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15 Possible Causes for Bullous Rash, Degeneration of Epidermal Basal Cells

  • Vasculitis

    There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] Keratinisation Keratinisation is the process by which epidermal cells ( keratinocytes ) undergo maturation and differentiation, as the cell migrates from the basal layer to[dermnetnz.org] Epidermolytic dyskeratosis Epidermolytic dyskeratosis is abnormal epidermal maturation characterised by vacuolar degeneration of the stratum granulosum and stratum spinulosum[dermnetnz.org]

  • Erythema Multiforme

    Acquired rashes in the older child. In: Kleigman RM, Lye PS, Bordini BJ, Toth H, Basel D, eds. Nelson Pediatric Symptom-Based Diagnosis.[nlm.nih.gov] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com] Erythema multiforme major is a form of rash with skin loss or epidermal detachment.[en.wikipedia.org]

  • Epidermolysis Bullosa

    […] layer caused by degeneration of individual epidermal cells Dystrophic EB: pretibial lesion Electron microscopy description Electron microscopy images Images hosted on other[pathologyoutlines.com] […] servers: EB simplex: epidermal basal keratinocytes Back to top[pathologyoutlines.com] Microscopic (histologic) images Images hosted on other servers: EB simplex: intact stratum corneum and upper epidermis, with vesicle formation in the lower epidermis at the basal[pathologyoutlines.com]

  • Lupus Erythematosus

    Bullous rash and brown urine in a systemic lupus erythematous patient treated with hydroxychloroquine. Arthritis Rheum 1995 ; 38 : 440 –443 15 Gibson GE, McEvoy MT.[academic.oup.com] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] Clinical Criteria Acute Cutaneous Lupus OR Subacute Cutaneous Lupus Acute cutaneous lupus : lupus malar rash (do not count if malar discoid), bullous lupus, toxic epidermal[rheumtutor.com]

  • Systemic Lupus Erythematosus

    An uncommon but serious form of lupus rash results in the development of large blisters and is called a "bullous" lupus rash. Joints.[webmd.com] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] […] lupus: a blistering rash, if severe may resemble toxic epidermal necrolysis Maculopapular rash resembling morbilliform drug eruption Mucosal erosions and ulcerations ( lips[dermnetnz.org]

  • Rare Cutaneous Lichen Planus

    Blistering (bullous) lichen planus is rare and usually affects the lower legs.[britishskinfoundation.org.uk] There is a T-cell infiltrate at the dermo-epidermal junction, with vacuolar or liquefactive degeneration of the basal cells of the epidermis.[news-medical.net] A rare form of the disease, familial bullous lichen planus, is inherited.[curejoy.com]

  • Discoid Lupus Erythematosus

    An uncommon but serious form of lupus rash results in the development of large blisters and is called a "bullous" lupus rash. Joints.[webmd.com] A skin biopsy from her cheek revealed hyperkeratosis, focal epidermal atrophy, basal cell degeneration and dilated follicular orifices filled with compact keratin.[ncbi.nlm.nih.gov] […] membrane (best demonstrated by periodic acid-Schiff staining) and vacuolar degeneration of the basal cells along with perivascular and peri-appendageal inflammatory cell[doi.org]

  • Actinic Lichen Planus

    Bullous: Fluid-filled blisters and lesions that can occur in the mouth, genitals, lower limbs and trunk.[draxe.com] Histology classically demonstrates hyperkeratosis, epidermal thinning, vacuolar degeneration of the basal cell layer, lymphohistiocytic band-like infiltrate, variable Civatte[jcadonline.com] […] of the basal cell layer with pigment incontinence and keratinocyte apoptosis.[e-ijd.org]

  • Chilblain Lupus Erythematosus

    […] on arms, sometimes forming large plaques and spreading widely Photosensitivity (a rash on all recently sun- exposed skin ) Cheilitis and mouth ulcers Blisters ( bullous LE[dermnetnz.org] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com] […] acute cutaneous LE may include: Malar eruption or ‘butterfly rash ’ ( erythema and oedema of cheeks, sparing nasolabial folds) lasting hours to days Erythematous papular rash[dermnetnz.org]

  • Bullous Lichen Planus

    Dermatological adverse events such as pruritus and rash have been reported in various clinical trials.[ncbi.nlm.nih.gov] Degeneration of basal epidermal cells leads to exposure of the basement membrane antigens.[jemds.com] The extensive vacuolation of basal cells led to the appearance of a dermo-epidermal cleft [Figure 3] .[ijdvl.com]

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