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21 Possible Causes for Broad Nasal Bridge, Delayed Speech Development, Wide Space Between the First and Second Toe

  • Down Syndrome

    bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21 — called also trisomy 21 First Known Use of Down syndrome[merriam-webster.com] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] , particularly those with the greatest delays in speech and language development.[dseinternational.org]

  • Dubowitz Syndrome

    nasal bridge, dysplastic auricles, and retrognathia, is presented.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The features include: a small, narrow and asymmetrical face; a high, broad and sloping forehead; widely spaced eyes; broad nasal bridge; and short, webbed neck.[cafamily.org.uk]

  • Ring Chromosome 10

    bridge Broad nasal bridge Broad nasal root Broadened nasal bridge Increased breadth of bridge of nose Increased breadth of nasal bridge Increased width of bridge of nose[rarediseases.info.nih.gov] She had slight delay in psychomotor development, including speech delay. She could sit at the age of 9 months, and walk unsupported at the age of 12 months.[omicsonline.org] Schmidt et al. (1981) reported a 35-month-old girl of Puerto Rican descent with delayed psychomotor development, poor speech, and dysmorphic features, including high forehead[omim.org]

  • Short Stature due to Endocrine Disorder

    bridge Broad nasal bridge Broad nasal root Broadened nasal bridge Increased breadth of bridge of nose Increased breadth of nasal bridge Increased width of bridge of nose[rarediseases.info.nih.gov] Delayed speech and language development MedGen UID: 105318 • Concept ID: C0454644 • Finding A degree of language development that is significantly below the norm for a child[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Kleiner Holmes Syndrome

    bridge; Choanal stenosis or atresia; Strabismus; Narrow palate; Cleft palate; Bifid uvula; Malocclusion; Delayed dental eruption; Ventricular septal defect; Overriding aorta[panelapp.genomicsengland.co.uk] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] speech and language development Esophageal carcinoma Clinodactyly of the 5th toe Abnormality of the voice Chest pain Cough Nausea and vomiting Lymphadenopathy Kyphoscoliosis[mendelian.co]

  • Cutis Laxa

    nasal bridge Large forehead Wideset eyes Anterverted nares (upturned nose) Low-set ears The photograph at the top right of this page shows a young child with cutis laxa type[forgottendiseases.org] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] Consanguinity Delayed speech with poor language development Hypertelorism Depressed flat nasal bridge High palate Cutis laxa Small atrial septal defect Table 1: Presenting[medical-case-reports.imedpub.com]

  • Baraitser Syndrome

    nasal bridge, and epicanthic folds.[pediatricneurosciences.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Nearly half of affected individuals experience severe developmental delay / intellectual disability (ID) with particular delays in speech and language development.[ncbi.nlm.nih.gov]

  • Weaver Syndrome

    nasal bridge, accentuated philtrum, micrognathia and large ears, and unique behavior characteristics with some social withdrawal.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] She has a facial appearance similar to that of her son, with a round face, depressed nasal bridge, and broad nasal tip (fig 3 ).[jmg.bmj.com]

  • Familial Congenital Nasolacrimal Duct Obstruction

    […] flat nasal bridge, malformed ears, and short neck.[genome.jp] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] The same can be said about the delay in speech development.[e-aps.org]

  • Genee-Wiedemann Syndrome

    Clinical: Clefts and fibroma of tongue; polydactylia; broad nasal bridge; narrow-arched palate ; short humerus, femur, and tibia; irregular teeth; hypotonia; mental retardation[dentisty.org] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] Miller syndrome does not affect a person's intelligence, although speech development may be delayed due to hearing impairment.[ghr.nlm.nih.gov]

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