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15 Possible Causes for Bullous Rash, Degeneration of Epidermal Basal Cells, Eosinophilia

  • Erythema Multiforme

    Acquired rashes in the older child. In: Kleigman RM, Lye PS, Bordini BJ, Toth H, Basel D, eds. Nelson Pediatric Symptom-Based Diagnosis.[nlm.nih.gov] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com] […] cytopenia, vasculitis, acute allergic interstitial nephritis, occupational contact dermatitis, photoallergic dermatitis, maculopapular eruption, erythroderma, Drug rash with eosinophilia[aaaai.org]

  • Vasculitis

    All serologic studies were normal except for increased levels of rheumatoid factor and eosinophilia.[ncbi.nlm.nih.gov] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] Anaemia, Leukocytosis, Eosinophilia. Antineutrophil cytoplasmic antibodies (ANCA). Elevated factor VIII - related antigen (von Willebrand factor).[pmmonline.org]

  • Graft-versus-Host-Disease

    […] nausea, vomiting, or anorexia, with a positive upper GI biopsy result 2 Maculopapular rash 25%-50% BSA 3.1-6 mg/dL 1000-1500 mL/d (Child: 20-30 mL/kg/d) 3 Maculopapular rash[clinicaladvisor.com] Skin biopsies were consistent with GVHD, showing vacuolar degeneration of the basal layer of the epithelium, epidermal infiltration by lymphocytes and necrotic eosinophilic[ncbi.nlm.nih.gov] But other patients with chronic GVHD never have eosinophilia, so the lack of eosinophilia does not influence the diagnosis of chronic GVHD.[cancertherapyadvisor.com]

  • Systemic Lupus Erythematosus

    An uncommon but serious form of lupus rash results in the development of large blisters and is called a "bullous" lupus rash. Joints.[webmd.com] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] In rare cases, pleural eosinophilia is associated with connective tissue disease.[ncbi.nlm.nih.gov]

  • Pityriasis Circinata

    The lesions may be punctate, erosive, bullous or hemorrhagic. They disappear concomitantly as the skin eruption fades.[ncbi.nlm.nih.gov] In the drug induced form there is no herald patch, individual lesions tend to be violet-red in colour, pruritus is more severe, and eosinophilia may be present.[doi.org] Besides, histology shows epidermal atrophy and basal layer degeneration.[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    Bullous rash and brown urine in a systemic lupus erythematous patient treated with hydroxychloroquine. Arthritis Rheum 1995 ; 38 : 440 –443 15 Gibson GE, McEvoy MT.[academic.oup.com] Other diagnoses included in these codes but without sufficient sample sizes to analyze individually are Felty’s syndrome, eosinophilia myalgia syndrome, juvenile chronic polyarthritis[doi.org] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br]

  • Erythema Annulare Centrifugum

    ) - Diaper rash - Urushiol-induced contact dermatitis - Contact dermatitis - Erythroderma - Lichen simplex chronicus - Prurigo nodularis - Itch - Pruritus ani - Nummular dermatitis[bionity.com] A 65-year-old male presented with a history of disseminated erythema annulare centrifugum lesions and a high peripheral blood eosinophilia (55%).[ncbi.nlm.nih.gov] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[ijpd.in]

  • Bullous Lichen Planus

    Dermatological adverse events such as pruritus and rash have been reported in various clinical trials.[ncbi.nlm.nih.gov] Histopathology showed a subepidermal blistering disease with tissue eosinophilia consistent with lichen planus pemphigoides (LPP)(Figure 2); direct immunofluorescence was[mdedge.com] Degeneration of basal epidermal cells leads to exposure of the basement membrane antigens.[jemds.com]

  • Actinic Lichen Planus

    Bullous: Fluid-filled blisters and lesions that can occur in the mouth, genitals, lower limbs and trunk.[draxe.com] Carcinoma Bowen's Disease Chronic Actinic Skin Damage Cornu Cutaneum Discoid Lupus Erythematosus (DLE) Disseminated Superficial Actinic Porokeratosis Facial Granuloma with Eosinophilia[skincancer.dermis.net] Histology classically demonstrates hyperkeratosis, epidermal thinning, vacuolar degeneration of the basal cell layer, lymphohistiocytic band-like infiltrate, variable Civatte[jcadonline.com]

  • Chilblain Lupus Erythematosus

    […] on arms, sometimes forming large plaques and spreading widely Photosensitivity (a rash on all recently sun- exposed skin ) Cheilitis and mouth ulcers Blisters ( bullous LE[dermnetnz.org] Blood tests: FBC may show raised white count/eosinophilia or lymphopenia. Anaemia may be seen. ESR is often raised ( 65% of cases).[patient.info] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com]

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