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15 Possible Causes for Bullous Rash, Degeneration of Epidermal Basal Cells, Syphilis

  • Erythema Multiforme

    Acquired rashes in the older child. In: Kleigman RM, Lye PS, Bordini BJ, Toth H, Basel D, eds. Nelson Pediatric Symptom-Based Diagnosis.[nlm.nih.gov] Secondary syphilis, the hematogenous spread of Treponema pallidum, usually occurs 4-10 weeks after initial exposure.[ncbi.nlm.nih.gov] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com]

  • Vasculitis

    […] vasculitic workup assists in determining the organ systems involved and may include urinalysis, C-reactive protein, urea nitrogen/creatinine, CBC, ANCA and ANA testing, syphilis[arupconsult.com] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] […] septicemic states, including meningococcal, gonococcal, Pseudomonas and Streptococcal septicemia, infective endocarditis (particularly due to Staphylococcus aureus), secondary syphilis[pathologyoutlines.com]

  • Epidermolysis Bullosa

    Congenital syphilis. Ectodermal dysplasia. Epidermolytic hyperkeratosis. Intrauterine infection with herpes simplex virus.[patient.info] […] layer caused by degeneration of individual epidermal cells Dystrophic EB: pretibial lesion Electron microscopy description Electron microscopy images Images hosted on other[pathologyoutlines.com] […] friction blisters, staphylococcal pyoderma, staphylococcal scalded skin syndrome, toxic epidermal necrolysis, epidermolysis bullosa, exfoliative erythroderma, congenital syphilis[nature.com]

  • Lupus Erythematosus

    Bullous rash and brown urine in a systemic lupus erythematous patient treated with hydroxychloroquine. Arthritis Rheum 1995 ; 38 : 440 –443 15 Gibson GE, McEvoy MT.[academic.oup.com] We subsequently reported structures analogous to iSALT in human secondary syphilis, suggesting that iSALT can also exist in humans.[ncbi.nlm.nih.gov] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Erythema Annulare Centrifugum

    ) - Diaper rash - Urushiol-induced contact dermatitis - Contact dermatitis - Erythroderma - Lichen simplex chronicus - Prurigo nodularis - Itch - Pruritus ani - Nummular dermatitis[bionity.com] Diagnosis: atypical secondary syphilis. Treatment: 0.8 million units of procaine penicillin i.m. per day 20 day.[academic.oup.com] Histopathology demonstrates epidermal atrophy, basal cell degeneration, and mononuclear cell infiltrate in the dermis.[ijpd.in]

  • Systemic Lupus Erythematosus

    An uncommon but serious form of lupus rash results in the development of large blisters and is called a "bullous" lupus rash. Joints.[webmd.com] […] with lupus tested positive for syphilis.[hopkinslupus.org] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Discoid Lupus Erythematosus

    An uncommon but serious form of lupus rash results in the development of large blisters and is called a "bullous" lupus rash. Joints.[webmd.com] Perioral dermatitis and rosacea Sarcoidosis Lichen planus Lichen planopilaris Dermatomyositis Syphilis (see secondary syphilis ) Porphyria (see erythropoietic protoporphyria[visualdx.com] A skin biopsy from her cheek revealed hyperkeratosis, focal epidermal atrophy, basal cell degeneration and dilated follicular orifices filled with compact keratin.[ncbi.nlm.nih.gov]

  • Chronic Lichenoid Pityriasis

    […] and eczema Atopic dermatitis · Seborrhoeic dermatitis ( Dandruff, Cradle cap ) · Contact dermatitis ( Diaper rash, Urushiol-induced contact dermatitis ) · Erythroderma ·[wikidoc.org] A few, such as secondary syphilis and viral-associated lesions, also can be excluded based on serologic tests.[dermaamin.com] Epidermal changes include spongiosis and, characteristically, vacuolar degeneration of stratum basale. [22] Lymphocytic exocytosis into the epidermis is seen in EM as also[e-ijd.org]

  • Actinic Lichen Planus

    Bullous: Fluid-filled blisters and lesions that can occur in the mouth, genitals, lower limbs and trunk.[draxe.com] […] reaction frequently are absent (Table 2). 2-4 Differential diagnosis of lichen planus actinicus includes discoid lupus erythematosus, granuloma annulare, melasma, secondary syphilis[mdedge.com] Histology classically demonstrates hyperkeratosis, epidermal thinning, vacuolar degeneration of the basal cell layer, lymphohistiocytic band-like infiltrate, variable Civatte[jcadonline.com]

  • Rare Cutaneous Lichen Planus

    Blistering (bullous) lichen planus is rare and usually affects the lower legs.[britishskinfoundation.org.uk] Differential Diagnosis (Other conditions with similar appearance) Graft versus host disease Psoriasis, Guttate Lichen Nitidus Psoriasis, Plaque Lichen Simplex Chronicus Syphilis[ozarkderm.com] There is a T-cell infiltrate at the dermo-epidermal junction, with vacuolar or liquefactive degeneration of the basal cells of the epidermis.[news-medical.net]

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