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24 Possible Causes for Broad Nasal Bridge, Myopia, Wide Space Between the First and Second Toe

  • Down Syndrome

    bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21 — called also trisomy 21 First Known Use of Down syndrome[merriam-webster.com] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] Nystagmus was related to myopia and esotropia, and to heart disease and heart operations.[oadoi.org]

  • Dubowitz Syndrome

    nasal bridge, dysplastic auricles, and retrognathia, is presented.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] […] eruption of teeth Dry skin High palate Hydrocephalus Hydronephrosis Hypoparathyroidism Hypoplastic toenails Joint hyperflexibility Lymphoma Malabsorption Metatarsus adductus Myopia[dovemed.com]

  • Ring Chromosome 10

    bridge Broad nasal bridge Broad nasal root Broadened nasal bridge Increased breadth of bridge of nose Increased breadth of nasal bridge Increased width of bridge of nose[rarediseases.info.nih.gov] Patient III . 14 year-old boy, short stature, dolico-trigonocephaly, bilateral epicanthic folds, upslanting palpebral fissures, ocular hypertelorism, left palpebral ptosis, myopia[biomedsearch.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Short Stature due to Endocrine Disorder

    bridge Broad nasal bridge Broad nasal root Broadened nasal bridge Increased breadth of bridge of nose Increased breadth of nasal bridge Increased width of bridge of nose[rarediseases.info.nih.gov] 0001943 Low anterior hairline Low frontal hairline Low-set frontal hairline [ more ] 0000294 Low posterior hairline Low hairline at back of neck 0002162 Motor delay 0001270 Myopia[rarediseases.info.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Atelosteogenesis Type 2

    Note dysplasia, scaphocephalic macrocephaly, coarse facial features, depressed nasal bridge, broad nasal tip, thick lips, short neck, protuberant abdomen, inguinal hernia,[thehealthscience.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] A consanguineous Saudi family with severe and recurrent large joint dislocation and severe myopia, was identified with a homozygous truncating variant in GZF1.[rarediseases.org]

  • Cutis Laxa

    nasal bridge Large forehead Wideset eyes Anterverted nares (upturned nose) Low-set ears The photograph at the top right of this page shows a young child with cutis laxa type[forgottendiseases.org] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] Features include inelastic skin which sags and may be wrinkly, high myopia, arterial tortuosity, aneurysms, stenosis, joint laxity and arachnodactyly among other clinical[unmc.edu]

  • Kleiner Holmes Syndrome

    bridge; Choanal stenosis or atresia; Strabismus; Narrow palate; Cleft palate; Bifid uvula; Malocclusion; Delayed dental eruption; Ventricular septal defect; Overriding aorta[panelapp.genomicsengland.co.uk] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov] […] and Distinctive Facial Features cleft palate-lateral synechia syndrome cleft soft palate Cleidorhizomelic Syndrome CLOVES syndrome COACH Syndrome Cochlear Deafness with Myopia[rgd.mcw.edu]

  • Familial Congenital Nasolacrimal Duct Obstruction

    […] flat nasal bridge, malformed ears, and short neck.[genome.jp] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] Corneal enlargement Axial myopia Hereditary megalocornea Keratoglobus 3.[entokey.com]

  • Baraitser Syndrome

    nasal bridge, and epicanthic folds.[pediatricneurosciences.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Visual deficits including myopia and astigmatism have been seen in ten and four affected individuals, respectively.[ncbi.nlm.nih.gov]

  • Adactyly of Foot

    Cri du Chat ( 5p-) Clinical Presentation 1:50,000 Hypertelorism Broad nasal bridge Cleft lip /- palate Severe MR 65% Seizures 50-100% Heart defects 50% 1:20,000 to 1:50,000[quizlet.com] Severe myopia (-8 diopters), shortness of the neck and torticollis have been found and was investigated accordingly (Figures 4, 5, 6 ).[ojrd.biomedcentral.com] , flat nasal bridge; and widely spaced eyes (hypertelorism).Abnormalities of the digits can affect both the fingers and the toes in people with oral-facial-digital syndrome[ncbi.nlm.nih.gov]

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