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17 Possible Causes for Burr Cell, Coombs Negative Hemolytic Anemia, Thrombotic Thrombocytopenic Purpura

  • Hemolytic Uremic Syndrome

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[wwwn.cdc.gov] BACKGROUND: Hemolytic uremic syndrome is characterized by acute renal failure, thrombocytopenia, and Coombs-negative hemolytic anemia.[ncbi.nlm.nih.gov] Thrombotic thrombocytopenic purpura associated with ticlopidine-Thrombotic Thrombocytopenic Purpura (TTP) 271 a review of 60 cases. Ann Intern Med 1998;128: 541–544.[doi.org]

  • Microangiopathic Hemolytic Anemia

    - schistocytes, “burr cells”, “helmet cells” and “triangle cells”. 6.[slideshare.net] The patients presented with an acute onset of Coombs negative hemolytic anemia and fragmentocytes in the peripheral blood smear which are typical for MAHA.[ncbi.nlm.nih.gov] The similarity of the mother's illness to thrombotic thrombocytopenic purpura and of the daughter's to adult hemolytic uremic syndrome suggests that these diseases are variants[ncbi.nlm.nih.gov]

  • Acquired Spherocytosis

    Crenated / Burr cells / Echinocytes (Echinocytes, or burr cells or crenated red cells, in contrast, have shorter, sharp to blunt spicules of uniform length which are more[slideshare.net] -Immunosuppression Coomb's Negative Hemolytic Anemia (4 Types) -Infection -Paroxysmal Nocturnal Hemoglobinuria (PNH) -Severe Liver Disease -Hypophosphatemia Microorganisms[quizlet.com] Red cell morphology: eg, haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura.[patient.info]

  • Erythrocyte Membrane Abnormality

    The poikilocytes caused by membrane abnormalities are: Acanthocytes (Spur Cells) Codocytes (Target Cells) Echinocytes and Burr Cells Spherocytes Stomatocytes (Mouth Cells)[theartofmed.wordpress.com] Deficiency of protein 4.2 in erythrocytes from a patient with a Coombs negative hemolytic anemia: evidence for a role of protein 4.2 in stabilizing ankyrin on the membrane[nejm.org] Microangiopathic HemolyticAnemiaCauses Vascular abnormalities– Thrombotic thrombocytopenic purpura– Renal lesions Malignant hypertension Glomerulonephritis Preeclampsia[slideshare.net]

  • Cerebral Thrombotic Thrombocytopenic Purpura

    cells, helmet-shaped RBCs, normoblasts, reticulocytosis, unconjugated BR, Hb, hemosiderin, haptoglobin, proteinuria Management Corticosteroids, aspirin, dipyridamole, Igs[medical-dictionary.thefreedictionary.com] hemolytic anemia with red blood cell fragmentation.[rheumaknowledgy.com] KEYWORDS: Cerebral microbleeds; MRI; ischemic stroke; thrombotic thrombocytopenic purpura[ncbi.nlm.nih.gov]

  • Atypical Hemolytic Uremic Syndrome

    A peripheral blood smear (PBS) was performed, which contained schistocytes (32%) with helmet and burr cells.[ncbi.nlm.nih.gov] Hemolytic uremic syndrome is characterized by acute renal failure, thrombocytopenia, and Coombs-negative hemolytic anemia.[ncbi.nlm.nih.gov] Thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS) are thrombotic microangiopathies (TMAs) that can present in pregnancy.[ncbi.nlm.nih.gov]

  • Congenital Heinz Body Hemolytic Anemia

    Burr Cells: Liver disease Renal disease Severe burns Bleeding gastric ulcers Maybe artifact Echinocyte (Burr Cell) Acanthocyte vs Echinocyte Howell-Jelly: are intracellular[medical-labs.net] Cut-off value of red-blood-cell-bound IgG for the diagnosis of Coombs-negative autoimmune hemolytic anemia. Am J Hematol. 2009 Feb. 84(2):98-101. [Medline]. [Full Text].[emedicine.medscape.com] thrombocytopenic purpura ) Presence of a type of immature red blood cells called normoblasts may be due to: Cancer that has spread to bone marrow Blood disorder called erythroblastosis[m.ufhealth.org]

  • Uremic Anemia

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[wwwn.cdc.gov] In view of Coombs-negative hemolytic anemia, thrombocytopenia, and acute renal failure with schistocytes on blood smear, a diagnosis of HUS was made complicating acute pancreatitis[ijccm.org] Thrombotic thrombocytopenic purpura (similar to hemolytic-uremic syndrome ) involves nonimmunologic platelet destruction.[merckmanuals.com]

  • Acquired Thrombotic Thrombocytopenic Purpura

    cells, helmet-shaped RBCs, normoblasts, reticulocytosis, unconjugated BR, Hb, hemosiderin, haptoglobin, proteinuria Management Corticosteroids, aspirin, dipyridamole, Igs[medical-dictionary.thefreedictionary.com] BACKGROUND: Thrombotic thrombocytopenic purpura is a rare thrombotic microangiopathy, related to a severe ADAMTS13 deficiency (a disintegrin and metalloprotease with thromboSpondin[ncbi.nlm.nih.gov] Diagnosis is performed demonstrating microangiopathic hemolytic anemia, a negative direct Coombs test and thrombocytopenia.[elsevier.es]

  • Uremic Pneumonitis

    Diagnosis Peripheral blood smear establishes the presence of MAHA by schistocytes, burr cells, helmet cells etc.[omicsonline.org] Because hemolytic anemia is nonimmune, results of Coombs testing is negative.[emedicine.medscape.com] They fulfilled the criteria for HUS [hemolytic anemia with microangiopathic changes on peripheral blood smear (Burr cells), acute renal failure, and thrombocytopenia] and[clinchem.aaccjnls.org]

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