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19 Possible Causes for Burr Cell, Fibrinogen Decreased, Thrombotic Thrombocytopenic Purpura

  • Hemolytic Uremic Syndrome

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[wwwn.cdc.gov] Thrombotic thrombocytopenic purpura associated with ticlopidine-Thrombotic Thrombocytopenic Purpura (TTP) 271 a review of 60 cases. Ann Intern Med 1998;128: 541–544.[doi.org] Title Other Names: HUS; Acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells') Categories: Hemolytic[rarediseases.info.nih.gov]

  • Cerebral Thrombotic Thrombocytopenic Purpura

    cells, helmet-shaped RBCs, normoblasts, reticulocytosis, unconjugated BR, Hb, hemosiderin, haptoglobin, proteinuria Management Corticosteroids, aspirin, dipyridamole, Igs[medical-dictionary.thefreedictionary.com] Characteristic laboratory findings include thrombocytopenia, decreased fibrinogen, increased prothrombin time, and abnormalities in tests for fibrinolysis.[ajnr.org] KEYWORDS: Cerebral microbleeds; MRI; ischemic stroke; thrombotic thrombocytopenic purpura[ncbi.nlm.nih.gov]

  • Microangiopathic Hemolytic Anemia

    - schistocytes, “burr cells”, “helmet cells” and “triangle cells”. 6.[slideshare.net] Fibrinogen is decreased and fibrin degradation products (such as D-dimer) are increased. Clinical findings may be indistinguishable from severe liver disease.[clinicaladvisor.com] The similarity of the mother's illness to thrombotic thrombocytopenic purpura and of the daughter's to adult hemolytic uremic syndrome suggests that these diseases are variants[ncbi.nlm.nih.gov]

  • HELLP Syndrome

    Burr cells Schistocytes Reticulocyte count – consider to evaluate for presence of hemolysis Liver enzymes AST – 2 times the upper reference limit meets criteria LDH – markedly[arupconsult.com] fibrinogen* Increased d-dimer level* Hemolysis-related results are as follows: Abnormal peripheral smear* Indirect bilirubin level over 1.2 mg/dL* LDH level greater than[emedicine.com] CONCLUSION: Thrombotic thrombocytopenic purpura can mimic HELLP syndrome late in gestation.[ncbi.nlm.nih.gov]

  • Anemia

    Burr cells accompany renal failure and spur cells accompany severe liver disease.[cancertherapyadvisor.com] Classic findings are elevated coagulation times, decreased platelets and fibrinogen, and the presence of fibrin split products.[emedicine.com] Hemolytic anemia This type of anemia includes sickle cell anemia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome, aortic valve prosthesis, disseminated[emedicine.com]

  • Uremic Pneumonitis

    Diagnosis Peripheral blood smear establishes the presence of MAHA by schistocytes, burr cells, helmet cells etc.[omicsonline.org] Marked prolongation of coagulation time, increased FDP and decreased serum fibrinogen titer help to distinguish between SpHUS and DIC.[chikd.org] Hematologic and associated serologic findings of HUS thrombotic microangiopathy (TMA) (and thrombotic thrombocytopenic purpura [TTP]) include the following: Anemia: Anemia[emedicine.medscape.com]

  • Uremic Anemia

    ., schistocytes, burr cells, or helmet cells) on peripheral blood smear, AND Renal injury (acute onset) evidenced by either hematuria, proteinuria, or elevated creatinine[wwwn.cdc.gov] […] develop and is believed to be a result of vWF or factor VIII storage depletion. 8,35-38 Cryoprecipitate: Cryoprecipitate is a blood product containing factor VIII, vWF, and fibrinogen[uspharmacist.com] Thrombotic thrombocytopenic purpura (similar to hemolytic-uremic syndrome ) involves nonimmunologic platelet destruction.[merckmanuals.com]

  • Atypical Hemolytic Uremic Syndrome

    A peripheral blood smear (PBS) was performed, which contained schistocytes (32%) with helmet and burr cells.[ncbi.nlm.nih.gov] Coagulation studies show normal or high activity of factor VIII, factor V, fibrinogen, fibrin monomers and fibrinogen degradation products.[biomed.uninet.edu] Thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS) are thrombotic microangiopathies (TMAs) that can present in pregnancy.[ncbi.nlm.nih.gov]

  • Cholestasis of Pregnancy

    It is characterized by microangiopathic hemolysis with burr cells and schistocytes on peripheral smear; elevated liver enzyme levels, with aspartate transaminase (AST) exceeding[clevelandclinicmeded.com] fibrinogen, renal failure, profound hypoglycemia and bilirubin levels of 1 to 10 mg per dL (17.1 to 171.0 μmol per L).[aafp.org] thrombocytopenic purpura.[jsth.org]

  • Kasabach Merritt Syndrome

    The laboratory personnel should look for Burr cells and schistocytes.[symptoma.com] Localized intravascular coagulation (LIC) was characterized by a decrease in fibrinogen (0.5-1 g/l), an increase in d-dimers (2-64 micro g/ml) and presence of soluble complex[ncbi.nlm.nih.gov] A provisional diagnosis of thrombotic thrombocytopenic purpura was made and she was treated with steroids, plasma exchange, then intravenous immunoglobulin and rituximab,[pagepress.org]

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