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212 Possible Causes for Burning Pain, Leg Swelling, Protein C Deficiency

  • Vein Disorder

    Vein Disorders: Achy, tired, heavy feeling in the area of the varicose veins Leg cramps, Restless legs at night Itching, Rashes, bleeding Burning or throbbing pain along with[memphisvein.com] Swelling of the leg is a further sign that damaged or diseased vein valves are not functioning properly.[cvvcenters.com] […] of natural anticoagulant (blood-thinning) proteins (antithrombin, protein C, protein S) Elevated blood counts Abnormal fibrinolysis (the breakdown of fibrin) Abnormal changes[webmd.com]

  • Lymphedema

    Some other symptoms, which can also accompany the swelling of lymphedema, include: warmth, itching or redness a tingling feeling or burning pains chills and fever reduced[leading-medicine-guide.com] Lymphedema is the swelling of a body part (usually arms or legs). This can occur after radiation or removal of lymph nodes.[allinahealth.org] Learn more Sometimes an injury, infection, burn, or other trauma to the arm triggers lymphedema.[mskcc.org]

  • Pulmonary Embolism

    Main symptoms of a pulmonary embolism include chest pain that may be any of the following: Under the breastbone or on one side Sharp or stabbing Burning, aching, or a dull[medlineplus.gov] Eight variables were included in a block rule: Age 50 years, pulse 100 bpm, SaO(2) 94%, no unilateral leg swelling, no hemoptysis, no recent trauma or surgery, no prior PE[ncbi.nlm.nih.gov] A hypercoaguable workup must be carried out to screen for antithrombin 3 deficiency, protein C or protein S deficiency, connective tissue disorders and homocystinurea.[symptoma.com]

  • Liver Cirrhosis

    The rash is often painful and causes a burning sensation.[emedicinehealth.com] You may also get swelling in your legs, ankles or feet, known as peripheral oedema.[britishlivertrust.org.uk] Thrombin activation and microthrombosis of intrahepatic portal venules is a common feature in liver cirrhosis, due in part to relative protein C deficiency and altered coagulation-anticoagulation-fibrinolysis[ncbi.nlm.nih.gov]

  • Stroke

    The pain is a mixture of sensations, including heat and cold, burning, tingling, numbness, and sharp stabbing and underlying aching pain. cerebral blood flow (CBF) -the flow[web.archive.org] These include: preeclampsia (high blood pressure during pregnancy that can cause swelling in the hands, feet, and legs) premature rupture of the membranes (when a woman's[kidshealth.org] C deficiency, protein S deficiency, pregnancy) Sickle cell disease Fibromuscular dysplasia Arterial dissections Vasoconstriction associated with substance abuse (eg, cocaine[emedicine.com]

  • May-Thurner Syndrome

    […] in the thigh or hip, burning pain in the foot, lumbar back pain, issues similar to sciatic nerve pain, disproportionately swollen left thigh, or swelling of the veins and[clotcare.com] But providers should always rule out May-Thurner in a woman with unilateral swelling – typically in the left leg.[kansashealthsystem.com] S or Protein C deficiency or Anti-Thrombin III deficiency.[vascularcarecentre.com]

  • Fabry Disease

    On history taking patient gave history of severe burning pain in both hands and feet since age of 9 yrs.[ncbi.nlm.nih.gov] […] in the legs, muscle pain, back pain, paleness of the skin, slow heart rate, hives, low blood pressure, face swelling, rash and sleepiness.[fabrazyme.com] This method used a combination of monoclonal and polyclonal antibodies raised against each specific deficient enzyme and saposin C.[clinchem.org]

  • Varicose Ulcer

    Agents such as cadexomer iodine or ionized silver are generally well tolerated, although some patients experience burning pain, especially immediately after the application[o-wm.com] – decreased production of protein by the liver causes tissue swelling An initial assessment of leg swelling will include a leg ultrasound at Palm Clinic to confirm or exclude[palmclinic.co.nz] […] disorders (antiphospholipid antibody syndrome, antithrombin III, protein C or S deficiency, essential thrombocythemia, thrombotic thrombocytopenic purpura, polycythemia,[intechopen.com]

  • Meralgia Paresthetica

    It may take time for the burning pain to stop and, in some cases, numbness will persist despite treatment.[orthoinfo.aaos.org] Depending on the cause, your doctor may recommend the following conservative treatments: Physical therapy to strengthen the muscles of your legs and buttocks and reduce injury[hopkinsmedicine.org] […] postulated existence of a deficient myo-inositol-dependent phospholipid-derived protein kinase C agonist (potentially diacylglycerol) in diabetic nerve that regulates nerve[academic.oup.com]

  • Hereditary Angioedema

    The most common side effects of FIRAZYR include: redness, bruising, swelling, warmth, burning, itching, irritation, hives, numbness, pressure, or pain at the injection site[firazyr.com] Symptoms include: Recurrent swelling in the arms, legs, belly genitalia, throat or face. Swelling in the throat can cause severe problems with breathing.[cincinnatichildrens.org] They had low C4 and C1-INH protein concentrations and functions. A mutation (c.1247T A) in C1-INH gene was detected.[ncbi.nlm.nih.gov]

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