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1,087 Possible Causes for Broad Nasal Bridge, Brushfield Spots, Wide Space Between the First and Second Toe

  • Down Syndrome

    bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21 — called also trisomy 21 First Known Use of Down syndrome[merriam-webster.com] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] Brushfield's spots: Speckled iris. Little white spots that slightly elevated on the surface of the iris arranged in a ring concentric with the pupil.[medterms.com]

  • Dubowitz Syndrome

    nasal bridge, dysplastic auricles, and retrognathia, is presented.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The features include: a small, narrow and asymmetrical face; a high, broad and sloping forehead; widely spaced eyes; broad nasal bridge; and short, webbed neck.[cafamily.org.uk]

    Missing: Brushfield Spots
  • Zellweger Syndrome

    bridge Broad nasal bridge Broad nasal root Broadened nasal bridge Increased breadth of bridge of nose Increased breadth of nasal bridge Increased width of bridge of nose[rarediseases.info.nih.gov] We did not observe any Brushfield spots, any renal and brain cysts, or adrenal insufficiency.[ncbi.nlm.nih.gov] Clinical Features [ edit ] Craniofacial Features Flat occiput and face Anteverted nares Epicanthal folds Brushfield spots High forehead Large fontanels Shallow orbits Ocular[en.wikibooks.org]

    Missing: Wide Space Between the First and Second Toe
  • Ring Chromosome 10

    bridge Broad nasal bridge Broad nasal root Broadened nasal bridge Increased breadth of bridge of nose Increased breadth of nasal bridge Increased width of bridge of nose[rarediseases.info.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Increased width of nasal bridge Nasal bridge broad Wide bridge of nose Widened nasal bridge [ more ] 0000431 Showing of 24 Last updated: 3/1/2019 Support and advocacy groups[rarediseases.info.nih.gov]

    Missing: Brushfield Spots
  • Smith-Magenis Syndrome

    Both conditions share brachycephaly, upward slanting palpebral fissures, a short and broad nose, a round face with midface flattening, iris hamartomas (Brushfield spots in[jmg.bmj.com] The common clinical findings were: speech delay with behavioural problems associated with broad flat midface, brachycephaly, broad nasal bridge and brachydactyly.[ncbi.nlm.nih.gov] The main clinical features consist of a broad flat midface with brachycefaly, broad nasal bridge, brachydactily, speech delay, hoarse deep voice and peripheral neuropathy.[ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Baraitser-Winter Syndrome 1

    Her facial anomalies included high arched eyebrows, hypertelorism, downslanted palpebral fissures, a broad nasal bridge, a broad nasal tip and columella, anteverted nostrils[ncbi.nlm.nih.gov] spots, upslanting palpebral fissures, epicanthal folds Most cases not inherited Trisomy 21 (most cases), translocation, mosaic #190685 DOYNE HONEYCOMB DYSTROPHY (MALATTIA[eyewiki.aao.org] Facial dysmorphism included high arched eyebrows, proptosis, hypertelorism, downslanted palpebral fissures, broad nasal bridge, broad nasal tip and columella, anteverted nostrils[ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Acro-Fronto-Facio-Nasal Dysostosis

    The three sibs suffered from marked hypertelorism, downslanting palpebral fissures, ptosis of eyelids, broad nasal bridge and tip with midline groove, dysmorphic pinna, variable[cags.org.ae] spots Brachydactyly Anonychia Cerebral cortical atrophy Micromelia ... ...[familydiagnosis.com] […] mouth Large mouth [ more ] 0000154 Wide nasal bridge Broad nasal bridge Broad nasal root Broadened nasal bridge Increased breadth of bridge of nose Increased breadth of nasal[rarediseases.info.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Familial Congenital Nasolacrimal Duct Obstruction

    […] flat nasal bridge, malformed ears, and short neck.[genome.jp] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] Associated features include generalized hypotonia, transverse palmar creases (simian lines),shortening and incurving of the 5th fingers (clinodactyly),Brushfield's spots and[quizlet.com]

  • Hypertelorism

    Clinical description Craniofacial manifestations include wide anterior fontanel, flat occiput, hypertelorism, ptosis, proptosis, broad nasal bridge and nasal tip, long philtrum[orpha.net] Down21 - non-disjunction causing trisomy 21; or Robertsonian translocation (14;21)Epicanthic folds; flat nasal bridge; protruding tongue; Brushfield spots; increased space[dontforgetthebubbles.com] […] eyebrows, long palpebral fissures, ptosis, high and broad nasal bridge, short nose, low-set ears, natal teeth, thin upper lip and a grooved chin, as well as limb (i.e. fifth-finger[orpha.net]

    Missing: Wide Space Between the First and Second Toe
  • Adactyly of Foot

    Cri du Chat ( 5p-) Clinical Presentation 1:50,000 Hypertelorism Broad nasal bridge Cleft lip /- palate Severe MR 65% Seizures 50-100% Heart defects 50% 1:20,000 to 1:50,000[quizlet.com] spots, 89 hamartomata, 24 isolated congenital nail dysplasia, 469 J Jackson-Weiss syndrome, 209 Jadassohn nevus phakomatosis, 366 joint ankylosis, 59 contracture, 59 hypermobility[docplayer.net] , flat nasal bridge; and widely spaced eyes (hypertelorism).Abnormalities of the digits can affect both the fingers and the toes in people with oral-facial-digital syndrome[ncbi.nlm.nih.gov]

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