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11 Possible Causes for Burr Cell, Fibrin Degradation Products Increased

  • Hemolytic Uremic Syndrome

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[wwwn.cdc.gov] No significant amounts of fibrin are formed and rather low amounts of fibrin degradation products are present.[ndt.oxfordjournals.org] Title Other Names: HUS; Acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells') Categories: Hemolytic[rarediseases.info.nih.gov]

  • Preeclampsia

    […] hemodilution of pregnancy Peripheral smear (schistocytes, burr cells, echinocytes) Increased bilirubin ( 1.2 mg/dL) Thrombocytopenia ( 100,000) due to hemolysis and low platelet[emedicine.com] Alternatively, values that are three standard deviations away from the mean for each laboratory value may be used for AST. [45] Histology The presence of schistocytes, burr[emedicine.com] Hematologic Studies A complete blood cell (CBC) count may reveal the following: Anemia due to microangiopathic hemolysis, hemoconcentration due to third spacing, or physiologic[emedicine.com]

  • Cerebral Thrombotic Thrombocytopenic Purpura

    cells, helmet-shaped RBCs, normoblasts, reticulocytosis, unconjugated BR, Hb, hemosiderin, haptoglobin, proteinuria Management Corticosteroids, aspirin, dipyridamole, Igs[medical-dictionary.thefreedictionary.com] […] hemolytic anemia Often severe with Hb 7-9g/dl; severity not related to other organ system dysfunction Negative Coombs' test Smear shows signs of microangiopahy: helmet & burr[faculty.washington.edu] A blood smear showed schistocytes, helmet cells, burr cells, and target cells consistent with a microangiopathic hemolytic anemia.[cdc.gov]

  • Microangiopathic Hemolytic Anemia

    - schistocytes, “burr cells”, “helmet cells” and “triangle cells”. 6.[slideshare.net] In addition, the levels of fibrinogen and fibrin degradation products are elevated, reflecting increased fibrinolytic activity.[medtextfree.wordpress.com] degradation products (FDP) from fibrinolysis interfere with platelet aggregation, potentiate bleeding risk Depletion of platelets, fibrinogen, and other hemostatic proteins[basicmedicalkey.com]

  • HELLP Syndrome

    Burr cells Schistocytes Reticulocyte count – consider to evaluate for presence of hemolysis Liver enzymes AST – 2 times the upper reference limit meets criteria LDH – markedly[arupconsult.com] The association between coagulation activation and pre-eclampsia has long been recognized and includes excessive platelet activation, increased fibrin degradation products[doi.org] Laboratory studies should include: Complete blood cell (CBC) count Coagulation studies Peripheral smear for schistocytes, helmet cells, burr cells Liver function tests: serum[symptoma.com]

  • Kasabach Merritt Syndrome

    The laboratory personnel should look for Burr cells and schistocytes.[symptoma.com] degradation products and D-dimers.[ncbi.nlm.nih.gov] Hemogram revealed anemia severe thrombocytopenia, prolongation of bleeding, clotting time and increased fibrin degradable products, suggestive of KMS.[e-ijd.org]

  • Cor Pulmonale

    A peripheral blood smear revealed burr cells and schistocytes, suggesting microangiopathic hemolytic anemia (MAHA).[kjim.org] Fibrin degradation product was elevated to 120 µg/mL (normal, 0 to 5), and the fibrinogen level was elevated to 623 mg/dL with a slightly increased PT of 16 seconds (international[kjim.org]

  • Acute Cor Pulmonale

    A peripheral blood smear revealed burr cells and schistocytes, suggesting microangiopathic hemolytic anemia (MAHA).[kjim.org] Serum D-dimer level D-dimer, a fibrin degradation product, should be used to exclude PE in patients with low or intermediate probability results.[ncbi.nlm.nih.gov] Fibrin degradation product was elevated to 120 µg/mL (normal, 0 to 5), and the fibrinogen level was elevated to 623 mg/dL with a slightly increased PT of 16 seconds (international[kjim.org]

  • Acquired Thrombotic Thrombocytopenic Purpura

    cells, helmet-shaped RBCs, normoblasts, reticulocytosis, unconjugated BR, Hb, hemosiderin, haptoglobin, proteinuria Management Corticosteroids, aspirin, dipyridamole, Igs[medical-dictionary.thefreedictionary.com] Prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen levels are usually normal in TTP with elevated levels of fibrin degradation products (FDP[clinicaladvisor.com] […] coagulation factors, complement proteins, Coombs-negative microangiopathic hemolytic anemia–often severe, 30% have Hb 55g/L, US: 5.5 g/dl and reticulocytosis, schistocytes, burr[medical-dictionary.thefreedictionary.com]

  • Familial X-Linked Thrombocytosis

    […] lines Often macrocytic Peripheral smear Bone marrow biopsy Bone marrow transplantation Epoetin, G-CSF Chronic Renal Disease Erythropoietin level Burr cells due to uremia[res.mednet.ucla.edu] […] levels of fibrin degradation products.[questdiagnostics.com] Nonimmune Hemolytic Anemia Last Updated on Wed, 09 Sep 2015 Bone Marrow The blood smear is characterized by the presence of burr erythrocytes, schistocytes, helmet cells,[78stepshealth.us]

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