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14 Possible Causes for Bullous Rash, Degeneration of Epidermal Basal Cells, Thrombocytopenia

  • Graft-versus-Host-Disease

    […] in patients without thrombocytopenia and 26% in those with thrombocytopenia because of increased infectious mortality in the latter group.[doi.org] […] nausea, vomiting, or anorexia, with a positive upper GI biopsy result 2 Maculopapular rash 25%-50% BSA 3.1-6 mg/dL 1000-1500 mL/d (Child: 20-30 mL/kg/d) 3 Maculopapular rash[clinicaladvisor.com] Skin biopsies were consistent with GVHD, showing vacuolar degeneration of the basal layer of the epithelium, epidermal infiltration by lymphocytes and necrotic eosinophilic[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] Bullous rash and brown urine in a systemic lupus erythematous patient treated with hydroxychloroquine. Arthritis Rheum 1995 ; 38 : 440 –443 15 Gibson GE, McEvoy MT.[academic.oup.com] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br]

  • Vasculitis

    ‘Other side effects include hepatitis, vasculitis, and thrombocytopenia.’[en.oxforddictionaries.com] There is sparse scattered lymphocytic infiltration centred around the basal layer /- vacuolar degeneration of the basal layer.[dermnetnz.org] This hypothesis is supported by the presence of arthritis, thrombocytopenia, lowgrade proteinuria, pericardial effusion.[actarheuma.com]

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] An uncommon but serious form of lupus rash results in the development of large blisters and is called a "bullous" lupus rash. Joints.[webmd.com] […] of the basal layer and epidermal atrophy, lymphadenopathy, pleurisy or pericarditis, glomerular lesions, anemia, hyperglobulinemia, and a positive LE cell test result, with[medical-dictionary.thefreedictionary.com]

  • Erythema Multiforme

    […] with features of oral ulcers, arthritis, immunological (positive anti-nuclear antibody in speckled pattern, anti-ds DNA, anti-Sm), hematological (anemia, lymphopenia and thrombocytopenia[e-ijd.org] Acquired rashes in the older child. In: Kleigman RM, Lye PS, Bordini BJ, Toth H, Basel D, eds. Nelson Pediatric Symptom-Based Diagnosis.[nlm.nih.gov] Pathologic findings include liquefactive degeneration of the basal epidermal cells, necrotic keratinocytes, and exocytosis of lymphocytes.[onlinelibrary.wiley.com]

  • Epidermolysis Bullosa

    Leber's congenital amaurosis 1 ) JAK-STAT Type I cytokine receptor : GH ( Laron syndrome ) CSF2RA ( Surfactant metabolism dysfunction 4 ) MPL ( Congenital amegakaryocytic thrombocytopenia[en.wikipedia.org] […] layer caused by degeneration of individual epidermal cells Dystrophic EB: pretibial lesion Electron microscopy description Electron microscopy images Images hosted on other[pathologyoutlines.com] […] servers: EB simplex: epidermal basal keratinocytes Back to top[pathologyoutlines.com]

  • Cutaneous Lupus Erythematosus

    (6.9%) and 3 SCLE cases (12%) defined as SLE by ARA criteria and 1, 3 and 3, respectively, by EADV criteria had a renal or neurological disorder, hemolytic anemia and/or thrombocytopenia[dx.doi.org] Abstract A 29-year-old woman with a 1.5 year history of photosensitive skin lesions on her hands presented with a malar rash, bullous lesions on her hands, and was diagnosed[ncbi.nlm.nih.gov] […] of basal cells; 4) a predominantly lymphocytic infiltrate along the dermal-epidermal junction, around the fair follicles and eccrine ducts, in an interstitial pattern; 14[scielo.br]

  • Discoid Lupus Erythematosus

    Although thrombocytopenia is common in lupus, serious bleeding as a result of the low number of platelets usually does not occur.[resources.lupus.org] An uncommon but serious form of lupus rash results in the development of large blisters and is called a "bullous" lupus rash. Joints.[webmd.com] […] hydropic degeneration of the basal cell layer, thickening of the basement membrane zone, telangiectasia, superficial and deep perivascular and periadnexal lymphocytic inflammatory[scielo.br]

  • Chilblain Lupus Erythematosus

    […] psychosis ; both in the absence of offending drugs or known metabolic derangements Laboratory tests Hematologic disorders Autoimmune hemolytic anemia with reticulocytes OR Thrombocytopenia[amboss.com] […] on arms, sometimes forming large plaques and spreading widely Photosensitivity (a rash on all recently sun- exposed skin ) Cheilitis and mouth ulcers Blisters ( bullous LE[dermnetnz.org] In particular, skin histopathology of DLE shows classical features: vacuolar degeneration of basal cell layer; thickened basement membrane; orthokeratosis with follicular[ped-rheum.biomedcentral.com]

  • Bullous Lichen Planus

    […] and peripheral radiating white lines *Oral lesions may occur in SLE and CCLE Systemic Lupus Erythematosus - Laboratory Abnormalities Hematologic changes: Anemia Leukopenia Thrombocytopenia[quizlet.com] Dermatological adverse events such as pruritus and rash have been reported in various clinical trials.[ncbi.nlm.nih.gov] Degeneration of basal epidermal cells leads to exposure of the basement membrane antigens.[jemds.com]

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