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55 Possible Causes for Burr Cell, Decreased Platelet Count

  • Hemolytic Uremic Syndrome

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[wwwn.cdc.gov] This results in platelet activation endothelial cell damage, and white blood cell activation, leading to systemic TMA, which manifests as decreased platelet count, hemolysis[en.wikipedia.org] Title Other Names: HUS; Acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells') Categories: Hemolytic[rarediseases.info.nih.gov]

  • Microangiopathic Hemolytic Anemia

    - schistocytes, “burr cells”, “helmet cells” and “triangle cells”. 6.[slideshare.net] Isolated decrease in red blood cells (hemoglobin) Anemia Isolated decrease in platelets Thrombocytopenia Isolated decrease in white blood cell count Leukopenia Decrease in[morningreporttgh.blogspot.com] -schistocytes -fragements -burr cells -microspherocytes What are some causes of microangiopathic hemolytic anemia?[quizlet.com]

  • Folate-Deficiency Anemia

    Significant blood test findings include macrocytosis, decreased reticulocyte count, abnormal platelets, and a serum folate less than 4 mg/ml.[innvista.com]

  • HELLP Syndrome

    Burr cells Schistocytes Reticulocyte count – consider to evaluate for presence of hemolysis Liver enzymes AST – 2 times the upper reference limit meets criteria LDH – markedly[arupconsult.com] Despite considerable patient variation, most gravid women with HELLP syndrome had decreasing platelet counts until 24 to 48 hours after delivery.[ncbi.nlm.nih.gov] Postoperatively, the platelet count and antithrombin III level decreased, and computed tomography revealed intramuscular hematomas that possibly were related to vascular injury[ncbi.nlm.nih.gov]

  • Preeclampsia

    […] hemodilution of pregnancy Peripheral smear (schistocytes, burr cells, echinocytes) Increased bilirubin ( 1.2 mg/dL) Thrombocytopenia ( 100,000) due to hemolysis and low platelet[emedicine.com] Liver function tests and platelet counts must be performed to document decreasing values prior to hospital discharge.[emedicine.com] Hematologic Studies A complete blood cell (CBC) count may reveal the following: Anemia due to microangiopathic hemolysis, hemoconcentration due to third spacing, or physiologic[emedicine.com]

  • Fetal Erythroblastosis

    Schistocytes, as a sign of disseminated intravascular coagulation and burr cells, are present, as well as neutropenia and thrombocytopenia.[symptoma.com] If there is extensive disseminated intravascular coagulation, schistocytes and burr cells may be observed and neutropenia and thrombocytopenia may occur.[patient.info] He or she will be anemic, with increased reticulocyte count, anisocytosis, spherocytosis, and young (nucleated, immature) red blood cells released into circulation.[symptoma.com]

  • Cerebral Thrombotic Thrombocytopenic Purpura

    cells, helmet-shaped RBCs, normoblasts, reticulocytosis, unconjugated BR, Hb, hemosiderin, haptoglobin, proteinuria Management Corticosteroids, aspirin, dipyridamole, Igs[medical-dictionary.thefreedictionary.com] The persistent decrease in platelet count initially posed limitations as the patient needed to undergo an invasive diagnostic procedure.[actamedicaphilippina.com.ph] […] hemolytic anemia Often severe with Hb 7-9g/dl; severity not related to other organ system dysfunction Negative Coombs' test Smear shows signs of microangiopahy: helmet & burr[faculty.washington.edu]

  • Eclampsia

    […] hemodilution of pregnancy Peripheral smear (schistocytes, burr cells, echinocytes) Increased bilirubin ( 1.2 mg/dL) Thrombocytopenia ( 100,000) due to hemolysis and low platelet[emedicine.com] […] in platelet count to less than 100 x 109 per litre Ø Abnormal liver enzymes (ALT or ASTrising to above 70 iu/litre).[bjmp.org] Liver function tests and platelet counts must be performed to document decreasing values prior to hospital discharge.[emedicine.com]

  • Langerhans-Cell Histiocytosis

    Langerhans cell histiocytosis (LCH) developing in a burr hole site for chronic subdural hematoma is extremely rare.[ncbi.nlm.nih.gov] Langerhans cell histiocytosis was diagnosed after biopsy, and the lesion regressed after cladribine treatment.[ncbi.nlm.nih.gov] Yosuke Moteki, Masatoshi Yamada, Atsushi Shimizu, Naoki Suzuki and Tomonori Kobayashi, Langerhans Cell Histiocytosis of the Skull in a Burr Hole Site Covered with Hydroxyapatite[oadoi.org]

  • Atypical Hemolytic Uremic Syndrome

    A peripheral blood smear (PBS) was performed, which contained schistocytes (32%) with helmet and burr cells.[ncbi.nlm.nih.gov] platelet count, and hemolytic anemia with schizocytes.[ncbi.nlm.nih.gov] This results in platelet activation endothelial cell damage, and white blood cell activation, leading to systemic TMA, which manifests as decreased platelet count, hemolysis[en.wikipedia.org]

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