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57 Possible Causes for bromodeoxyuridine, triphosphate

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  • Zidovudine

    "Induction of endogenous virus and of thymidine kinase by bromodeoxyuridine in cell cultures transformed by Friend virus".[en.wikipedia.org] In the present study, the potential role of inosine triphosphate pyrophosphatase (ITPA) gene variant on the incidence of adverse events during antiretroviral therapy (ART)[ncbi.nlm.nih.gov] […] chromatography-tandem mass spectrometry (LC-MS/MS) for measurement of intracellular concentrations of zidovudine (AZT)-monophosphate (AZT-MP), -diphosphate (AZT-DP) and -triphosphate[ncbi.nlm.nih.gov]

  • Antimetabolite

    The results of the analyses showed upregulation of pathways related to DNA repair along with NA incorporation (bromodeoxyuridine uptake) and elevation of %CD133( ) cells in[ncbi.nlm.nih.gov] Decreased endogenous 2'-deoxynucleoside-5'-triphosphate (dNTP) pools result in a better competition of the NRTI (as its triphosphate derivative), with the dNTPs for the virus-encoded[ncbi.nlm.nih.gov] .  Ara-CTP triphosphate is the cytotoxic metabolite.[slideshare.net]

  • Cytarabine

    Uridine and its analogs, 3-deazauridine, 5-bromodeoxyuridine, 5-fluorodeoxyuridine and 6-azauridine, were found to competitively inhibit cytidine deaminase; the most potent[ncbi.nlm.nih.gov] SAMHD1 is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase that cleaves physiological dNTPs into deoxyribonucleosides and inorganic triphosphate.[ncbi.nlm.nih.gov] The cationic nature of PPI dendrimers makes it possible to form complexes with nucleotide Ara-C triphosphate forms (Ara-CTP).[ncbi.nlm.nih.gov]

  • Pentasomy X

    […] molecular findings provided evidence that more than one active X chromosome was likely to be present in the cells of this patient, accounting for her abnormal phenotype. 5-bromodeoxyuridine[ncbi.nlm.nih.gov] The kit also contains deoxynucleotide triphosphates (dNTPs) and Hot Start Taq DNA polymerase in an optimized reaction buffer.[ncbi.nlm.nih.gov] Results: 5-bromodeoxyuridine (BrdU)-pulsed cultures showed different patterns among late replicating X chromosomes suggesting that their replication was asynchronic and likely[arca.fiocruz.br]

  • Chromosome Aberration

    Abstract The thymidine analogue, 5'-bromodeoxyuridine (BrdU), is a known mutagen that is routinely introduced into culture media for subsequent Harlequin stain analysis and[ncbi.nlm.nih.gov] […] density gradient and, to induce PCC, are incubated at 37 degrees C in cell culture medium supplemented with a phosphatase inhibitor (okadaic acid or calyculin A), adenosine triphosphate[ncbi.nlm.nih.gov]

  • Dihydropyrimidinuria

    […] combined with fluorescence in situ suppression hybridization and replicated prometaphase R-bands, which is based on cell synchronization with excess thymidine followed by bromodeoxyuridine[osti.gov] […] and cytidine triphosphate (CTP).[ommbid.mhmedical.com] Ca pyrophosphate arthropathy (chondrocalcinosis-2; 118600) Increased nucleoside triphosphate pyrophosphohydrolase ANKH (5p15.2-p14.1)* Biochemical profile: Ca pyrophosphate[merckmanuals.com]

  • Marburg Virus Disease

    The agent was completely resistant to the effects of the metabolic inhibitor 5-bromodeoxyuridine, which may mean that RNA is the genetic material.[ncbi.nlm.nih.gov] In addition, there is a putative ATP and/or purine ribonucleoside triphosphate binding domain found in all known L proteins of single-strand negative-sense viruses (amino[doi.org]

  • Bloom Syndrome

    Detection of SCEs typically requires cells to incorporate bromodeoxyuridine (BrdU) during two rounds of DNA synthesis.[ncbi.nlm.nih.gov] The reactions are dependent on nucleoside triphosphate hydrolysis and require a free 3' tail attached to the third strand.[ncbi.nlm.nih.gov] […] the high levels of sister-chromatid exchanges that are the hallmark of BS cells occur primarily as a result of replication proceeding on a template that has incorporated bromodeoxyuridine[doi.org]

  • Alkylating Agent

    Among them, BO-1090, bis(hydroxymethyl)-3a-aza-cyclopenta[a]indene derivative, targeted DNA for its cytotoxic effects as shown by inhibition of DNA synthesis (bromodeoxyuridine-based[ncbi.nlm.nih.gov] DUT-N is one of the two isoforms of deoxyuridine triphosphate nucleotidohydrolase (dUTPase). Our current knowledge of DUT-N expression in human cells is very limited.[ncbi.nlm.nih.gov] […] basal cell carcinomas adverse effects of 5-FUBM supp, GI tract toxicity list 3 pyrimidine analogs5- fluorouracil, cytarabine, gemcitabine MOA of cytarabineconverted to a triphosphate[memorize.com]

  • Malignant Glioma

    Abstract Since July 1985, 23 patients have been entered into a phase I/II clinical trial using intraarterial 5-bromodeoxyuridine (BUdR) (400-600 mg/m2 daily for 8.5 weeks)[ncbi.nlm.nih.gov] […] mitochondrial dysfunction was detected in the Adpa‑Mn‑treated group, including disrupted membrane potential, elevated levels of reactive oxygen species (ROS) and depleted adenosine triphosphate[ncbi.nlm.nih.gov] After this study, the NCOG initiated a phase II trial using bromodeoxyuridine (BUdR) given during radiation therapy, followed by PCV chemotherapy.[jco.ascopubs.org]

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