Bulbar Involvement: Causes & Reasons

Possible Causes for Bulbar Involvement

Infantile-Onset Ascending Hereditary Spastic Paralysis

Infantile-onset ascending hereditary spastic paraplegia with bulbar involvement due to the novel... [deepdyve.com]

He also developed bulbar involvement and severe scoliosis during childhood. [ncbi.nlm.nih.gov]

Progressive Bulbar Paralysis

In most cases the early symptoms are connected with bulbar involvement. [wikilectures.eu]

PBP, mixed bulbar palsy and pseudo-bulbar palsy involve the muscles of speech and swallowing. [mndcare.net.au]

[…] is a term reserved for involvement only of the bulbar muscles in MND. [leedsth.nhs.uk]

Upper Motor Neuron Disease

There are different types of MND - e.g. with predominantly upper motorneuron involvement, with predominantly lower motorneuron involvement or with mainly bulbar involvement [neurological.org.nz]

[…] cause UMN symptoms and signs such as spasticity, weakness and hyperreflexia where the progressive bulbar involvement causes bulbar symptoms such as dysarthria and dysphagia [explainmedicine.com]

PBP, mixed bulbar palsy and pseudo-bulbar palsy involve the muscles of speech and swallowing. [mndcare.net.au]

Late-Onset Pompe Disease

Oropharyngeal dysphagia may occur in late-onset Pompe disease, implicating bulbar muscle involvement. Neuromuscul Disord 2013; 23: 319-23. 147. [medicinabuenosaires.com]

Oropharyngeal dysphagia may occur in late-onset Pompe disease, implicating bulbar muscle involvement. [ncbi.nlm.nih.gov]

Adult-onset acid maltase deficiency with prominent bulbar involvement and ptosis. J R Soc Med. 1993;86:50. [PMC free article] [PubMed] [Google Scholar] 31. Amato AA. [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 4

Bulbar involvement is often mild and occurs late in the disease. [neuroweb.us]

(4) presence versus absence of bulbar involvement. [jnnp.bmj.com]

Fazio-Londe Disease

Involvement of extraocular movements is usually rare. Bulbar impairment is indicated by dysarthria, dysphagia and facial diplegia. [ncbi.nlm.nih.gov]

In about 25 percent of ALS patients early symptoms begin with bulbar involvement. Some 75 percent of patients with classic ALS eventually show some bulbar involvement. [motor-neuron.com]

Diagnosis of a variant of Spinal Muscular Atrophy was considered as the bulbar involvement was more prominent than proximal muscle weakness. [ncbi.nlm.nih.gov]

Spinal and Bulbar Muscular Atrophy

involvement. [ncbi.nlm.nih.gov]

contraction fasciculations, and bulbar involvement. [ncbi.nlm.nih.gov]

BACKGROUND: Dysphagia due to bulbar involvement is a major symptom of patients with spinal and bulbar muscular atrophy (SBMA). [ncbi.nlm.nih.gov]

Bulbar Poliomyelitis

This implies that bulbar involvement is the sole cause of respiratory inadequacy in patients with poliomyelitis. [jamanetwork.com]

Since rational therapy must depend on the type of bulbar involvement. .. [nejm.org]

New dysphagia was more severe in patients with previous bulbar involvement, implying an earlier exhaustion of the already overtaxed remaining bulbar motor neurons. [nejm.org]

Lower Motor Neuron Syndrome with Late-Adult Onset

Bulbar involvement is often mild and occurs late in the disease. [neuroweb.us]

Because of the prominent bulbar involvement, Kennedy’s disease can be difficult to differentiate from the bulbar variant of ALS. [neupsykey.com]

Amyotrophic Lateral Sclerosis Type 11

The beginning of symptoms was weakness in upper limbs, without involvement of lower limbs or bulbar functions. [intechopen.com]

involvement resulting in dysartheria and/or dysphagia. 5-15% of ALS cases patients present with bulbar or spinal neurodegeneration and dementia; 5% present with bulbar only [preventiongenetics.com]

Eventually though, affected individuals lose muscle strength in all four limbs and many develop dysarthria and dysphagia as a result of bulbar involvement. [symptoma.com]

Amyotrophic Lateral Sclerosis Type 6

Muscle weakness subsequently spreads to the other limbs and bulbar muscles may become involved. [symptoma.com]

The beginning of symptoms was weakness in upper limbs, without involvement of lower limbs or bulbar functions. [intechopen.com]

Bulbar palsy preceding limb muscle weakness has repeatedly been described and may be observed in up to one third of ALS6 patients, but bulbar involvement doesn't seem to be [symptoma.com]

Spinal Paralytic Poliomyelitis

Paralytic poliomyelitis with bulbar involvement The purely bulbar form of poliomyelitis without limb weakness may occur in children, particularly in those whose tonsils and [sites.google.com]

The mortality from acute paralytic poliomyelitis is 5-10%, but it can reach 20-60% in cases of bulbar involvement. Race Acute poliomyelitis has no racial predilection. [emedicine.medscape.com]

As with skeletal muscle paralysis, bulbar involvement may worsen over 2 to 3 days and, in some patients, affects the respiratory and circulatory centers of the brain stem, [merckmanuals.com]

Superior Limbic Keratoconjunctivitis

[…] is involved in the pathogenesis of SLK. [unboundmedicine.com]

Impression cytology of involved superior bulbar conjunctiva was nearly devoid of goblet cells during the acute stage of the disorder. [ncbi.nlm.nih.gov]

Considering that we did not address the diseased part of the conjunctiva but rather the adjacent conjunctival redundancy, we propose that superior bulbar conjunctivochalasis [unboundmedicine.com]

Juvenile Primary Lateral Sclerosis

involvement in two siblings Full_Paper Eymard-Pierre 2002 Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene Full_Paper [alsod.iop.kcl.ac.uk]

Infantile-onset ascending hereditary spastic paraplegia with bulbar involvement due to the novel ALS2 mutation c.2761C>T. [invitae.com]

Here we describe a ninth ALS2 mutation, in two siblings affected by infantile-onset ascending spastic paraplegia with bulbar involvement [4]. [wikigenes.org]

Pseudobulbar Palsy

In most cases the early symptoms are connected with bulbar involvement. [wikilectures.eu]

PBP is a form of motor neuron disease involving bulbar innervated muscles. [neurosigns.org]

[…] presentation ,when you progressed confirming the diagnosis of MND, seems as if some use it still ,the emotional outbursts also linked to bulbar involvement, I take the. [forum.mndassociation.org]

Amyotrophic Lateral Sclerosis Type 2

involvement, leading to degeneration of motor neurons in the brain and spinal cord. [orpha.net]

Bulbar involvement results in spastic dysarthria and dysphagia. Upper motor neuron dysfunction also causes hyperreflexia. [symptoma.com]

[…] childhood- or adolescent-onset of slowly progressive, severe, distal limb muscle weakness and wasting, in association with pyramidal signs, normal sensation, and absence of bulbar [orpha.net]

Amyotrophic Lateral Sclerosis Type 9

The disease progressed slowly with mild bulbar involvement. [jamanetwork.com]

The beginning of symptoms was weakness in upper limbs, without involvement of lower limbs or bulbar functions. [intechopen.com]

Bulbar involvement is associated with dysarthria and dysphagia. [symptoma.com]

Ligneous Conjunctivitis

Approximately 50% of cases are bilateral, and affected individuals have a predilection for upper eyelid involvement followed by lower eyelid and bulbar involvement.[1] The [journals.lww.com]

Abstract Ligneous conjunctivitis occurred unilaterally in a 74-year-old man after pterygium excision and only involved the bulbar conjunctiva. [ncbi.nlm.nih.gov]

Approximately 50% of cases are bilateral, and affected individuals have a predilection for upper eyelid involvement followed by lower eyelid and bulbar involvement. [1] The [ijo.in]

Bulbar Palsy

In most cases the early symptoms are connected with bulbar involvement. [wikilectures.eu]

involvement, which may become marked and facial fasciculations with moderately raised CK levels Aetiology bulbar palsy ALS progressive bulbar palsy if involves corticobulbar [ozemedicine.com]

Progressive bulbar palsy involves the brain stem. The brain stem is the part of the brain needed for swallowing, speaking, chewing, and other functions. [ebi.ac.uk]

Bulbospinal Poliomyelitis

The clinical profile of cases showed that cases of spinal type without bulbar involvement were more common (83.8%) in comparison to bulbo-spinal cases (16.2%). [indianpediatrics.net]

[…] the 109 cases of bulbar poliomyelitis examined pathologically. [jamanetwork.com]

Spinal polio, the most common form, characterized by asymmetric paresis usually involving the legs. Bulbar polio is a rare condition affecting the cranial nerves [3]. [openneurologyjournal.com]

KMT2B-Related Dystonia

Literature review identified frequent reports of prominent bulbar involvement but failure to thrive is rarely mentioned. [bmcneurol.biomedcentral.com]

Generalized dystonia involving bulbar and cervical muscles, in addition to dystonic cramps, myoclonus, and hemiballismus, were also observed during the course of the follow-up [karger.com]

The disorder is generally characterized by initial lower limb involvement during childhood followed by a more general involvement, usually including the bulbar and cranio-cervical [clinicalepigeneticsjournal.biomedcentral.com]

Amyotrophic Lateral Sclerosis Type 5

involvement, leading to degeneration of motor neurons in the brain and spinal cord. [orpha.net]

The beginning of symptoms was weakness in upper limbs, without involvement of lower limbs or bulbar functions. [intechopen.com]

Here we describe a ninth ALS2 mutation, in two siblings affected by infantile-onset ascending spastic paraplegia with bulbar involvement [4]. [wikigenes.org]

Motor Neuron Disease Type Madras

Distal muscles can also be involved and the tendon reflexes are usually lost, but bulbar involvement is uncommon. [enetmd.com]

involvement, the features of early and severe involvement of facial muscles and sensorineural hearing impairment distinguish our patient from bulbar presentation of ALS. [neurologyindia.com]

Bulbar involvement and atrophy of tongue are frequent features ranging from 45% to 92% respectively. [3], [4] Hearing impairment may either occur at onset or later in the [neurologyindia.com]

Amyotrophic Lateral Sclerosis Type 21

People with ALS who have little or no bulbar muscle weakness may tolerate NIV better than those with significant bulbar involvement (Cazzoli 1996; Aboussouan 1997). [cochranelibrary.com]

Amyotrophic Lateral Sclerosis Type 12

People with ALS who have little or no bulbar muscle weakness may tolerate NIV better than those with significant bulbar involvement (Cazzoli 1996; Aboussouan 1997). [cochranelibrary.com]

CANOMAD Syndrome

involvement and degree of disability,â€ the authors reported, â€œand were not significantly associated with the level of IgM peak value.â€ Most patients (91%) required [ashclinicalnews.org]

In some cases, there is cranial nerve involvement with ocular, sensory or bulbar manifestations [2]. [clinmedjournals.org]

â€œClinical characteristics of CANOMAD were largely similar between patients with or without an overt associated hematologic malignancy, notably in terms of ocular or bulbar [ashclinicalnews.org]

Amyotrophic Lateral Sclerosis Type 17

Bulbar dysfunction 28 From Bramwell: Atlas of Clinical Medicine ALS with Bulbar involvement Usual pattern: Upper > Lower motor neuron involvement Associations Females Older [neuromuscular.wustl.edu]

involvements show more predominant cardiovagal dysfunction than patients with non-bulbar involvement. 20 Other Observations A limited number of reports have shown decreased [touchneurology.com]

Hillemacher T, Gräßel E, Tigges S et al (2004) Depression and bulbar involvement in amyotrophic lateral sclerosis. [link.springer.com]

Malignant Melanoma of the Conjunctiva

Brain, 117: 747-57 [ EČ ][ GS ] Lerman-Sagie, T., Filiano, J., Smith, D.W., Korson, M. (1996) Infantile onset of hereditary ascending spastic paralysis with bulbar involvement [scindeks.ceon.rs]

The mass was located at the superior bulbar conjunctiva involving the superior cornea. The mass was 16 × 9 mm in sizeand elevated. [dbpia.co.kr]

Every part of the conjunctiva may be affected, but MMC most commonly develop in the sun-exposed cornea or bulbar conjunctiva, often involving the limbus. [symptoma.com]

Multicore Myopathy with External Ophthalmoplegia

The cause of the aspiration is thought to have been unsuspected laryngeal incompetence associated with ectodermal dysplasia, the myopathy involving his bulbar muscles and [ncbi.nlm.nih.gov]

Mills Syndrome

involvement[13]. [wjgnet.com]

involvement.11 The two proposed criteria7,8 for PLS require the absence of LMN signs on clinical, and electrophysiological examination during the first three years of disease [ncbi.nlm.nih.gov]

We describe a case of an 82-year-old patient with spastic hemiparesis on the left side for 4 years, slowly progressive, associated with bulbar symptoms, with clinical and [atenaeditora.com.br]