Bulbar Symptoms: Causes & Reasons

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Possible Causes for Bulbar Symptoms

Amyotrophic Lateral Sclerosis Type 10

Difficulty in speaking or swallowing is the initial symptom in the bulbar form of the disease. [aafp.org]

Other symptoms of this disorder include progressive weakness of the lips and impairment and/or loss of function of the tongue, mouth, and/or voice box (bulbar symptoms). [rarediseases.org]

symptoms or signs of cognitive impairment. [jamanetwork.com]

Progressive Bulbar Paralysis

Bulbar symptoms such as dysphagia and dysarthria are frequent features of ALS and can result in reductions in life expectancy and quality of life. [nature.com]

The bulbar palsy affects the lower motor neuron but the signs and symptoms are the same with the bulbar palsy. [symptomscausestreatment.com]

Key points Bulbar symptoms such as dysarthria and dysphagia are frequent features of amyotrophic lateral sclerosis (ALS) and can reduce life expectancy and quality of life [nature.com]

Pseudobulbar Palsy

Bulbar symptoms such as dysphagia and dysarthria are frequent features of ALS and can result in reductions in life expectancy and quality of life. [nature.com]

These bulbar symptoms often may be misinterpreted and lead to a false localization of the ischemic lesion. [ncbi.nlm.nih.gov]

Diagnosis and treatment of bulbar symptoms in amyotrophic lateral sclerosis. Nat Clin Pract Neurol. 2008; 4(7): 366-374. Mitsumoto J. [meducator3.net]

Distal Spinal Muscular Atrophy Type 4

[…] with and without bulbar symptoms 3–30 Progressive SMA Meadows et al. 1969 b 8 6:2 18–62 Arm > leg Slowly progressive disease course, no bulbar symptoms 7–18 Chronic progressive [academic.oup.com]

proximal Yes Yes Lower limb, distal Yes Yes Muscle atrophy Proximal < distal Proximal = distal (generalized) Sensory loss Yes No Areflexia Yes Yes Pyramidal sign No No Bulbar [ojrd.biomedcentral.com]

[…] and signs such as spasticity, weakness and hyperreflexia where the progressive bulbar involvement causes bulbar symptoms such as dysarthria and dysphagia.[6],[4]. [explainmedicine.com]

Myasthenic Crisis

Univariate analysis revealed that events significantly associated with increased risk of POMC include symptom duration before operation >2.75months, preoperative bulbar symptoms [ncbi.nlm.nih.gov]

RESULTS: Univariate analysis revealed preoperative bulbar symptoms (odds ratio = 14.246, P =.001), history of preoperative myasthenic crisis (7.091,.018), and preoperative [ncbi.nlm.nih.gov]

Univariate analysis showed that age at onset, preoperative MGFA class, preoperative MC, presence of bulbar symptoms, operation duration, amount of intraoperative blood loss [ncbi.nlm.nih.gov]

Alexander Disease

Juvenile Alexander disease presents primarily with bulbar symptoms between 2 and 12 years of age. [ncbi.nlm.nih.gov]

On the other hand, symptoms characteristic for adult forms such as hyperreflexia, bulbar symptoms, ataxia and others can also be observed. [symptoma.com]

In contrast to the classical infantile type, patients with juvenile and adult types mainly complain of bulbar symptoms and usually show progressive atrophy of the lower brainstem [ncbi.nlm.nih.gov]

Upper Motor Neuron Disease

These patients were divided into three group based on clinical evidence of upper and lower motor neuron involvement, bulbar symptom; amyotrophic lateral sclerosis(ALS), progressive [e-acn.org]

[…] and signs such as spasticity, weakness and hyperreflexia where the progressive bulbar involvement causes bulbar symptoms such as dysarthria and dysphagia.[6],[4]. [explainmedicine.com]

Sensory signs and symptoms and absence of bulbar symptoms help to diagnose this. Neurophysiological assessment and imaging will confirm the diagnosis. [patient.info]

Lower Motor Neuron Syndrome with Late-Adult Onset

[…] and signs such as spasticity, weakness and hyperreflexia where the progressive bulbar involvement causes bulbar symptoms such as dysarthria and dysphagia.[6],[4]. [explainmedicine.com]

However, lack of upper-extremity weakness and/or atrophy, absence of bulbar symptoms, presence of sensory deficits, and, most importantly, the fluctuating nature of the weakness [clinicaladvisor.com]

Sensory signs and symptoms and absence of bulbar symptoms help to diagnose this. Neurophysiological assessment and imaging will confirm the diagnosis. [patient.info]

Bulbar Poliomyelitis

What are the Symptoms of Bulbar Polio? [epainassist.com]

Bulbar poliomyelitis is a specific type of an extremely rare viral paralytic disease in which the typical findings of acute flaccid paralysis are accompanied by bulbar symptoms [symptoma.com]

This may cause autonomic features - eg, hyper/hypotension, respiratory failure, and bulbar symptoms, such as dysphagia and dysphonia. [patient.info]

Primary Lateral Sclerosis

Unilateral limb slowness or clumsiness was the initial complaint in four, and bulbar symptoms in one. [ncbi.nlm.nih.gov]

METHODS: Six sites enrolled 41 patients who had pure upper motor neuron dysfunction, bulbar symptoms, a normal EMG done within 12 months of enrollment, and onset of symptoms [ncbi.nlm.nih.gov]

Characterized by leg weakness, spasticity, and bulbar symptoms like dysphagia and dysarthria Additional features include cognitive impairment, eye movement abnormalities, [unboundmedicine.com]

Amyotrophic Lateral Sclerosis

symptoms. [ncbi.nlm.nih.gov]

Bulbar symptom and gait disturbance gradually developed, and he was clinically diagnosed with FA syndrome. [ncbi.nlm.nih.gov]

During exsufflation, constriction of the hypopharynx was observed in all subjects regardless of the presence of bulbar symptoms, after the adverse events that occurred during [ncbi.nlm.nih.gov]

Autosomal Dominant Spastic Paraplegia Type 8

Distinctive phenotype observed in our family includes later symptom onset and bulbar involvement despite relatively mild leg spasticity. [neurology.org]

symptoms and fasciculations mimicking amyotrophic lateral sclerosis, Journal of the Neurological Sciences, 364, (45), (2016). [doi.org]

Improvement of bulbar symptoms occurs at median 30 days from onset. [neuroweb.us]

Fazio-Londe Disease

While there is no cure for progressive bulbar palsy or for ALS, doctors can treat symptoms. [ https://rarediseases.info.nih.gov/diseases/10928/progressive-bulbar-palsy ] Synonyms [ebi.ac.uk]

While there is no cure for progressive bulbar palsy or for ALS, doctors can treat symptoms. [monarchinitiative.org]

The most frequent symptoms at onset of progressive bulbar paralysis of childhood has been a unilateral facial paralysis. [en.wikipedia.org]

Spinal and Bulbar Muscular Atrophy

We describe a patient with X-linked spinal and bulbar muscular atrophy (X-SBMA) and myasthenic symptoms. [ncbi.nlm.nih.gov]

This study describes symptoms from the patient's perspective and the impact these symptoms have on QoL. [ncbi.nlm.nih.gov]

While all reported bulbar symptoms, none had disabling deficits. [n.neurology.org]

Amyotrophic Lateral Sclerosis Type 11

Limb symptoms can develop almost simultaneously with bulbar symptoms, and in the vast majority of cases will occur within 1-2 years. [orpha.net]

Patient 1 had only lower motor neuron bulbar symptoms, patient 2 showed mainly pseudobulbar symptoms, and patients 3 and 4 clearly had upper motor and lower motor neuron symptoms [jamanetwork.com]

TARDBP-associated ALS also occur as long-standing symptoms in the upper limbs and with bulbar-onset in Asian patients. [scielo.br]

Autosomal Dominant Spastic Paraplegia Type 10

Distinctive phenotype observed in our family includes later symptom onset and bulbar involvement despite relatively mild leg spasticity. [neurology.org]

PMID: 27084214 [PubMed – in process] Late-onset spastic paraplegia type 10 (SPG10) family presenting with bulbar symptoms and fasciculations mimicking amyotrophic lateral [hspersunite.org.au]

symptoms and fasciculations mimicking amyotrophic lateral sclerosis, Journal of the Neurological Sciences, 364, (45), (2016). [doi.org]

Myasthenia Gravis

The following factors were analysed in relation to POMC: gender, age, duration of symptoms, bulbar symptoms, smoking history, history of myasthenic crisis, comorbidities, [ncbi.nlm.nih.gov]

Although the presentation is typically observed with complaints of vision and bulbar symptoms such as diplopia, dystonia, and dysphagia, this article presents a case study [ncbi.nlm.nih.gov]

Amyotrophic Lateral Sclerosis Type 6

Factors associated with more favorable survival rates include a younger age, male gender, and limb rather than bulbar symptom onset. 5,6 For more information on the disease [mda.org]

TARDBP-associated ALS also occur as long-standing symptoms in the upper limbs and with bulbar-onset in Asian patients. [scielo.br]

Other symptoms of this disorder include progressive weakness of the lips and impairment and/or loss of function of the tongue, mouth, and/or voice box (bulbar symptoms). [rarediseases.org]

Amyotrophic Lateral Sclerosis Type 1

Sensory signs and symptoms and absence of bulbar symptoms help to diagnose this. Neurophysiological assessment and imaging will confirm the diagnosis. [patient.info]

Difficulty in speaking or swallowing is the initial symptom in the bulbar form of the disease. [aafp.org]

Symptoms usually progress first in already affected region Continuous progression once region (bulbar,arms, or legs) involved Other regions involved later Spread usually [neuromuscular.wustl.edu]

Amyotrophic Lateral Sclerosis Type 9

Limb symptoms can develop almost simultaneously with bulbar symptoms, and in the vast majority of cases will occur within 1-2 years. [orpha.net]

symptoms (20%), respiratory muscle weakness (1-3%), generalized weakness in limbs and bulbar muscles (1-9%), axial onset with muscle weakness, muscle atrophy and fasciculations [nnjournal.net]

TARDBP-associated ALS also occur as long-standing symptoms in the upper limbs and with bulbar-onset in Asian patients. [scielo.br]

Distal Spinal Muscular Atrophy Type 5

Sensory signs and symptoms and absence of bulbar symptoms help to diagnose this. Neurophysiological assessment and imaging will confirm the diagnosis. [patient.info]

Type 1 manifests arms more involved than legs and bulbar symptoms developing late. [clinicalgate.com]

Corneal lattice dystrophy, multiple cranial neuropathies (facial and bulbar weakness), cutis laxa. Late generalized polyneuropathy. Symptoms generally worsen with age. [neupsykey.com]

Diphtheritic Neuropathy

In 28%, limb symptoms started or continued to worsen while bulbar symptoms had started recovering. [jnnp.bmj.com]

Thus the clinical course of complications of diphtheritic infection follows a stereotypical pattern with onset of bulbar symptoms 3–6 weeks after initial infection, onset [jnnp.bmj.com]

Limb paralysis from a segmental demyelinating process occurs with temporal regularity, with onset and resolution 35–140 days after the onset of bulbar signs and symptoms [wwwnc.cdc.gov]

Bulbar Palsy

As the muscles of articulation are affected by bulbar palsy, symptoms will present accordingly, such as: Lip trembling Drooling – inability to swallow, saliva gathers in mouth [newyorkfacialparalysis.com]

After stopping aripiprazole, his bulbar symptoms improved. [pedneur.com]

While there is no cure for progressive bulbar palsy or for ALS, doctors can treat symptoms. Last updated: 7/29/2015 How is progressive bulbar palsy diagnosed? [rarediseases.info.nih.gov]

Juvenile Myasthenia Gravis

However, presentation with isolated bulbar symptoms is extremely unusual. [dergipark.org.tr]

In the patient with thymoma, JMG had manifested with ocular myasthenia when she was 10; 2 years later, she displayed generalised involvement and bulbar symptoms. [elsevier.es]

If bulbar muscles are involved there will be nasal regurgitation. Symptoms depend upon weakness. [lupinepublishers.com]

Congenital Myasthenic Syndrome

Symptoms began at the neonatal period with hypotonia, arthrogryposis, bulbar symptoms, and respiratory distress. [ncbi.nlm.nih.gov]

The patient had severe bulbar symptoms, marked axial weakness causing a "dropped head," and some facial and proximal weakness. [zora.uzh.ch]

The patients responded favorably to anticholinesterase treatment, with a clear improvement of clinical symptoms, especially the bulbar symptoms of apneas and swallowing disturbances [ncbi.nlm.nih.gov]

Rapidly worsening bulbar symptoms in a patient with spinobulbar muscular atrophy. [pagepress.org]

Bulbar symptoms include dysarthria, dysphagia, sialorrhea (drooling), and pseudobulbar affect—laughing or crying in exaggeration of or incongruent with mood. [clinicalgate.com]

The loss of lower motor neurons supplying the bulbar musculature results in bulbar symptoms such as difficulty with articulation. [8] Up to 47% of patients also experience [saudija.org]

Transient Neonatal Myasthenia Gravis

[…] if bulbar symptoms are present Compressive cranial neuropathies – MRI can help distinguish Lambert-Eaton myasthenic syndrome - LEMS improves with recurrent use. [pedclerk.bsd.uchicago.edu]

limb, and respiratory muscles - proceeded by ocular MG Initial presentation of MG Ptosis and/or diplopia (50%) Bulbar symptoms- dysarthria, dysphagia, and fatiguable chewing [quizlet.com]

Generalized symptoms manifest at or shortly after birth and may cause generalized symptoms but most patients will have bulbar (feeding difficulty) and/or ocular (ptosis) findings [educatehealth.ca]

Miyoshi Myopathy Type 1

Bulbar or symptoms have not been reported. Etiology MM is caused by mutations in the DYSF gene (2p13), which encodes dysferlin. [orpha.net]

Hereditary Proximal Myopathy with Early Respiratory Failure

The clinical interview During the clinical interview, bulbar symptoms should be assessed. [dovepress.com]

Other symptoms of bulbar weakness will include drooling and changes in voice volume, pitch, or clarity. [dovepress.com]

Patients with bulbar involvement or where bulbar symptoms are anticipated should be considered for early placement of a feeding tube if this is in keeping with the patient [dovepress.com]

Bilateral Leg Weakness

Myasthenia (bulbar symptoms, ptosis, worse with exercise, normal DTR's, respiratory insufficiency, autonomic system), botulism (baby, absent eye movements, bulbar symptoms [pedclerk.bsd.uchicago.edu]

Sensory signs and symptoms and absence of bulbar symptoms help to diagnose this. Neurophysiological assessment and imaging will confirm the diagnosis. [patient.info]

There are no bulbar symptoms and signs. The absence of UMN signs above the LMN signs increases the possibility of this diagnosis. [patient.info]