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373 Possible Causes for Broad Nasal Bridge, Epicanthal Folds

  • Down Syndrome

    folds, flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21 — called also Down, Down's, trisomy[merriam-webster.com] In 1876 he specifically identified the fold of skin at the inner corner of the eyes which he described as epicanthic folds and he also noted that the ear was usually placed[intellectualdisability.info] In the postnatal period, characteristic phenotypical features point to the diagnosis: depressed nasal bridge epicanthic folds abundant neck skin macroglossia simian crease[radiopaedia.org]

  • Pallister-Killian Syndrome

    Patients also exhibit a distinctive facial structure, characterized by high foreheads, sparse hair on the temple, a wide space between the eyes, epicanthal folds and a flat[en.wikipedia.org] nasal bridge, short nose with upturned nares, large mouth with downturned corners and prominent upper lip.[orpha.net] folds large ears with lobes that are thick and protrude outward.[en.wikibooks.org]

  • Homocystinuria

    The patient also shows signs that had not been previously described: epicanthal folds, broad nasal bridge, long and flat philtrum, amimic expression and, particularly, a postural[ncbi.nlm.nih.gov] The patient also shows signs that had not been previously described: epicanthal folds, broad nasal bridge, long and flat philtrum, amimic expression and, particularly, a postural[ncbi.nlm.nih.gov]

  • Dubowitz Syndrome

    Ocular problems occur in about 20%: strabismus, blefarophimosis, ptosis, telecanthus and epicanthal folds being the most frequent ones.[ncbi.nlm.nih.gov] nasal bridge, dysplastic auricles, and retrognathia, is presented.[ncbi.nlm.nih.gov] Dubowitz syndrome is an autosomal recessive condition characterized by pre- and postnatal growth retardation, eczema, telecanthus, epicanthal folds, blepharophimosis, ptosis[ncbi.nlm.nih.gov]

  • Jacobsen Syndrome

    Clinical features included growth and mental retardation, hypotonia, trigonocephaly, facial dysmorphism with hypertelorism, epicanthal folds, abnormally shaped palpebral fissures[ncbi.nlm.nih.gov] nasal bridge, short nose, v-shaped mouth, small ears, low set posteriorly rotated ears).[ncbi.nlm.nih.gov] Facial dysmorphism was also common and included hypertelorism, epicanthal folds, and down-slanting palpebral fissures.[ncbi.nlm.nih.gov]

  • Hypertrichotic Osteochondrodysplasia

    Some features are suggestive of a storage disorder, including macrocephaly and coarse facial features, with a broad nasal bridge, epicanthal folds, wide mouth, and full lips[diseaseinfosearch.org] Clinical description Dysmorphic features include macrocephaly and a coarse facial appearance with thick eyebrows, prominent supraorbital ridges, broad nasal bridge, anteverted[orpha.net] In addition, macrocephaly and coarse facial features, including a broad nasal bridge, epicanthal folds, a wide mouth, and full lips, can be suggestive of a storage disorder[uniprot.org]

  • Blepharophimosis-Epicanthus Inversus-Ptosis Syndrome

    fold and if these folds are nasal (most commonly are) they will cause telecanthus. [ citation needed ] Fig of the used terms References [ edit ][en.wikipedia.org] bridge Broad nasal bridge Broad nasal root Broadened nasal bridge Increased breadth of bridge of nose Increased breadth of nasal bridge Increased width of bridge of nose[rarediseases.info.nih.gov] If the epicanthal folds are small, a "Y-V canthoplasty" is traditionally used; if the epicanthal folds are severe, a "double Z-plasty" is used.[rarediseases.info.nih.gov]

  • Fetal Hydantoin Syndrome

    Physical findings included gum hypertrophy, digitalization of the thumbs, hypoplasia of the distal phalanges and nails, epicanthal folds, pseudohypertelorism, epidermoid cyst[ncbi.nlm.nih.gov] Phenytoin is associated with fetal hydantoin syndrome, typified by changes in the finger tips, hypoplasia of nails, a broad nasal bridge, a wide distance between the eyes,[acronymfinder.com] […] over the inside corner of the eye (called an epicanthal fold).[thinkgenetic.com]

  • Baraitser-Winter Syndrome 1

    Clinical Characteristics Ocular Features: Ptosis (both unilateral and bilateral), hypertelorism, prominent epicanthal folds, and colobomata are common.[disorders.eyes.arizona.edu] Her facial anomalies included high arched eyebrows, hypertelorism, downslanted palpebral fissures, a broad nasal bridge, a broad nasal tip and columella, anteverted nostrils[ncbi.nlm.nih.gov] Other clinical features included: strabism, epicanthic folds, broad nasal bridge, and brain anomalies such as lissencephaly, bilateral hygroma and cerebral atrophy.[endocrine-abstracts.org]

  • Neuhauser Syndrome

    They also had hypotonia, incomplete cleft palate, bifid uvula, depressed nasal bridge, epicanthal folds, hypoplastic labia major, micrognathia and pectus excavatum.[ncbi.nlm.nih.gov] nasal bridge, epicanthus), who also had additional findings such as Peters' anomaly, microcephaly, undescended testicle, patent ductus arteriosus and atrial septal defects[ncbi.nlm.nih.gov] folds, broad nasal root, frontal bossing and antimongoloid lid slanting.[disorders.eyes.arizona.edu]

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