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14 Possible Causes for Bullous Rash, Degeneration of Epidermal Basal Cells, Joint Swelling

  • Vasculitis

    There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] swelling, warmth, painful range of motion Polyarteritis, Wegener's granulomatosis, Churg-Strauss vasculitis Skin lesions Livedo reticularis, necrotic lesions, ulcers, nodules[aafp.org] Muscle pains, joint pains, inflamed joints, swelling and trouble moving normally.[draxe.com]

  • Lupus Erythematosus

    Bullous rash and brown urine in a systemic lupus erythematous patient treated with hydroxychloroquine. Arthritis Rheum 1995 ; 38 : 440 –443 15 Gibson GE, McEvoy MT.[academic.oup.com] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br] […] hip pain (osteonecrosis) Physical exam butterfly malar rash large joint swelling and synovitis hand and wrist manifestation are common (90%) swelling and synovitis of PIPs[orthobullets.com]

  • Systemic Lupus Erythematosus

    An uncommon but serious form of lupus rash results in the development of large blisters and is called a "bullous" lupus rash. Joints.[webmd.com] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com] While denying a history of any rash, photosensitivity, oral ulcers, or seizures, his physical examination did reveal metacarpal phalangeal joint swelling along with noted[ncbi.nlm.nih.gov]

  • Erythema Multiforme

    Acquired rashes in the older child. In: Kleigman RM, Lye PS, Bordini BJ, Toth H, Basel D, eds. Nelson Pediatric Symptom-Based Diagnosis.[nlm.nih.gov] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com] Sometimes there is arthralgia or even joint swelling.[ncbi.nlm.nih.gov]

  • Discoid Lupus Erythematosus

    An uncommon but serious form of lupus rash results in the development of large blisters and is called a "bullous" lupus rash. Joints.[webmd.com] […] hydropic degeneration of the basal cell layer, thickening of the basement membrane zone, telangiectasia, superficial and deep perivascular and periadnexal lymphocytic inflammatory[scielo.br] They may sometime have symptoms of joint pain and joint swelling.[steadyhealth.com]

  • Graft-versus-Host-Disease

    […] nausea, vomiting, or anorexia, with a positive upper GI biopsy result 2 Maculopapular rash 25%-50% BSA 3.1-6 mg/dL 1000-1500 mL/d (Child: 20-30 mL/kg/d) 3 Maculopapular rash[clinicaladvisor.com] Skin biopsies were consistent with GVHD, showing vacuolar degeneration of the basal layer of the epithelium, epidermal infiltration by lymphocytes and necrotic eosinophilic[ncbi.nlm.nih.gov] A patient with GVHD may have Abdominal swelling Jaundice (yellow discoloration of the skin and/or eyes) Abnormal liver function test results Muscles and Joints.[lls.org]

  • Pityriasis Circinata

    The lesions may be punctate, erosive, bullous or hemorrhagic. They disappear concomitantly as the skin eruption fades.[ncbi.nlm.nih.gov] […] pain, lymph node swelling and headache) that precede the appearance of the herald patch.[patient.info] , lymph node swelling, sore throat, and low-grade fever.[mdedge.com]

  • Rare Cutaneous Lichen Planus

    Blistering (bullous) lichen planus is rare and usually affects the lower legs.[britishskinfoundation.org.uk] There is a T-cell infiltrate at the dermo-epidermal junction, with vacuolar or liquefactive degeneration of the basal cells of the epidermis.[news-medical.net] (inflammation) and painful joints antimalarial tablets – these help to treat and prevent malaria (a tropical disease spread by infected mosquitoes) Diagnosis Lichen planus[your.md]

  • Chilblain Lupus Erythematosus

    […] on arms, sometimes forming large plaques and spreading widely Photosensitivity (a rash on all recently sun- exposed skin ) Cheilitis and mouth ulcers Blisters ( bullous LE[dermnetnz.org] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com] […] with swelling, tenderness, or an effusion; rarely deforming (normal x-ray ) Serositis Pleuritis according to a history of pleuritic pain or a pleuritic rub during auscultation[amboss.com]

  • Cutaneous Lupus Erythematosus

    Abstract A 29-year-old woman with a 1.5 year history of photosensitive skin lesions on her hands presented with a malar rash, bullous lesions on her hands, and was diagnosed[ncbi.nlm.nih.gov] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br] These criteria include the butterfly rash and joint swelling.[northshore.org]