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12 Possible Causes for Burr Cell, Fibrin Degradation Products Increased, Thrombotic Thrombocytopenic Purpura

  • Hemolytic Uremic Syndrome

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[wwwn.cdc.gov] No significant amounts of fibrin are formed and rather low amounts of fibrin degradation products are present.[ndt.oxfordjournals.org] Thrombotic thrombocytopenic purpura associated with ticlopidine-Thrombotic Thrombocytopenic Purpura (TTP) 271 a review of 60 cases. Ann Intern Med 1998;128: 541–544.[doi.org]

  • Cerebral Thrombotic Thrombocytopenic Purpura

    cells, helmet-shaped RBCs, normoblasts, reticulocytosis, unconjugated BR, Hb, hemosiderin, haptoglobin, proteinuria Management Corticosteroids, aspirin, dipyridamole, Igs[medical-dictionary.thefreedictionary.com] KEYWORDS: Cerebral microbleeds; MRI; ischemic stroke; thrombotic thrombocytopenic purpura[ncbi.nlm.nih.gov] […] hemolytic anemia Often severe with Hb 7-9g/dl; severity not related to other organ system dysfunction Negative Coombs' test Smear shows signs of microangiopahy: helmet & burr[faculty.washington.edu]

  • Microangiopathic Hemolytic Anemia

    - schistocytes, “burr cells”, “helmet cells” and “triangle cells”. 6.[slideshare.net] In addition, the levels of fibrinogen and fibrin degradation products are elevated, reflecting increased fibrinolytic activity.[medtextfree.wordpress.com] The similarity of the mother's illness to thrombotic thrombocytopenic purpura and of the daughter's to adult hemolytic uremic syndrome suggests that these diseases are variants[ncbi.nlm.nih.gov]

  • Preeclampsia

    […] hemodilution of pregnancy Peripheral smear (schistocytes, burr cells, echinocytes) Increased bilirubin ( 1.2 mg/dL) Thrombocytopenia ( 100,000) due to hemolysis and low platelet[emedicine.com] thrombocytopenic purpura and hemolytic uremic syndrome during her second pregnancy, before the correct diagnosis of atypical hemolytic uremic syndrome was recognized in the[ncbi.nlm.nih.gov] Alternatively, values that are three standard deviations away from the mean for each laboratory value may be used for AST. [45] Histology The presence of schistocytes, burr[emedicine.com]

  • HELLP Syndrome

    Burr cells Schistocytes Reticulocyte count – consider to evaluate for presence of hemolysis Liver enzymes AST – 2 times the upper reference limit meets criteria LDH – markedly[arupconsult.com] The association between coagulation activation and pre-eclampsia has long been recognized and includes excessive platelet activation, increased fibrin degradation products[doi.org] CONCLUSION: Thrombotic thrombocytopenic purpura can mimic HELLP syndrome late in gestation.[ncbi.nlm.nih.gov]

  • Acquired Thrombotic Thrombocytopenic Purpura

    cells, helmet-shaped RBCs, normoblasts, reticulocytosis, unconjugated BR, Hb, hemosiderin, haptoglobin, proteinuria Management Corticosteroids, aspirin, dipyridamole, Igs[medical-dictionary.thefreedictionary.com] BACKGROUND: Thrombotic thrombocytopenic purpura is a rare thrombotic microangiopathy, related to a severe ADAMTS13 deficiency (a disintegrin and metalloprotease with thromboSpondin[ncbi.nlm.nih.gov] Prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen levels are usually normal in TTP with elevated levels of fibrin degradation products (FDP[clinicaladvisor.com]

  • Kasabach Merritt Syndrome

    The laboratory personnel should look for Burr cells and schistocytes.[symptoma.com] A provisional diagnosis of thrombotic thrombocytopenic purpura was made and she was treated with steroids, plasma exchange, then intravenous immunoglobulin and rituximab,[pagepress.org] degradation products and D-dimers.[ncbi.nlm.nih.gov]

  • Acute Cor Pulmonale

    A peripheral blood smear revealed burr cells and schistocytes, suggesting microangiopathic hemolytic anemia (MAHA).[kjim.org] Thrombocytopenic Purpura Randomized Delayed-Start Trial of Levodopa in Parkinson’s Disease Challenge Yourself Interactive Medical Cases Image Challenge Videos in Clinical[nejm.org] Serum D-dimer level D-dimer, a fibrin degradation product, should be used to exclude PE in patients with low or intermediate probability results.[ncbi.nlm.nih.gov]

  • Cor Pulmonale

    A peripheral blood smear revealed burr cells and schistocytes, suggesting microangiopathic hemolytic anemia (MAHA).[kjim.org] He died 19 hours after admission due to cor pulmonale as a complication of metastatic desmoplastic small round cell tumor in the lungs with associated tumor thrombotic microangiopathy[ncbi.nlm.nih.gov] microangiopathy in two patients with breast cancer. ( 26842105 ) Moon SY...Yoon SY 2017 4 Acute cor pulmonale due to pulmonary tumour thrombotic microangiopathy from renal[malacards.org]

  • Renal Cell Carcinoma

    Ryan P Theis, Suzanne M Dolwick Grieb, Deborah Burr, Tariq Siddiqui and Nabih R Asal, Smoking, environmental tobacco smoke, and risk of renal cell cancer: a population-based[doi.org] We showed increase of the inflammatory reaction (white blood cell [WBC]: 11 500/µL, C-reactive protein [CRP]: 6.77 mg/mL) and hypercoagulable state (fibrin degradation product[journals.sagepub.com] Thrombotic microangiopathy (TMA) including thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS).[sutent.com]

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