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104 Possible Causes for Buffalo Hump, Polycystic Ovary Syndrome

  • Endocrine Dysfunction

    Metformin is a widely used and extensively studied insulin sensitising drug for the treatment of women with polycystic ovary syndrome (PCOS), with various actions in tissues[ncbi.nlm.nih.gov] Key features are central fat deposition resulting in a moon face, fat deposition over the clavicles and upper spine ("buffalo hump") and around the abdomen with production[diapedia.org] (too active) Addison’s disease (not active enough) Pheochromocytomas (tumors) Ovaries (produce estrogen and progesterone in women) Ovarian cysts and polycystic ovary syndrome[houstonmethodist.org]

  • Cushing's Disease

    The UFC test has a specificity of 81% and thus has a high rate of false-positives that are due to pseudo-Cushing states, sleep apnea, polycystic ovary syndrome, familial glucocorticoid[en.wikipedia.org] In addition to the typical clinical symptoms such as moon face,buffalo hump,and central obesity,the CD patients may also experience mental disorders and cognitive dysfunction[ncbi.nlm.nih.gov] Cushing’s syndrome may be mistaken for other conditions that have many of the same signs, such as polycystic ovary syndrome or metabolic syndrome .[niddk.nih.gov]

  • Lipodystrophy

    Some patients may display the features of polycystic ovary syndrome such as hirsutism, oligomenorrhea, polycystic ovaries and infertility.[orpha.net] It can manifest as a loss of fat in legs, arms, face or buttocks or even by an accumulation of fat in the belly, on breasts/chest or at the nape of the neck (buffalo hump)[hug-ge.ch] After puberty, some women with FPL may develop polycystic ovary syndrome (PCOS), a complex of symptoms that are not always present in every case.[rarediseases.org]

  • Obesity

    Polycystic ovary syndrome (PCOS) .[kidshealth.org] Polycystic ovary syndrome .[patient.info] These include: polycystic ovary syndrome (PCOS) : a condition that causes an imbalance of female reproductive hormones Prader-Willi syndrome: a rare condition that an individual[healthline.com]

  • Generalized Lipodystrophy

    ovary syndrome.[symptoma.com] hump[glosbe.com] After puberty, some women with CGL may develop polycystic ovary syndrome (PCOS). PCOS is characterized by an imbalance of female sex hormones.[rarediseases.org]

  • Familial Partial Lipodystrophy

    According to current diagnostic criteria, polycystic ovary syndrome (PCOS) is effective as a diagnosis of exclusion.[ncbi.nlm.nih.gov] A “ buffalo hump ” can be observed between the shoulder blades. The arms and legs appear very muscular. In women, lack of fat in the buttocks is striking — flat hips .[manbironline.com] Discussion Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 4–8% of women in reproductive age [5].[journals.viamedica.pl]

  • Adrenocortical Carcinoma

    Mitotane seems to be the drug of choice in Cushing's disease associated with polycystic ovary syndrome because it does not stimulate androgen production as other inhibitors[scielo.br] Symptoms of increased cortisol or other adrenal gland hormones may include: Fatty, rounded hump high on the back just below the neck ( buffalo hump ) Flushed, rounded face[nlm.nih.gov] Symptoms Symptoms of increased cortisol or other adrenal gland hormones may include: Fatty, rounded hump high on the back just below the neck ( buffalo hump ) Flushed, rounded[ufhealth.org]

  • Pediatric Hypertension

    Other causes include Takayasu arteritis, Henoch-Schonlein purpura, polycystic ovary syndrome, increased intracranial pressure, dysautonomia, Guillan-Barre’ syndrome, mid aortic[symptoma.com] Moon facies, truncal obesity, buffalo hump (Thyromegaly, Proptosis, hyperdynamic circulation…….. (Hyperthyroidism Signs of meningeal irritation,…………………… CNS Infections.[slideshare.net] , pseudohypoaldosteronism type 2, congenital adrenal hyperplasia and syndrome of apparent mineralocorticoid excess) or renal parenchymal or vascular abnormalities.[symptoma.com]

  • Anterior Pituitary Disease

    ovary syndrome, precocious puberty Infertility, amenorrhea, decreased libido (males) Prolactin Infertility, amenorrhea, decreased libido (males) Inability to lactate Further[clinicaladvisor.com] Cushings sydrome is the clinical syndrome with features of prolonged high glucocorticoid levels, ie: Central obesity, buffalo hump, round face Striae, thinning and bruising[anaesthesia.med.usyd.edu.au] There is a characteristic appearance in many patients with Cushing's disease which includes a round face, excess fat pad in the back of the neck ("buffalo hump"), excess fat[emoryhealthcare.org]

  • Endometrial Hyperplasia

    To explore the possible significance of aromatase P450 in endometrial hyperplasia with a background of polycystic ovary syndrome (PCOS).[ncbi.nlm.nih.gov] The patient's striae, weight gain, and buffalo hump markedly improved, and further bone loss was halted.[ncbi.nlm.nih.gov] Polycystic ovary syndrome (PCOS) and endometrial hyperplasia (EH), which are associated with increased risk of endometrial carcinoma, have been identified as potentially new[ncbi.nlm.nih.gov]

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