxia

    The unsteadiness further progresses to a broad-based,… Read More mitochondrial disorders In metabolic disease: Mitochondrial disorders …iron homeostasis is present in Friedreich[britannica.com] The clinical picture consisted of progressive spastic gait, truncal and limb ataxia, dysarthria, nystagmus, hyperreflexia with knee and ankle clonus and extensor plantar response[ncbi.nlm.nih.gov] Physical examination is notable for an ataxic gait, nystagmus, and mild dysarthria. You also observe the findings in Figure A on musculoskeletal examination.[step1.medbullets.com]

  • Ataxia Telangiectasia

    Abnormal ocular movements were seen in 13/15 (saccadic intrusion in 8 and nystagmus in 5).[ncbi.nlm.nih.gov] -year-old girl born to healthy parents showed manifestations suggestive of ataxia telangiectasia (AT), such as short stature, sudden short bouts of horizontal and rotary nystagmus[ncbi.nlm.nih.gov] Hypometric saccades were evident in 48 (76%), pursuit abnormalities in 43 (63%), and nystagmus in 18 (29%).[ncbi.nlm.nih.gov]

  • Ataxic Cerebral Palsy

    Patients with ataxic cerebral palsy will usually have a broad-based gait, i.e. they walk with their feet unusually far apart.[medhelp.org] The most common facial ataxic symptoms are jerky speech patterns and abnormal eye movements called nystagmus.[redbridgeserc.org] Showing of 9 Percent of people who have these symptoms is not available through HPO Autosomal recessive inheritance 0000007 Broad-based gait Wide based walk 0002136 Cerebellar[rarediseases.info.nih.gov]

  • Wernicke Encephalopathy

    In less severe cases, patients walk slowly with a broad-based gait. However, gait and stance may be so impaired as to make walking impossible.[emedicine.medscape.com] An examination revealed spontaneous upbeat nystagmus ( Video 1 ), gaze-evoked nystagmus ( Video 2 ), and gait ataxia. She had no ophthalmoplegia.[nejm.org] The classic triad of confusion, ophthalmoplegia (or nystagmus) and ataxia may be absent, and the history of alcohol abuse or other causes of thiamine deficiency may be unknown[ncbi.nlm.nih.gov]

  • Leigh's Disease

    A 21-year-old man with a longstanding history of impaired visual acuity, strabismus, broad-based gait, and below-average intellectual capacity developed respiratory difficulties[ncbi.nlm.nih.gov] The authors present the case of a 9-year-old girl with dorsal midbrain syndrome causing convergence retraction nystagmus.[ncbi.nlm.nih.gov] A 4 1/2-month-old girl suffered from psychomotor retardation, generalized hypotonia, poor feeding, hyperreflexia, nystagmus, optical atrophy and choreoathetosis from the age[ncbi.nlm.nih.gov]

  • Central Positional Vertigo

    In this case, the patient has a "sensory ataxia" with a broad-based gait.[dartmouth.edu] The first case had combined torsional and horizontal nystagmus to the right in a head-hanging position. The nystagmus lacked latency and did not diminish easily.[jstage.jst.go.jp] Persistent direction-changing positional nystagmus: another variant of benign positional nystagmus? Neurology. 1995 ; 45 : 1297–1301.[stroke.ahajournals.org]

  • Cerebellar Infarction

    .• Ataxia: broad-based stance and gait, Tandem walk is most sensitive.• Tremor: in volitional muscle contraction. – Positional postural action static (hands stretched out[slideshare.net] (SN) or direction changed bidirectional gaze-evoked nystagmus (GEN).[ncbi.nlm.nih.gov] To define the characteristics and mechanism of head-shaking nystagmus in central vestibulopathies, we investigated spontaneous nystagmus and head-shaking nystagmus in 72 patients[ncbi.nlm.nih.gov]

  • Alcoholic Cerebellar Degeneration

    Stance – a broad-based gait is noted in cerebellar disease 2.[geekymedics.com] […] degeneration has been observed in non-alcoholic patients with severe malnutrition. 5 Eye Movements Square Wave Jerks Horizontal Saccadic Hypermetria Horizontal Gaze Evoked Nystagmus[slideplayer.com] […] thiamine deficiency Alterations in GABA receptor dependent neurotransmission have also been proposed as a pathogenic mechanism Clinical features Truncal ataxia Unsteady gait Nystagmus[pathologyoutlines.com]

  • Subacute Combined Degeneration of Spinal Cord

    His gait was broad based with spinal ataxia. Decreased graphaesthesia was found on the lower limbs, the lower part of the trunk and on the upper limbs.[neuroanatomy.wisc.edu] Recovery from nystagmus and confusion is slower. Amnesia does not respond to treatment fully. Acute WKS: Mammillary body hemorrhages WKS, acute lesion.[neuropathologyweb.org] The classic clinical presentation of WE is a triad of eye abnormalities (nystagmus, oculomotor paralysis, paralysis of conjugate gaze), ataxia of stance and gait, and mental[neuropathologyweb.org]

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