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57 Possible Causes for Brushfield Spot, Leukemia, Short Broad Feet

  • Down Syndrome

    (AMKL) and 20 times more likely to develop acute lymphoblastic leukemia (ALL) than typical children.[ncbi.nlm.nih.gov] Brushfield's spots: Speckled iris. Little white spots that slightly elevated on the surface of the iris arranged in a ring concentric with the pupil.[medterms.com] Short little finger. In-curved little finger. Short broad hands. Feet: Gap between hallux and second toes. Congenital heart defects. Duodenal atresia.[patient.info]

  • Oculopalatoskeletal Syndrome

    In patients who are reluctant to undergo splenectomy 28 and/or in those with an underlying condition (SLE, common variable immunodeficiency, chronic lymphocytic leukemia)[bloodjournal.org] spots Fraser’s syndrome (219000) Cryptophthalmos, malformed lacrimal ducts, hypertelorism, blindness Glucose transport defect (606777) Abnormal paroxysmal eye movements;[clinicalgate.com] She had low set ears, broad hands, short fingers, and short broad feet [Figure 3] a-c. Figure 3: The features of Michels syndrome.[ijo.in]

  • Absent Thumb - Short Stature - Immunodeficiency Syndrome

    […] and gliomas, as well as the exceedingly rare juvenile myelomonocytic leukemia and choroid plexus carcinomas.[hematology.org] spots Term Definition AD, TSC1/2 gene ash-leaf/hypopigmented macules, shagreen patch, facial angioma/adeoma sebaceum, ungual fibromas, seizures/infantile spasms, cardiac[flashcardmachine.com] […] nose, narrow nares, large lips, short neck, widely spaced nipples, puffy hand and feet, dark pigmented naevi, caf -au-lait spots, microcephaly, growth delay, speech delay[chr7.org]

  • Ring Chromosome 21

    This report describes a case of acute lymphoblastic leukemia with non-B, non-T, common acute lymphocytic leukemia antigen-positive blasts in a 13-year-old child with constitutional[ncbi.nlm.nih.gov] Ring of iris speckles - Brushfield's spots. Ears set low, folded or stenotic meatus. Flat nasal bridge. Mouth: Protruding tongue (small narrow palate).[patient.info] Similarly, other signs not present in TY and LI but present in AL, such as Brushfield spots, abnormal teeth, joint hyperlaxity, and ventricular septal defect (table 17, are[publications.fondationlejeune.org]

  • Monosomy 21q

    Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype . Leukemia 2008; 22 : 1539–1541. 18.[nature.com] Similarly, other signs not present in TY and LI but present in AL, such as Brushfield spots, abnormal teeth, joint hyperlaxity, and ventricular septal defect (table 17, are[publications.fondationlejeune.org] The patient may have an extremely prominent forehead (frontal bossing), enlargement of the back part of the head, low placement of ears, short broad hands and feet, unusually[rarediseases.org]

  • Partial Trisomy 21 in Down Syndrome

    Keywords Imatinib Chronic Myeloid Leukemia Blast Crisis Derivative Chromosome Chronic Phase Chronic Myeloid Leukemia Background Chronic myeloid leukemia (CML) is a clonal[molecularcytogenetics.biomedcentral.com] Brushfield spots may be observed in the iris.[symptoma.com] Short little finger. In-curved little finger. Short broad hands. Feet: Gap between hallux and second toes. Congenital heart defects. Duodenal atresia.[patient.info]

  • Trisomy 9

    Here we present the case history of a patient with the clinical diagnosis of secondary acute myelogenous leukemia whose bone marrow cells were found to be hyperdiploid with[ncbi.nlm.nih.gov] Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, brushfield spots on the iris, protruding tongue, small[icd9data.com] , short neck, overlapping fingers, rocker-bottom feet, prominent heels, and hypoplastic toenails.[ncbi.nlm.nih.gov]

  • Disproportionate Short Stature - Ptosis - Valvular Heart Lesions

    Medical genetics, pediatrics Symptoms Mildly unusual facial features, short height, congenital heart disease, bleeding problems, skeletal malformations [1] Complications Leukemia[en.wikipedia.org] Brushfield spots (gray to white spots resembling grains of salt around the periphery of the iris) may be visible.[merckmanuals.com] The pupils may have light smudgy opaque Brushfield spots.[hawaii.edu]

  • Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome

    As a result, certain white blood cells are overproduced, leading to this type of leukemia. JMML may regress spontaneously or evolve in acute myeloid leukemia .[flipper.diff.org] The pupils may have light smudgy opaque Brushfield spots.[hawaii.edu] […] hands with broad thin fingers and elongated thumbs, a mild talipes calcaneovalgus deformity of the feet, small VSD, psychomotor retardation p15 489013, 3874588, 4043965,[chr7.org]

  • Acro-Fronto-Facio-Nasal Dysostosis

    leukemia Acute lymphocytic leukemia Acute m-Acute r Acute megakaryoblastic leukemia Acute monoblastic leukemia Acute mountain sickness Acute myeloblastic leukemia type 1[statemaster.com] spots Brachydactyly Anonychia Cerebral cortical atrophy Micromelia ... ...[familydiagnosis.com] Acrofrontofacionasal dysostosis I: Mental retardation, short stature, hypertelorism with eye anomalies, broad notched nasal tip, cleft lip/palate, postaxial camptobrachypolysyndactyly[accessanesthesiology.mhmedical.com]

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